Imidazolate-bridged dicopper(II) and copper(II)–zinc(II) complexes of macrocyclic ligand with methylimidazol pendants: Model study of copper(II)–zinc(II) superoxide dismutase

Electrophilic Modulation of the Superoxide Anion Radical Scavenging Ability of Copper(II) Complexes with 4-Methyl Imidazole

“…The activity of the metalloenzyme with O 2 •– ( k = 2.37 × 10 9 s –1 M –1 at 25 °C) is promoted by the redox reactivity of Cu­(II) and the acid–base behavior of the imidazole ligand. , Cu­(II) is reduced and oxidized by O 2 •– in a two-step mechanism: (i) Cu­(II) + O 2 •– →Cu­(I) + O 2 and (ii) Cu­(I) + O 2 •– + 2H + → Cu­(II) + H 2 O 2 . Many compounds with SOD and superoxide dismutation activities have been synthesized with different redox and non-redox pairs and heterocyclic ligands. − Our interest is to obtain active antioxidant coordination compounds that have minimal structural variation with the active site of CuZn-SOD and substituents that increase their water solubility. , To achieve our objective, we used inorganic salts of Cu­(II) and 4-methyl imidazole, which maintain the tetrahedral geometry of Cu­(II), similar to that found in the active site of the metalloenzyme. Our strategy to increase the antioxidant activity was to increase the ET process based on the principle that “as the electron transfer between O 2 •– (nucleophile) and the coordination compound (electrophile) increases, the interaction also increases”.…”

Synthesis and structure of coordination polymers of praseodymium(III) and erbium(III) with hydrogen maleate and benzene-1,3-disulfonate as linkers

“…Under the concept of reticular chemistry for the design of CPs and MOFs, various successful strategies have been developed for building such frameworks involving appropriate bridging linkers in various coordination modes [11][12][13][14][15][16][17][18][19]. Structural features of coordination polymers (CPs) are influenced by intrinsic features of ligands [20][21][22][23]. Hence, structural features and design of ligand play an essential role in this field.…”

Synthesis, Structure, and Properties of Dicopper Complex With Imidazole-Containing Polyamine Ligand

“…[1][2][3][4][5][6][7][8] In particular, the molecule/anion recognition has attracted increasing interest. [4][5][6][7][8] For example, we have reported several macrocyclic complexes, which could recognize and fix deprotonated imidazole molecule, and act as model compounds of Cu 2 Zn 2 -SOD. [7,8] In addtion, the linear azide anion is also extensively used in the self-assembly of complexes because of the various coordination modes and potential magnetic properties, etc.…”

“…[4][5][6][7][8] For example, we have reported several macrocyclic complexes, which could recognize and fix deprotonated imidazole molecule, and act as model compounds of Cu 2 Zn 2 -SOD. [7,8] In addtion, the linear azide anion is also extensively used in the self-assembly of complexes because of the various coordination modes and potential magnetic properties, etc. [9,10] So, as an extension of our work, we introduce the azide anion into the system, and report herein a new dicopper complex [Cu 2 (L)(N 3 ) 2 ](ClO 4 ) 2 ·4H 2 O (1), and the properties.…”