Estimation of Lipid Profile in Subjects of Preeclampsia

Gohil, J. T.; Patel, Pooja; Gupta, Priyanka

doi:10.1007/s13224-011-0057-0

Cited by 58 publications

(55 citation statements)

References 5 publications

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“…Twenty‐seven studies reported on HDL levels,32, 37, 41, 44, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 of which 24 studies could be included in a meta‐analysis 32, 37, 41, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72. HDL level was lower in pre‐eclampsia than in controls (mean difference −6.29 mmol/L; 95%CI −9.74−2.85; P = 0.0003) with the strongest effect in subgroup analysis for severe pre‐eclampsia vs. controls ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…2,3 In non interventioned, pre-eclamptic cases may progress further to the dreaded complications like; eclampsia, HELLP syndrome, pulmonary edema, abruption placentae, postpartum circulatory collapse, acute renal failure, hepatic rupture, cerebral haemorrhage and visual disturbances including death. These conditions are also a major cause of neonatal morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

A case control study on s. uric acid and s. creatinine level in pre-eclampsia patients of a tertiary care hospital in Jabalpur district of Central India

et al. 2018

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Background: Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Serum creatinine and uric acid has been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. This study compares the serum creatinine and uric acid in pre -eclampsia case and normal pregnant women and to assess its role in pre-eclampsia.Methods: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of Obstretics and Gynecology in March 2016 to August 2017. Lipid profile was estimated by the Randox imola is a compact fully automated clinical chemistry analyser.Results: Authors observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean serum creatinine and urice acid value is analysed in pre-eclampia cases and compared with control group showing significantly increase (p<0.0001).Conclusions: Young age, nullyparity, low socio economic status specially labour occupation, with derangment of Serum creatinine in pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of serum creatinine and uric acid may be helpful for early diagnosis and management of pre–eclampsia in order to prevent fetal and maternal complications especially in nulliparous women.

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“…While some previous studies have shown significant decrease in HDL level among hypertensive patients. 3,9,12,13 In present study maternal dyslipidemia occurs with preeclampsia and eclampsia. There is accentuation of the normal pregnancy changes.…”

Section: Discussionmentioning

confidence: 56%

Feto-maternal impact of altered lipid profile in pregnancy

Singh¹,

Kujur²,

Jain³

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONHypertensive disorders complicate approximately 10% of all pregnancies worldwide, with onset of symptoms in the late second or third trimester, most commonly after the 32nd week.1 The national incidence is reported to be 8-10%.2 Preeclampsia is one of the major cause of maternal mortality in developed and developing countries. It is also a leading cause of perinatal morbidity and mortality and it is very strongly related to fetal growth retardation. To avoid complications, it is very important to diagnose it early, but the available tools are unable to clinch the diagnosis of preeclampsia effective in majority. Pregnancy-induced hypertension(PIH) is one of the major risk factors in present day health care practice because it not only causes maternal mortality but also impaires fetal development during pregnancy. Pre-eclampsia is a multi-system disorder of pregnancy, which is characterised by new onset hypertension and proteinuria that develop after 20 weeks of gestation in previously normotensive women. Pregnancy-induced hypertension(PIH) is one of the major risk factors in present day health care practice because it not only causes Results:Out of 200 antenatal women recruited in our study, 129 had normal lipid profile throughout pregnancy and 71 women developed dyslipidemia.89 % of those women having normal lipid profile did not develop any maternal or perinatal complication, showing a high negative predictive value (88.72%) and high specificity of 91.47%. We observed that the onset of dyslipidemia occurred in 2nd trimester and it was progressive. About 83.58 % of them developed toxemia of pregnancy (GHTN, preeclampsia, eclampsia), positive predictive value of 83.58%. The levels of TC (total cholesterol), TG(triglyceride), VLDL (very low-density lipoprotein) and LDL (low density lipoprotein) were significantly (p<0.0001) higher in hypertensive women than normotensive women. Dyslipidemic women have developed significant (p= 0.00001) level of perinatal complications like preterm (18.05%), IUGR (15.28%) and IUD (13.89%). Sensitivity-78.9, Specificity-88.72, Positive likelihood ratio-9.25, Negative likelihood ratio-0.23. Conclusions: Early pregnancy dyslipidemia was significantly associated with an increased risk of preeclampsia and eclampsia. Thus, evaluating dyslipidemia in 1 st and 2 nd trimester may help in early prediction and management of maternal as well as fetal complication.

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Estimation of Lipid Profile in Subjects of Preeclampsia

Cited by 58 publications

References 5 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

A case control study on s. uric acid and s. creatinine level in pre-eclampsia patients of a tertiary care hospital in Jabalpur district of Central India

Feto-maternal impact of altered lipid profile in pregnancy

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