ObjectiveTo test the hypothesis that aerobic exercise is associated with improvements in cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged and older adults (mean ± SD age 65.9 ± 6.4 years) in a supervised 6-month aerobic exercise intervention and assessed them before and after the intervention.MethodsThe study is a quasi-experimental single group pre/postintervention study. Neuropsychological tests were used to assess cognition before and after the intervention. Transcranial Doppler ultrasound was used to measure cerebral blood flow velocity. Cerebrovascular regulation was assessed at rest, during euoxic hypercapnia, and in response to submaximal exercise. Multiple linear regression was used to examine the association between changes in cognition and changes in cerebrovascular function.ResultsThe intervention was associated with improvements in some cognitive domains, cardiorespiratory fitness, and cerebrovascular regulation. Changes in executive functions were negatively associated with changes in cerebrovascular resistance index (CVRi) during submaximal exercise (β = −0.205, p = 0.013), while fluency improvements were positively associated with changes in CVRi during hypercapnia (β = 0.106, p = 0.03).ConclusionThe 6-month aerobic exercise intervention was associated with improvements in some cognitive domains and cerebrovascular regulation. Secondary analyses showed a novel association between changes in cognition and changes in cerebrovascular regulation during euoxic hypercapnia and in response to submaximal exercise.

Summary Previous studies have shown that sleep loss has a detrimental effect on the ability of the individuals to process emotional information. In this study, we tested the hypothesis that this negative effect extends to the ability of experiencing emotions while observing other individuals, i.e. emotional empathy. To test this hypothesis, we assessed emotional empathy in 37 healthy volunteers who were assigned randomly to one of three experimental groups: one group was tested before and after a night of total sleep deprivation (sleep deprivation group), a second group was tested before and after a usual night of sleep spent at home (sleep group) and the third group was tested twice during the same day (day group). Emotional empathy was assessed by using two parallel versions of a computerized test measuring direct (i.e. explicit evaluation of empathic concern) and indirect (i.e. the observer's reported physiological arousal) emotional empathy. The results revealed that the post measurements of both direct and indirect emotional empathy of participants in the sleep deprivation group were significantly lower than those of the sleep and day groups; post measurement scores of participants in the day and sleep groups did not differ significantly for either direct or indirect emotional empathy. These data are consistent with previous studies showing the negative effect of sleep deprivation on the processing of emotional information, and extend these effects to emotional empathy. The findings reported in our study are relevant to healthy individuals with poor sleep habits, as well as clinical populations suffering from sleep disturbances.

Objective: To investigate the sex and gender differences in the impact of the isolation period implemented in response to the COVID-19 pandemic on individuals' sleep quality, empathy, and mood. Design: Data were collected between March 23 and June 7, 2020 on a sample of volunteers in the Canadian population. Six hundred and thirty-eight volunteers completed an online survey (∼30 min). Main Outcome and Measures: We first examined biological sex, gender, and sexual identity differences (both components of the ampler concept of gender) in sleep, empathy, and mood disturbances. Then, we assessed changes in sleep and mood over the course of the isolation period and tested for significant relationships between sleep variables, mood, and empathy. Results: We analyzed complete data for 573 participants (112 males and 459 females, 2 undisclosed, mean ± SD age = 25.9 ± 10.5 years, mean ± SD education = 16.2 ± 2.9 years). As compared to males, female participants reported lower quality of sleep, lower sleep efficiency, and greater symptoms of insomnia, anxiety, depression, and trauma. In addition, females reported higher scores than males on the IRI empathy scale and all its subcomponents. Similar results were found when stratifying by gender. Sleep and mood disturbances increased over the course of the isolation period in the whole sample. The most significant predictors of poor quality of sleep and insomnia were depression, anxiety, and trauma scores, especially in females; higher empathy trait was associated with higher depression, anxiety, and trauma scores, perhaps indicating a more positive role of fear and anxiety responses to the pandemic crisis. Significance and Conclusions: Sex and gender differences seem to play a role in the individuals' psychological and behavioral reactions to the COVID-19 pandemic. These differences need to be considered in planning targeted psychological interventions.

