Imidazolized magnetic nanovectors with endosome disrupting moieties for the intracellular delivery and imaging of siRNA

Kim, Eunjung; Lee, Hwunjae; An, Yonghee; Jang, Eunji; Lim, Eun‐Kyung; Kang, Byunghoon; Huh, Yong Min; Haam, Seungjoo

doi:10.1039/c4tb01274g

Cited by 10 publications

(5 citation statements)

References 41 publications

(51 reference statements)

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“…The synthesized nanovectors, complexed with siRNA, target the CD44 gene via electrostatic interactions to initiate a specific gene-silencing effect. 93 The PEI-PLL copolymer was synthesized via ring-opening polymerization of L-lysine N-carboxyanhydride initiated by PEI, which produces higher gene silencing efficiency and lower cytotoxicity than commercial PEI-25k in vitro. 94 The complexation of PEI-PLL with siVEGF (vascular endothelial growth factor) produced an observable tumor inhibition effect for the treatment of the CT26 tumor model, so it is a promising siRNA carrier candidate for further antitumor treatment.…”

Section: Poly-l-lysine (Pll)mentioning

confidence: 99%

Powering up the molecular therapy of RNA interference by novel nanoparticles

Liao

Li²,

Zhang

et al. 2016

Biomater. Sci.

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RNA interference technology has been widely applied in biomedical therapy in recent years. A type of small RNA molecule - siRNA could regulate the expression of disease related genes by breaking down the integrity of mRNA with high specificity. However, the low efficiency of siRNA delivery to its target seriously hampered the RNAi therapy. Compared with viral-based delivery systems, non-viral-based nanoparticles are more suitable for disease treatment due to reduced cellular toxicity, higher loading capacity, and better biocompatibility. This review article highlights several nanoparticle-based siRNA delivery systems, including liposomes, cationic solid lipid nanoparticles, reconstituted high density lipoprotein, polymeric nanoparticles, cationic cell penetrating peptides, and inorganic nanoparticles. The molecular mechanism of gene silencing, clinical examples, and the limitations of current technology related to nanomaterial sciences, are also discussed.

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Section: Poly-l-lysine (Pll)mentioning

confidence: 99%

Powering up the molecular therapy of RNA interference by novel nanoparticles

Liao

Li²,

Zhang

et al. 2016

Biomater. Sci.

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“…N 6‐Carbobenzyloxy‐ l ‐lysine N ‐carboxyanhydride (Lysine NCA) was synthesized by a previous reported method with minor changes . N 6‐carbobenzyloxy‐ l ‐lysine (5 g, 17.84 mmol) was suspended in 250 mL dry THF at 45 °C.…”

Section: Methodsmentioning

confidence: 99%

TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy

Zhuang

Liu

et al. 2017

J of Applied Polymer Sci

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Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6-carbobenzyloxy-L-lysine)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (TPE-PLys-b-PMPC) copolymer are successfully prepared. Such biomimetic and biodegradable TPE-PLys-b-PMPC micelles exhibit remarkable aggregation-induced emission (AIE) feature and great biocompatibility, showing great potential for bioimaging application. In addition, anticancer drug doxorubicin (DOX) can be incorporated into the core of micelles and the intracellular release of DOX can be furthermore traced through the fluorescent imaging of these AIE micelles. As expected, this DOX-loading polymeric micelle shows significant growth inhibition against HeLa cells and 4T1 cells and such TPE-PLys-b-PMPC micelles would be a promising drug carrier for potential cancer therapy and bioimaging. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018, 135, 45651.

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“…Theranostic nanoparticles comprise at least three components: (i) the biological payload, (ii) the carrier, and (iii) surface modifiers (Figure 1) [74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93]. Biological payloads include imaging agents and therapeutic agents.…”

Section: Optical Imaging In Drug Delivery (Theranostics)mentioning

confidence: 99%

Recent Advances in Bioimaging for Cancer Research

Lim¹,

Son²,

Lim³

2018

State of the Art in Nano-Bioimaging

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Molecular imaging techniques as well as nanoparticle applicable to molecular imaging are being explored to improve the cancer detection accuracy, which help to manage efficiently at the early stage. Among the various imaging technologies, optical imaging is a highly sensitive detection technique that allows direct observation of specific molecular events, biological pathways, and disease processes in real time through imaging probes that emit light in a range of wavelengths. Recently, nanoparticles have provided significant progresses that can be simultaneously used for cancer diagnosis and therapy (cancer theranostics). Theranostics aims to provide "image-guided cancer therapy," by integrating therapeutic and imaging agents in a single platform. In addition, molecular imaging techniques facilitate "image-guided surgery" enabling maximization of tumor excision and minimization of side effects. The optical signals generated by fluorescence nanoparticles offer the possibility to distinguish tumor sites and normal tissues during surgery by real-time guidance, thereby increasing the long-term patient survival. These techniques will considerably contribute to reducing cancer recurrence and developing more effective cures. In this chapter, we will introduce diverse research on nanomaterials-based optical imaging for effective cancer therapy.

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Imidazolized magnetic nanovectors with endosome disrupting moieties for the intracellular delivery and imaging of siRNA

Cited by 10 publications

References 41 publications

Powering up the molecular therapy of RNA interference by novel nanoparticles

Powering up the molecular therapy of RNA interference by novel nanoparticles

TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy

Recent Advances in Bioimaging for Cancer Research

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