Imipramine-Induced Facial Pigmentation: Case Report and Literature Review

Metelitsa, Andrei I.; Nguyen, Gia‐Khanh; Lin, Andrew N.

doi:10.1007/s10227-005-0139-7

Cited by 12 publications

(11 citation statements)

References 8 publications

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“…, 2007); however, it remains a tertiary amine with high logP (7.1) that will be also subjected to ion trapping and may reproduce the side effects caused by tissue deposits of drugs. The present findings may also apply to other amine drugs that cause skin discoloration, like imipramine (logP 4.4, a tertiary amine), reported to cause a vacuolar cytopathology in dermal histiocytes (Metelitsa et al. , 2005).…”

Section: Discussionmentioning

confidence: 61%

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

Morissette

Ammoury

Rusu

et al. 2009

British J Pharmacology

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Background and purpose:Tissue deposits of the anti-arrhythmic drug amiodarone are a major source of side effects (skin discoloration, etc.). We addressed the mechanism of the concentration of amiodarone in cells, and characterized the resulting vacuolar cytopathology and its evolution towards macroautophagy. Experimental approach: Sequestration of amiodarone in human cells (macrophages, smooth muscle cells, HEK 293a cells) was evaluated using its violet fluorescence and cytopathology using GFP-conjugated subcellular markers. Autophagic signalling was probed by immunoblotting for the effector protein LC3. A patient biopsy of amiodarone-induced blue-gray skin discoloration was investigated for the presence of macroautophagy (immunofluorescence for LC3). Key results: Most of the amiodarone (1-20 mM, 4-24 h) captured by cultured cells (macrophages were most avid) was present in enlarged vacuoles. The specific vacuolar ATPase (V-ATPase) inhibitors, bafilomycin A1 or FR167356, prevented vacuolization and drug uptake. Vacuoles in HEK 293a cells were positive for markers of late endosomes and lysosomes (GFP-Rab7, -CD63) and for an effector of macroautophagy, GFP-LC3. The vacuoles accumulated endogenous LC3 and filled with lipids (Nile red staining) following longer amiodarone treatments (Ն24 h). The electrophoretic mobility of both GFP-LC3 and endogenous LC3 changed, showing activation in response to amiodarone. Paraffin tissue sections of the pigmented skin exhibited granular LC3 accumulation in superficial dermis macrophages. Conclusion and implications: Vacuolar sequestration of amiodarone occurs at concentrations close to therapeutic levels, is mediated by V-ATPase and evolves towards persistent macroautophagy and phospholipidosis. This cytopathology is not cell type specific, but tissue macrophages appear to be particularly susceptible.

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Section: Discussionmentioning

confidence: 61%

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

Morissette

Ammoury

Rusu

et al. 2009

British J Pharmacology

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“…The uptake of energy-based home-use devices for medical treatment and personal care is increasing rapidly, due to the appeal of their practicality, simplicity of use and reported efficacy (1). Within this trend, skin health attracts particular interest, underlined by the large burden of skin and hair diseases (2).…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Mignon

Botchkareva

Uzunbajakava

et al. 2016

Experimental Dermatology

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Photobiomodulation is reported to positively influence hair regrowth, wound healing, skin rejuvenation and psoriasis. Despite rapid translation of this science to commercial therapeutic solutions, significant gaps in our understanding of the underlying processes remain. The aim of this review was to seek greater clarity and rationality specifically for the selection of optical parameters for studies on hair regrowth and wound healing. Our investigation of 90 reports published between 1985 and 2015 revealed major inconsistencies in optical parameters selected for clinical applications. Moreover, poorly understood photoreceptors expressed in skin such as cytochrome c oxidase, cryptochromes, opsins etc. may trigger different molecular mechanisms. All this could explain the plethora of reported physiological effects of light. To derive parameters for optimal clinical efficacy of photobiomodulation, we recommend a more rational approach to underpin clinical studies, with research on molecular targets and pathways using well-defined biological model systems to enable translation of optical parameters from in vitro to in vivo. Furthermore, special attention needs to be paid when conducting studies for hair regrowth, aiming for double-blind, placebocontrolled randomized clinical trials as the gold standard for quantifying hair growth.

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“…It has been reported that tricyclic antidepressants could be photo-excited to activate tyrosinase, which in turn catalyzes melanin synthesis, leading to enhanced depositions of abnormal drug-melanin complex and reduced melanin clearance rates. 3 More recent studies also noted that serotonin agonist or fluoxetine treatment can induce melanogenesis. 4 These observations collectively might explain the cross-sensitivity of various SSRI with intrinsic activities to increase serotonin.…”

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confidence: 99%

Photosensitivity reaction associated with selective serotonin re‐uptake inhibitors: Possible cross‐sensitivity?

Cheng

Huang

2013

Psychiatry Clin Neurosci

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Imipramine-Induced Facial Pigmentation: Case Report and Literature Review

Abstract: Imipramine is a rare cause of gray-blue facial pigmentation. Light microscopy consistently shows granular dermal deposits that stain positively with Fontana-Masson stain but negatively with iron stain.

Cited by 12 publications

References 8 publications

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Photosensitivity reaction associated with selective serotonin re‐uptake inhibitors: Possible cross‐sensitivity?

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