Imaging technique for real-time temperature monitoring during cryotherapy of lesions

Петрова, Е. В.; Liopo, Anton V.; Nadvoretskiy, Vyacheslav; Ermilov, Sergey A.

doi:10.1117/1.jbo.21.11.116007

Cited by 13 publications

(27 citation statements)

References 51 publications

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“…Several studies have reported on the nonlinear temperature dependence of the Grüneisen parameter when the temperature exceeds the linear range. [57][58][59] In our method, the temperature is recovered from the estimated Grüneisen parameter only at the last step of the process, so a nonlinear temperature dependence may also work in our model. Computational time cost is also an important performance index of the method, especially for applications that need fast temperature mapping.…”

Section: Discussionmentioning

confidence: 99%

Deep-tissue temperature mapping by multi-illumination photoacoustic tomography aided by a diffusion optical model: a numerical study

et al. 2018

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Temperature mapping during thermotherapy can help precisely control the heating process, both temporally and spatially, to efficiently kill the tumor cells and prevent the healthy tissues from heating damage. Photoacoustic tomography (PAT) has been used for noninvasive temperature mapping with high sensitivity, based on the linear correlation between the tissue's Grüneisen parameter and temperature. However, limited by the tissue's unknown optical properties and thus the optical fluence at depths beyond the optical diffusion limit, the reported PAT thermometry usually takes a ratiometric measurement at different temperatures and thus cannot provide absolute measurements. Moreover, ratiometric measurement over time at different temperatures has to assume that the tissue's optical properties do not change with temperatures, which is usually not valid due to the temperature-induced hemodynamic changes. We propose an optical-diffusion-model-enhanced PAT temperature mapping that can obtain the absolute temperature distribution in deep tissue, without the need of multiple measurements at different temperatures. Based on the initial acoustic pressure reconstructed from multi-illumination photoacoustic signals, both the local optical fluence and the optical parameters including absorption and scattering coefficients are first estimated by the optical-diffusion model, then the temperature distribution is obtained from the reconstructed Grüneisen parameters. We have developed a mathematic model for the multi-illumination PAT of absolute temperatures, and our two-dimensional numerical simulations have shown the feasibility of this new method. The proposed absolute temperature mapping method may set the technical foundation for better temperature control in deep tissue in thermotherapy.

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Section: Discussionmentioning

confidence: 99%

Deep-tissue temperature mapping by multi-illumination photoacoustic tomography aided by a diffusion optical model: a numerical study

et al. 2018

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“…The monitored tissues are well vascularized. Therefore, for temperature imaging, we employed the previously developed method utilizing a reference OA frame at the known temperature just prior to initiation of cryotherapy (Petrova et al , 2016). The temperature imaging procedure included two steps: (1) obtain the OA reference frame including the region of interest (ROI) at a known temperature prior to cryotherapy, (2) normalize subsequent OA frames to the reference frame and use the calibration equation for the optoacoustic temperature imaging (OA-Tim) obtained for blood to convert each normalized frame to the temperature map.…”

Section: Methodsmentioning

confidence: 99%

“…The temperature imaging procedure included two steps: (1) obtain the OA reference frame including the region of interest (ROI) at a known temperature prior to cryotherapy, (2) normalize subsequent OA frames to the reference frame and use the calibration equation for the optoacoustic temperature imaging (OA-Tim) obtained for blood to convert each normalized frame to the temperature map. The method showed in vitro accuracy as high as ±1°C for temperatures below 0°C and average accuracy of ±3°C for the entire interrogated range of temperatures between 40°C and −16°C (Petrova et al , 2016).…”

