Imaging of cortical haemoglobin concentration with RGB reflectometry

Steimers, André; Gramer, Markus; Ebert, Bernd; Füchtemeier, Martina; Royl, Georg; Leithner, Christoph; Dreier, Jens P.; Lindauer, Ute; Kohl‐Bareis, Matthias

doi:10.1117/12.831583

Cited by 6 publications

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“…Another more reliable spectroscopic resolution is accomplished by combining a RGB (red, green, blue)-LED and a RGB-(colour) camera. It has already been shown that this RGB reflectometry approach is able to record small changes in haemoglobin oxygenation associated with neurometabolic and neurovascular coupling [4]. Here this approach is used in combination with laser speckle contrast analysis (LASCA) to enable a simultaneous mapping of both haemoglobin and blood flow changes.…”

Section: Introductionmentioning

confidence: 98%

Simultaneous imaging of haemoglobin oxygenation and blood flow with RGB reflectometry and LASCA during stroke in rats

et al. 2011

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We demonstrate the simultaneous mapping of haemoglobin oxygenation and blood flow changes of human skin and the exposed cortex in rats by broad-band reflectometry and laser speckle contrast analysis (LASCA). A hard-and software set-up is realized with a high temporal resolution achieved by techniques of multi-and manycore computing. Spatial and temporal resolved changes of haemoglobin oxygenation and blood flow in rats are observed in response to middle cerebral artery occlusion and cortical spreading depression.

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Section: Introductionmentioning

confidence: 98%

Simultaneous imaging of haemoglobin oxygenation and blood flow with RGB reflectometry and LASCA during stroke in rats

et al. 2011

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“…This is why even simple devices such as true color camera are often used for assistance or monitoring during surgical intervention or radiotherapy for a variety of body parts: brain [24], heart [27] or abdomen [34] for example. Analysis of videos from these camera can be used for brain surface strain estimation [15], brain surface 3D reconstruction [18,22], to investigate the deformation of the exposed cortical surface [16], to measure hemodynamic response [24,38,35,33,20]. In all these works, motion compensation is used during some stage of the processing workflow with general purpose routines such as Horn and Schunck [11] or Farnebäck [6] optical flow routines, demons registration [37] or the Matlab 1 Medical Image Registration Toolbox.…”

Section: Introductionmentioning

confidence: 99%

Repetitive motion compensation for real time intraoperative video processing

Sdika

Alston

Rousseau

et al. 2019

Medical Image Analysis

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In this paper, we present a motion compensation algorithm dedicated to video processing during neurosurgery. After craniotomy, the brain surface undergoes a repetitive motion due to the cardiac pulsation. This motion as well as potential video camera motion prevent accurate video analysis. We propose a dedicated motion model where the brain deformation is described using a linear basis learned from a few initial frames of the video. As opposed to other works using linear basis for the flow, the camera motion is explicitly accounted in the transformation model. Despite the nonlinear nature of our model, all the motion parameters are robustly estimated all at once, using only one singular value decomposition (SVD), making our procedure computationally efficient. A Lagrangian specification of the flow field ensures the stability of the method. Experiments on in vivo data are presented to evaluate the capacity of the method to cope with occlusion or camera motion. The method we propose satisfies the intraoperative constraints: it is robust to surgical tools occlusions, it works in real time, and it is able to handle large camera viewpoint changes.

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“…21,22 In some studies, a spectroscopic analysis of the intrinsic signal is computed to assess the cortical hemoglobin concentration changes. New approaches consist in using an RGB 21,23 or hyperspectral 18 camera with a continuous wave white light source 18,21,24 or pulsed narrow bandpass illumination sources. 23,25 These setups have the main advantages of being usable in real time 18,25 and directly in the operative room.…”

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confidence: 99%

“…New approaches consist in using an RGB 21,23 or hyperspectral 18 camera with a continuous wave white light source 18,21,24 or pulsed narrow bandpass illumination sources. 23,25 These setups have the main advantages of being usable in real time 18,25 and directly in the operative room. Steimers et al 23 analyzed an exposed rat cortex with an RGB-LED light source and an RGB camera.…”

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confidence: 99%

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Intraoperative quantitative functional brain mapping using an RGB camera

et al. 2019

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Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular, new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the computation of hemodynamics-based functional brain maps using an RGB camera and a white light source. We measure the quantitative oxy and deoxyhemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to evaluate the functional brain areas following neuronal activation by physiological stimuli. The results show a good correlation between the computed quantitative functional maps and the brain areas localized by electrical brain stimulation (EBS). We demonstrate that an RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in a robust way the functional areas during neurosurgery and serve as a tool of choice to complement EBS. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Imaging of cortical haemoglobin concentration with RGB reflectometry

Cited by 6 publications

References 0 publications

Simultaneous imaging of haemoglobin oxygenation and blood flow with RGB reflectometry and LASCA during stroke in rats

Simultaneous imaging of haemoglobin oxygenation and blood flow with RGB reflectometry and LASCA during stroke in rats

Repetitive motion compensation for real time intraoperative video processing

Intraoperative quantitative functional brain mapping using an RGB camera

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