Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography

Abstract

MAs can develop during the course of RVO and DR. ICGA and HR-OCT improves the identification of capillary and venous MAs, and may thus be of interest to better identify sites of blood-retinal barrier rupture during chronic macular edema due to RVO or DR.

Subretinal Hyperreflective Exudation Associated With Neovascular Age-Related Macular Degeneration

“…Right eye of a 75-year-old woman with NVAMD associated with Type 1 neovascularization. 12 Interestingly, patients with Type 3 CNV had increased fluorescence on ICGA when compared with patients with Type 1 CNV, likely correlating to the intraretinal location of fibrin on ICGA in patients with Type 3 lesions. Color photograph after stabilization with intravitreal anti-VEGF therapy shows an irregular elevation of the RPE superotemporal to the fovea, pigment clumping, and drusen.…”

Indocyanine-green-guided targeted laser photocoagulation of capillary macroaneurysms in macular oedema: a pilot study

“…Since capillary macroaneurysms may show delayed ICG uptake,9 care was taken to capture late frames of ICGA, that is, after wash-out of the dye from large vessels. The presence of capillary macroaneurysms on ICGA was confirmed by colocalisation with a spherical structure presenting a clearly visible wall on OCT scans.…”

“…Massive hard exsudates may be observed, which show incomplete response by intravitreal injections 19–22. Interestingly, in our initial report of capillary macroaneurysms in diabetic macular oedema (DME) and RVO,9 all cases showed extensive HEs. We often observed that the centre of circinate deposits yielded the largest capillary macroaneurysms.…”

“…Indocyanine green angiography (ICGA) and optical coherence tomography (OCT) improve the detection of these lesions compared with FA 9 10. The amphiphilic properties of ICG11 may explain why ICG is more sensitive than the highly hydrophilic sodium fluorescein for the detection of capillary macroaneurysms since it may stain intraluminal fibrinogen.…”

Multimodal imaging in perifoveal exudative vascular anomalous complex with co‐existent diabetic retinopathy

“…Similar large micro‐aneurysms are often associated with other retinal vascular disorders like retinal vein occlusion and diabetic retinopathy . As a result, Sacconi et al had excluded eyes with other retinal vascular abnormalities from their study.…”