Imine stilbene analog ameliorate isoproterenol-induced cardiac hypertrophy and hydrogen peroxide-induced apoptosis

Polyphenols’ Cardioprotective Potential: Review of Rat Fibroblasts as Well as Rat and Human Cardiomyocyte Cell Lines Research

“…The effect of different polyphenols on fibroblast cardiomyocytes, AC16 [17], myofibroblasts [23], H9c2 [10,11,13,18,19,24,25,27,28], neonatal rat cardiomyocytes [10,11], primary rat adult fibroblasts [23], rat cardiomyocytes [12,15,[20][21][22][23]26,30,31], as well as young and old human cardiomyocytes [29] was analyzed by different groups.…”

“…The cardioprotective activity of the imine stilbene analog was noticed by Raut et al (2020). This is possible since the analog protects cardiomyocytes against oxidative stress, suppresses autophagy and apoptosis, and indicates anti-hypertrophic activity [25].…”

“…Imine stilbene analog also prevents H 2 O 2 -induced ROS production, reduces expression of caspase 3 and LC3 as well as increases expression of Bcl-2 and AMPK. This suggests the protection of cardiomyocytes against oxidative stress as well as the suppression of autophagy and apoptosis [25].…”

“…Polyphenols have gained interest due to their cardioprotective effect, which is related to antioxidative activity [10][11][12][13][14][15], anti-inflammatory activity [11,[16][17][18], modulation and synchronization of cardiomyocyte beating [10], and protection against cell apopto- Polyphenols have gained interest due to their cardioprotective effect, which is related to antioxidative activity [10][11][12][13][14][15], anti-inflammatory activity [11,[16][17][18], modulation and synchronization of cardiomyocyte beating [10], and protection against cell apoptosis [11,13,14,[19][20][21][22][23][24][25], cardiac hypertrophy [11,21,25,26], and atherosclerosis ischemia/reperfusion injuries [4,[11][12][13]15,18].…”

Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2

“…Apoptosis is closely associated with in oxidative stress-induced cell damage. Besides the PI staining experiment as described in Figure 2E, the population of apoptotic PC12 cells was also determined using fluorescence microscopy after Hoechst 33342 staining [24,27] herein. As shown in Figure 3A, most cells in the control group were viable (I), whereas exposure to H 2 O 2 resulted in a significant increase in the number of apoptotic cells, as observed with blue fluorescence (IV).…”