Imbalance between Lipid Peroxidation and Antioxidant Status in Preeclampsia

Abstract

Lipid peroxidation and the antioxidant system were investigated in the plasma and placenta of normal and preeclamptic pregnant women. A significant increase in thiobarbituric acid reactive substance (TBARS), significant decreases in total thiol (t-SH) content and superoxide dismutase (SOD) activity, and unchanged vitamin C levels and glutathione peroxidase (GPx) activity were observed in the plasma of preeclamptic women compared to women with normal pregnancies. In placentas from preeclamptic women TBARS levels were significantly elevated, while glutathione and vitamin C levels and GPx, glutathione S-transferase and SOD activities were decreased. After delivery, the elevated TBARS values decreased significantly and the reduced SOD activity and t-SH contents increased significantly. We concluded that preeclampsia is associated with an imbalance between lipid peroxides and the antioxidant system.

Lipid Peroxidation and Antioxidant Status in Preeclampsia

“…5,6,15,18 Some research workers reported that increased lipid peroxides in preeclampsia might be related to increased placental thromboxane formation which causes increased cyclooxygenase activity that would increase the free radical formation. 6,11,16,19 These findings are in agreement with the findings of other studies. 4,7,10.11 Several studies demonstrated that preeclampsia is associated with increased utilization of antioxidants.…”

“…These findings are in consistence with those of some other researchers. 3,4,7,16 They reported that lipid peroxidation increases during normal pregnancy. But lipid peroxides and free radicals productions are more in preeclampsia than normal pregnancies and may be the important factors in pathogenesis of preeclampsia.…”

Differential effects of docosahexaenoic acid on preterm and term placental pro-oxidant/antioxidant balance

“…The placenta is an important source of products of oxidative stress, such as lipid peroxides (Mutlu-Turkoglu et al 1998). Theoretical concerns exist that dietary n-3 fatty acid supplementation may lead to increased placental oxidative stress (Shoji et al 2009).…”

Estimation of Lipid Profile in Subjects of Preeclampsia

“…Preeclampsia occurs in 7-10% of pregnancies world wide [2]. In India, the national incidence is reported to be 8-10% of pregnancies.…”