Imaging the Sleep Deprived Brain: A Brief Review

Chee, Michael W.L.

doi:10.13078/jksrs.13001

Cited by 4 publications

(5 citation statements)

References 69 publications

(96 reference statements)

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“…Our findings seems to be consistent with extensive literature supporting the role of sleep in modulating insular activity (Flynn, ) particularly when involved in regulatory behavior. In fact, a variety of neuroimaging studies have described the neural mechanisms that characterize a sleep‐deprived brain (Chee, ). Particularly, several fMRI studies have shown how sleep deprivation, or inadequate sleep, may cause a specific alteration in the neural activity of the insula (Chee et al., ; Chuah, Venkatraman, Dinges, & Chee, ; Tomasi et al., ; Venkatraman, Huettel, Chuah, Payne, & Chee, ).…”

Section: Discussionmentioning

confidence: 99%

Sleep quality and its association with the insular cortex in emotional empathy

Guadagni

Burles

Ferrara

et al. 2018

Eur J of Neuroscience

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The human ability to vicariously share someone else's emotions (i.e., emotional empathy) relies on an extended neural network including regions in the anterior cingulate and insular cortex. Here, we tested the hypothesis that good sleep quality is associated with increased activation in the brain areas underlying emotional empathy. To this aim, we assessed subjective sleep quality in a large sample of healthy young volunteers, and asked participants to complete a computerized emotional empathy task. Then, we asked 16 participants to complete the same task while undergoing functional Magnetic Resonance Imaging (fMRI). After confirming the behavioral relationship between quality of sleep and emotional empathy in the large sample, we conducted a Region of Interest (ROI) analysis on selected ROIs involved in emotional empathy, and measured Blood Oxygen Level Dependent (BOLD) signal change in participants who performed the emotional empathy task in the MRI scanner; additionally, we assessed how the BOLD signal in different brain areas temporally correlated with performance throughout the task (i.e., task-based functional connectivity). We found increased BOLD signal change in a selective region within the left insula for individuals with better subjective sleep quality. These findings provide the very first evidence that individuals' sleep quality relates to emotional empathic responses through increased neural activation of a specific area within the insular cortex.

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Section: Discussionmentioning

confidence: 99%

Sleep quality and its association with the insular cortex in emotional empathy

Guadagni

Burles

Ferrara

et al. 2018

Eur J of Neuroscience

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“…Future neuroimaging studies may test the hypothesis that reduced empathic responses (as an effect of sleep deprivation) may be related to functional and structural properties of selective neural mechanisms responsible for empathy. In fact, sleep deprivation has been shown to affect the resting state functional connectivity between a variety of brain areas including the thalamus, posterior cingulate cortex, anterior cingulate cortex, ventromedial prefrontal cortex and amygdala (Chee, ). In addition to changes in resting state connectivity, sleep loss has also been shown to alter task‐related neural activity in the IFG (Habeck et al ., ).…”

Section: Discussionmentioning

confidence: 99%

The effects of sleep deprivation on emotional empathy

Guadagni

Burles

Ferrara

et al. 2014

Journal of Sleep Research

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Summary Previous studies have shown that sleep loss has a detrimental effect on the ability of the individuals to process emotional information. In this study, we tested the hypothesis that this negative effect extends to the ability of experiencing emotions while observing other individuals, i.e. emotional empathy. To test this hypothesis, we assessed emotional empathy in 37 healthy volunteers who were assigned randomly to one of three experimental groups: one group was tested before and after a night of total sleep deprivation (sleep deprivation group), a second group was tested before and after a usual night of sleep spent at home (sleep group) and the third group was tested twice during the same day (day group). Emotional empathy was assessed by using two parallel versions of a computerized test measuring direct (i.e. explicit evaluation of empathic concern) and indirect (i.e. the observer's reported physiological arousal) emotional empathy. The results revealed that the post measurements of both direct and indirect emotional empathy of participants in the sleep deprivation group were significantly lower than those of the sleep and day groups; post measurement scores of participants in the day and sleep groups did not differ significantly for either direct or indirect emotional empathy. These data are consistent with previous studies showing the negative effect of sleep deprivation on the processing of emotional information, and extend these effects to emotional empathy. The findings reported in our study are relevant to healthy individuals with poor sleep habits, as well as clinical populations suffering from sleep disturbances.

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“…Positron emission tomography studies have shown enhanced activity in the limbic system, which is associated with emotion, following SD ( 13 ). In addition, several studies have indicated that an increased emotional state after SD is correlated with the emotional control of brain functioning ( 10 , 14 ). Together, these studies confirm that SD induces a decline in emotional state and emotional instability as SD is prolonged.…”

Section: Introductionmentioning

confidence: 99%

Decreased Functional Connectivity in the Reward Network and Its Relationship With Negative Emotional Experience After Total Sleep Deprivation

et al. 2021

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Sleep deprivation (SD) induces a negative emotional experience due to a prolonged time spent awake. However, few studies have focused on the mechanism underlying communication within brain networks or alterations during this emotional deterioration. We propose that negative reward judgment is important in poor emotional processing after SD, which will be reflected in functional connectivity in the reward network. We sought to analyze alterations in functional connectivity within the reward network and cerebral cortex. Furthermore, we analyzed changes in functional connectivity correlation with negative emotional experience after SD. Twenty-six healthy volunteers participated in this study. Two resting-state fMRI scans were obtained from the participants, once during resting wakefulness, and once after 36 h of total SD. The bilateral nucleus accumbens (NAc) was selected as a seed region for region of interest (ROI)-to-ROI functional connectivity analysis. Correlation analyses between functional connectivity alterations within the reward network and negative emotional experience were also performed. We found that SD decreased functional connectivity between the left NAc and anterior cingulate cortex (ACC) compared with resting wakefulness. There was a decreased functional connectivity with the ACC and right inferior frontal gyrus (IFG) after SD in the right NAc. Furthermore, decreased functional connectivity between the right NAc and right IFG, and NAc and ACC was negatively correlated with emotional experience scores. Sleep deprivation decreased functional connectivity within the reward network. This may be associated with the enhanced negative emotional experience that was found after total sleep deprivation.

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Imaging the Sleep Deprived Brain: A Brief Review

Cited by 4 publications

References 69 publications

Sleep quality and its association with the insular cortex in emotional empathy

Sleep quality and its association with the insular cortex in emotional empathy

The effects of sleep deprivation on emotional empathy

Decreased Functional Connectivity in the Reward Network and Its Relationship With Negative Emotional Experience After Total Sleep Deprivation

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