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Objective: Neurocognitive functions are affected by high altitude, however the altitude effects of acclimatization and repeated exposures are unclear. We investigated the effects of acute, subacute and repeated exposure to 5,050 m on cognition among altitude-naïve participants compared to control subjects tested at low altitude.Methods: Twenty-one altitude-naïve individuals (25.3 ± 3.8 years, 13 females) were exposed to 5,050 m for 1 week (Cycle 1) and re-exposed after a week of rest at sea-level (Cycle 2). Baseline (BL, 520 m), acute (Day 1, HA1) and acclimatization (Day 6, HA6, 5,050 m) measurements were taken in both cycles. Seventeen control subjects (24.9 ± 2.6 years, 12 females) were tested over a similar period in Calgary, Canada (1,103 m). The Reaction Time (RTI), Attention Switching Task (AST), Rapid Visual Processing (RVP) and One Touch Stockings of Cambridge (OTS) tasks were administered and outcomes were expressed in milliseconds/frequencies. Lake Louise Score (LLS) and blood oxygen saturation (SpO2) were recorded.Results: In both cycles, no significant changes were found with acute exposure on the AST total score, mean latency and SD. Significant changes were found upon acclimatization solely in the altitude group, with improved AST Mean Latency [HA1 (588 ± 92) vs. HA6 (526 ± 91), p < 0.001] and Latency SD [HA1 (189 ± 86) vs. HA6 (135 ± 65), p < 0.001] compared to acute exposure, in Cycle 1. No significant differences were present in the control group. When entering Acute SpO2 (HA1-BL), Acclimatization SpO2 (HA6-BL) and LLS score as covariates for both cycles, the effects of acclimatization on AST outcomes disappeared indicating that the changes were partially explained by SpO2 and LLS. The changes in AST Mean Latency [ΔBL (−61.2 ± 70.2) vs. ΔHA6 (−28.0 ± 58), p = 0.005] and the changes in Latency SD [ΔBL (−28.4 ± 41.2) vs. ΔHA6 (−0.2235 ± 34.8), p = 0.007] across the two cycles were smaller with acclimatization. However, the percent changes did not differ between cycles. These results indicate independent effects of altitude across repeated exposures.Conclusions: Selective and sustained attention are impaired at altitude and improves with acclimatization.The observed changes are associated, in part, with AMS score and SpO2. The gains in cognition with acclimatization during a first exposure are not carried over to repeated exposures.

Abstract. Sleep loss is known to severely disturb individuals’ mood and emotion processing. Here, we tested the hypothesis that quality of sleep is predictive of individuals’ performance on a task evaluating emotional empathy. We tested 34 healthy undergraduate students [19 males, mean (SD) age = 21.82 (3.26) years; mean (SD) education = 14.98 (1.91) years] recruited through the University of Calgary research participation system. We collected objective (actigraphy) and subjective (questionnaires and self-reports) sleep measures to characterize individuals’ sleep quality, and asked participants to solve a computerized emotional empathy task. We first performed a dimensionality reduction analysis on the sleep-related measures, which resulted in six principal components, and then ran a stepwise multiple regression analysis to investigate the sleep measures that best predicted participants’ scores on the emotional empathy task. We found that subjective sleep quality, together with sleep phase, best predicted participants’ empathic sensitivity to negative images while they explicitly evaluated the emotions of others (i.e., direct component of emotional empathy). Also, subjective sleep quality resulted to be the best predictor of participants’ arousal state in response to negative images, which is an implicit manifestation of their empathic experience (i.e., indirect component of emotional empathy). In both cases, lower subjective sleep quality was associated with lower empathic sensitivity to negative stimuli. Finally, sleep duration best predicted average empathic responses to stimuli of all valences, with shorter sleep durations associated with lower average empathic responses. Our findings provide evidence of a significant relationship between individuals’ quality of sleep and their ability to share the emotions experienced by others. These findings may have important implications for individuals employed in professions requiring social interaction and empathic experience coupled with schedules that interfere with nighttime sleep.

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