Intraoperative quantitative functional brain mapping using an RGB camera

Caredda, Charly; Mahieu-Williame, Laurent; Sablong, Raphaël; Sdika, Michaël; Alston, Laure; Guyotat, Jacques; Montcel, Bruno

doi:10.1117/1.nph.6.4.045015

Cited by 17 publications

(32 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, in patients with stroke who underwent decompressive hemicraniectomy, continuous imaging of cortical microcirculatory dynamics was used to assess patterns of cortical spreading depression 71 and predict infarct territories. 72 Finally, IOS [73][74][75][76] and LSC 77 imaging of the microcirculatory response to external stimuli were used for functional mapping of the human brain. Together with electrocorticograms (ECoG), these optical imaging modalities can help identify crucial brain regions that directly control function and need to be preserved during neurosurgery.…”

Section: Op Tic Al Imag Ingmentioning

confidence: 99%

Advances in translational imaging of the microcirculation

et al. 2021

View full text Add to dashboard Cite

Since Johan Christophorous first described nailfold capillaroscopy in 1663 and Giovanni Rasori and Maurice Raynaud studied capillary changes in inflammation and ischemia in the 18th and 19th centuries, 1 interest in the microcirculation has grown significantly.Advances in imaging technologies over the past several decades have enabled clinicians and researchers to visualize and interrogate the microcirculation directly, or measure parameters, traces or indices that reflect the structural and functional status of the microcirculation. Several of these imaging technologies provide quantitative "readouts" that may directly or indirectly be employed as biomarkers. 2,3 Such noninvasive, imaging biomarkers have the potential to improve clinical assessment of the microcirculation and disease diagnosis, and enable long-term monitoring of treatment response. 4

show abstract

Section: Op Tic Al Imag Ingmentioning

confidence: 99%

Advances in translational imaging of the microcirculation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In this study, the imaging system represented in Figure 1 was simulated. This setup was used in our previous study [5] for the identification of functional areas based on RGB imaging. A continuous wave white light source illuminated the patient exposed cortex.…”

Section: Simulated Setupmentioning

confidence: 99%

“…However, this technique suffers from limitations because the measurements could trigger epilepsy seizures. Since optical imaging combined with a quantitative modeling of brain hemodynamic biomarkers could evaluate in real time the functional areas during neurosurgery [4][5][6], this technique could serve as a tool of choice to complement the electrical brain stimulation.…”

Section: Introductionmentioning

confidence: 99%

“…In comparison, a standard color camera (or RGB camera) acquires three colors (red, green, and blue) using broad and overlapping spectral detectors. Both techniques have the ability to measure the oxygenation changes in the tissue using the modified Beer-Lambert law [5,[8][9][10][11][12]. In functional brain mapping studies, the concentration changes of oxy-(∆C HbO 2 ) and deoxy-hemoglobin (∆C Hb )can be analyzed to identify the activated cortical areas [5,[13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…Both techniques have the ability to measure the oxygenation changes in the tissue using the modified Beer-Lambert law [5,[8][9][10][11][12]. In functional brain mapping studies, the concentration changes of oxy-(∆C HbO 2 ) and deoxy-hemoglobin (∆C Hb )can be analyzed to identify the activated cortical areas [5,[13][14][15][16][17][18][19][20][21]. The acquisition of the intrinsic signal in the near-infrared range offers the potential to monitor the brain metabolism with the quantification of the concentration changes of the oxidative state of cytochrome-c-oxidase (∆C oxCCO ) [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimal Spectral Combination of a Hyperspectral Camera for Intraoperative Hemodynamic and Metabolic Brain Mapping

et al. 2020

Self Cite

View full text Add to dashboard Cite

Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas are assessed by monitoring the oxygenated (HbO2) and deoxygenated hemoglobin (Hb) concentration changes occurring in the brain. Sometimes, the functional status of the brain is assessed using metabolic biomarkers: the oxidative state of cytochrome-c-oxidase (oxCCO). A setup composed of a white light source and a hyperspectral or a standard RGB camera could be used to identify the functional areas. The choice of the best spectral configuration is still based on an empirical approach. We propose in this study a method to define the optimal spectral combinations of a commercial hyperspectral camera for the computation of hemodynamic and metabolic brain maps. The method is based on a Monte Carlo framework that simulates the acquisition of the intrinsic optical signal following a neuronal activation. The results indicate that the optimal spectral combination of a hyperspectral camera aims to accurately quantify the HbO2 (0.5% error), Hb (4.4% error), and oxCCO (15% error) responses in the brain following neuronal activation. We also show that RGB imaging is a low cost and accurate solution to compute Hb maps (4% error), but not accurate to compute HbO2 (48% error) or oxCCO (1036% error) maps.

show abstract

Topographic Mapping of the Primary Sensory Cortex Using Intraoperative Optical Imaging and Tactile Irritation

Polanski¹,

Oelschlägel

Juratli³

et al. 2022

Brain Topogr

View full text Add to dashboard Cite

The determination of exact tumor boundaries within eloquent brain regions is essential to maximize the extent of resection. Recent studies showed that intraoperative optical imaging (IOI) combined with median nerve stimulation is a helpful tool for visualization of the primary sensory cortex (PSC). In this technical note, we describe a novel approach of using IOI with painless tactile irritation to demonstrate the feasibility of topographic mapping of different body regions within the PSC. In addition, we compared the IOI results with preoperative functional MRI (fMRI) findings. In five patients with tumors located near the PSC who received tumor removal, IOI with tactile irritation of different body parts and fMRI was applied. We showed that tactile irritation of the hand in local and general anesthesia leads to reliable changes of cerebral blood volume during IOI. Hereby, we observed comparable IOI activation maps regarding the median nerve stimulation, fMRI and tactile irritation of the hand. The tactile irritation of different body areas revealed a plausible topographic distribution along the PSC. With this approach, IOI is also suitable for awake surgeries, since the tactile irritation is painless compared with median nerve stimulation and is congruent to fMRI findings. Further studies are ongoing to standardize this method to enable a broad application within the neurosurgical community.

show abstract

Intraoperative quantitative functional brain mapping using an RGB camera

Cited by 17 publications

References 39 publications

Advances in translational imaging of the microcirculation

Advances in translational imaging of the microcirculation

Optimal Spectral Combination of a Hyperspectral Camera for Intraoperative Hemodynamic and Metabolic Brain Mapping

Topographic Mapping of the Primary Sensory Cortex Using Intraoperative Optical Imaging and Tactile Irritation

Contact Info

Product

Resources

About