2004
DOI: 10.1182/blood-2004-01-0041
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Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment

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Cited by 284 publications
(274 citation statements)
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References 40 publications
(53 reference statements)
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“…Osteoclasts are associated with bone destruction in RA joints (6). Their origin in rheumatoid joints has not yet been identified, but findings of previous studies have indicated that bone marrow-derived CD14-positive cells are responsible for the development of osteoclasts and that both monocytes and dendritic cells can differentiate into functional osteoclasts (7)(8)(9)(10). Osteoclast formation requires cellcell interaction between osteoblasts and osteoclast precursors in bone remodeling.…”
mentioning
confidence: 99%
“…Osteoclasts are associated with bone destruction in RA joints (6). Their origin in rheumatoid joints has not yet been identified, but findings of previous studies have indicated that bone marrow-derived CD14-positive cells are responsible for the development of osteoclasts and that both monocytes and dendritic cells can differentiate into functional osteoclasts (7)(8)(9)(10). Osteoclast formation requires cellcell interaction between osteoblasts and osteoclast precursors in bone remodeling.…”
mentioning
confidence: 99%
“…In RA, the DCs are essential for initiation and perpetuation by Ag presentation as well as for cytokine and chemokine secretion (5,6). Furthermore, DCs are capable of transdifferentiating into osteoclasts, contributing directly to bone erosion (7,8). The maturation state of the DCs is crucial for determining the balance between tolerance and immunity.…”
mentioning
confidence: 99%
“…Important bone diseases, such as osteoporosis, rheumatoid arthritis, Paget's disease, and bone metastasis of breast and prostate cancers, are caused by increased osteoclast number and activity (1,2). Osteoclasts, the multinuclear cells, differentiate from hematopoietic precursors of the monocyte/macrophage lineage that also give rise to macrophages or dendritic cells (3,4).…”
mentioning
confidence: 99%