Section: Methodsmentioning

confidence: 99%

“…An ideal image-guiding component of the cryotherapy system should provide real-time visualization of the temperature changes in the treated tissue, be compatible with the used therapeutic equipment, convenient in operation, and should not drive the cost of the entire instrument prohibiting its clinical use. Optoacoustic tomography (OAT) was previously proposed for real-time temperature imaging of live vascularized tissue (Petrova et al , 2014; Petrova et al , 2016). OAT is a method that combines pulsed optical excitation of live tissue and ultrasound detection of the generated pressure waves to overcome resolution limits imposed by light scattering (Wang and Hu, 2012; Oraevsky, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the proposed temperature imaging technique should be applicable for thermal interrogation of both microvasculature and systemic blood vessels carrying venal or arterial blood. We also established a procedure providing accurate conversion of optoacoustic images of vascularized tissues to the temperature maps (Petrova et al , 2016). The procedure was validated in tissue-mimicking phantoms for the clinically relevant range of temperatures, spatial temperature gradients, and time-frames typical for cryotherapy.…”

Section: Introductionmentioning

confidence: 99%

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In vivooptoacoustic temperature imaging for image-guided cryotherapy of prostate cancer

et al. 2018

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The objective of this study is to demonstrate in vivo the feasibility of optoacoustic temperature imaging during cryotherapy of prostate cancer. We developed a preclinical prototype optoacoustic temperature imager that included pulsed optical excitation at a wavelength of 805 nm, a modified clinical transrectal ultrasound probe, a parallel data acquisition system, image processing and visualization software. Cryotherapy of a canine prostate was performed in vivo using a commercial clinical system, Cryocare CS, with an integrated ultrasound imaging. The universal temperature-dependent optoacoustic response of blood was employed to convert reconstructed optoacoustic images to temperature maps. Optoacoustic imaging of temperature during prostate cryotherapy was performed in the longitudinal view over a region of 30 mm (long) × 10 mm (deep) that covered the rectum, the Denonvilliers fascia, and the posterior portion of the treated gland. The transrectal optoacoustic images showed high-contrast vascularized regions, which were used for quantitative estimation of local temperature profiles. The constructed temperature maps and their temporal dynamics were consistent with the arrangement of the cryoprobe and readouts of the thermal needle sensors. The temporal profiles of the readouts from the thermal needle sensors and the temporal profile estimated from the normalized optoacoustic intensity of the selected vascularized region showed significant resemblance, except for the initial overshoot, that may be explained as a result of the physiological thermoregulatory compensation. The temperature was mapped with errors not exceeding ±2 °C (standard deviation) consistent with the clinical requirements for monitoring cryotherapy of the prostate. In vivo results showed that the optoacoustic temperature imaging is a promising non-invasive technique for real-time imaging of tissue temperature during cryotherapy of prostate cancer, which can be combined with transrectal ultrasound-the current standard for guiding clinical cryotherapy procedure.

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Temperature-dependent optoacoustic response and transient through zero Grüneisen parameter in optically contrasted media

et al. 2017

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Non-invasive optoacoustic mapping of temperature in tissues with low blood content can be enabled by administering external contrast agents. Some important clinical applications of such approach include temperature mapping during thermal therapies in a prostate or a mammary gland. However, the technique would require a calibration that establishes functional relationship between the measured normalized optoacoustic response and local tissue temperature. In this work, we investigate how a key calibration parameter – the temperature of zero optoacoustic response (T0) – behaves in different environments simulating biological tissues augmented with either dissolved or particulate (nanoparticles) contrast agents. The observed behavior of T0 in ionic and molecular solutions suggests that in-vivo temperature mapping is feasible for contrast agents of this type, but requires knowledge of local concentrations. Oppositely, particulate contrast agents (plasmonic or carbon nanoparticles) demonstrated concentration-independent thermal behavior of optoacoustic response with T0 defined by the thermoelastic properties of the local environment.

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Imaging technique for real-time temperature monitoring during cryotherapy of lesions

Cited by 13 publications

References 51 publications

Deep-tissue temperature mapping by multi-illumination photoacoustic tomography aided by a diffusion optical model: a numerical study

Deep-tissue temperature mapping by multi-illumination photoacoustic tomography aided by a diffusion optical model: a numerical study

In vivooptoacoustic temperature imaging for image-guided cryotherapy of prostate cancer

Temperature-dependent optoacoustic response and transient through zero Grüneisen parameter in optically contrasted media

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