Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans

Hesse, Swen; Brust, Peter; Mäding, P.; Becker, Georg-Alexander; Patt, Marianne; Seese, Anita; Sorger, Dietlind; Zessin, J.; Meyer, Philipp; Lobsien, Donald; Laudi, Sven; Habermann, Bernd; Füchtner, F.; Luthardt, Julia; Bresch, Anke; Steinbach, Jörg; Sabri, Osama

doi:10.1007/s00259-012-2078-z

Cited by 29 publications

(13 citation statements)

References 22 publications

(37 reference statements)

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“…However, (S)-18 F-fluspidine is significantly more stable (52% metabolized at 16 min after injection), suggesting stereospecific metabolism as previously shown for other drugs (21). Furthermore, metabolism in humans may differ from animals, as reflected by a considerably lower metabolism of (1)-18 F-FMe-McN5652 in humans in comparison to pigs (22).…”

Section: Discussionmentioning

confidence: 70%

Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

et al. 2014

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Section: Discussionmentioning

confidence: 70%

Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

et al. 2014

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“…PET and MRI data processing were performed as recently described [14]. In short, individual MRI data sets of the subjects were spatially reoriented (according to the anterior commissure–posterior commissure line) onto a standard brain data set similar to the Talairach space using the image processing software PMOD version 3.3 (PMOD Technologies, Zurich, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Central noradrenaline transporter availability in highly obese, non-depressed individuals

Hesse

Becker

Rullmann

et al. 2017

Eur J Nucl Med Mol Imaging

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Purpose The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. Methods We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S, S-[11C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m2), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m2) healthy controls. Results Overall, we found no significant differences in binding potential (BPND) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BPND in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BPND patterns between both groups but this did not survive testing for multiple comparions. Conclusions Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation.

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“…PET and MRI data processing have been previously described . In short, individual MR data sets were spatially reoriented onto a standard brain data set similar to the Talairach space using the image processing software PMOD version 3.4 (PMOD Technologies Ltd., Zurich, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Emotional eating and in vivo norepinephrine transporter availability in obesity: A [¹¹C]MRB PET pilot study

Bresch

Rullmann

Luthardt

et al. 2016

Intl J Eating Disorders

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Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans

Abstract: The results showed that (+)-[(18)F]FMe-McN5652 is also suitable for in vivo quantification of SERT with PET. Because of the long half-life of (18)F, the widespread use within a satellite concept seems feasible.

Cited by 29 publications

References 22 publications

Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

Central noradrenaline transporter availability in highly obese, non-depressed individuals

Emotional eating and in vivo norepinephrine transporter availability in obesity: A [¹¹C]MRB PET pilot study

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Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans

Abstract: The results showed that (+)-[(18)F]FMe-McN5652 is also suitable for in vivo quantification of SERT with PET. Because of the long half-life of (18)F, the widespread use within a satellite concept seems feasible.

Cited by 29 publications

References 22 publications

Distinctive In Vivo Kinetics of the New σ1 Receptor Ligands (R)-(+)- and (S)-(–)-18F-Fluspidine in Porcine Brain

Distinctive In Vivo Kinetics of the New σ1 Receptor Ligands (R)-(+)- and (S)-(–)-18F-Fluspidine in Porcine Brain

Central noradrenaline transporter availability in highly obese, non-depressed individuals

Emotional eating and in vivo norepinephrine transporter availability in obesity: A [11C]MRB PET pilot study

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Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

Emotional eating and in vivo norepinephrine transporter availability in obesity: A [¹¹C]MRB PET pilot study