Imaging in rheumatoid arthritis – status and recent advances for magnetic resonance imaging, ultrasonography, computed tomography and conventional radiography

Østergaard, Mikkel; Pedersen, Susanne Juhl; Døhn, Uffe Møller

doi:10.1016/j.berh.2008.09.014

Cited by 135 publications

(109 citation statements)

References 117 publications

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“…However, these methods are less sensitive – especially for the wrist evaluation- due to inter-reader variability [6]. For this reason, the computed tomography (CT) has become the most considered and sophisticated method based on its three-dimensional (3D) visualization of calcified tissue [7]. It allows acquiring high-resolution volume data in few seconds and providing detailed anatomical information, such as bone erosion, which can be assessed in frontal, sagittal and transversal planes [8].…”

Section: Introductionmentioning

confidence: 99%

A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

Achour

Bouaziz

Mechri

et al. 2018

Libyan Journal of Medicine

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The aim of our study was to assess the relationship between bone and cartilage remodeling biomarkers and joint damage in Rheumatoid Arthritis (RA), and to detect whether they have the capacity to predict the progression of joint disease assessment by computed tomography (CT) erosion score. We analyzed 65 female patients with established RA in our Rheumatology Department. Serum levels of bone and cartilage markers were measured: osteocalcin (OC), N-propeptide of type I collagen (PINP), collagen type I and II, C-telopeptide (CTX I, CTX-II) and cartilage oligomeric matrix protein (COMP). Radiography of both wrist and MCP joints were available. Two expert-readers independently scored articular damage and progression using the High-resolution low dose CT scan in a blinded fashion. 65 female patients with established RA with a median age of 44 years were included. The median disease-duration was two years and the median (Disease activity score) DAS 28 score at 4.46 [2.65–7.36]. The percentage of patient with low disease activity was 13.8%, while 55.4 and 30.8% for those with moderate and high disease activity respectively. The resorption bone markers were high in active versus non-active RA. Wrist and MCP erosion scores were also associated with RA activity. Our study shows that biomarkers of bone and cartilage collagen breakdown were related to specific joint erosion in RA and could predict subsequent radiographic damage in RA. Further larger scale longitudinal studies maybe needed to confirm our data.

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Section: Introductionmentioning

confidence: 99%

A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

Achour

Bouaziz

Mechri

et al. 2018

Libyan Journal of Medicine

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“…Other investigators have also demonstrated that MRI is a sensitive tool for the assessment of joint inflammation, especially in the early disease course (1,2). In the small joints of the hands and feet, Szkudlarek et al have also shown the superiority of contrast-enhanced MRI toward the detection of synovitis as compared with physical examination (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) has been postulated to be more sensitive than clinical examination for the detection of inflammatory and destructive joint changes in early-stage rheumatoid arthritis (RA) (1,2); however, a precise study regarding the accuracy of MRI-proven joint injury as compared with joint injury determined by physical examination remains to be clarified. Although Sugimoto et al have shown in an earlier study that MRI-proven synovitis is useful in diagnosing early-stage RA in conjunction with physical examination (3), there is a limitation about this report since a number of examinations were small and bone edema as well as bone erosion were not included.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the detection of joint injury in early‐stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination

Tamai¹,

Kawakami²,

Iwamoto³

et al. 2011

Arthritis Care & Research

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Objective. To verify whether magnetic resonance imaging (MRI)-proven joint injury is sensitive as compared with joint injury determined by physical examination. Methods. MRI of the wrist and finger joints of both hands was examined in 51 early-stage rheumatoid arthritis (RA) patients by both plain and gadolinium diethylenetriaminepentaacetic acid-enhanced MRI. Synovitis, bone edema, and bone erosion (the latter two included as bone lesions at the wrist joints); metacarpophalangeal joints; and proximal interphalangeal joints were considered as MRI-proven joint injury. Japan College of Rheumatology-certified rheumatologists had given a physical examination just before the MRI study. The presence of tender and/or swollen joints in the same fields as MRI was considered as joint injury on physical examination. The association of MRI-proven joint injury with physical examination-proven joint injury was examined. Results. A total of 1,110 sites were available to be examined. MRI-proven joint injury was found in 521 sites, whereas the other 589 sites were normal. Physical examination-proven joint injury was found in 305 sites, which was significantly low as compared with MRI-proven joint injury (P ‫؍‬ 1.1 ؋ 10 ؊12 versus MRI). Joint injury on physical examination was not found in 81.5% of the sites where MRI findings were normal. Furthermore, an association of the severity of MRI-proven joint injury with that of joint injury on physical examination was clearly demonstrated (P ‫؍‬ 1.6 ؋ 10 ؊15 , r s ‫؍‬ 0.469). Conclusion. Our present data suggest that MRI is not only sensitive but accurately reflects the joint injury in patients with early-stage RA.

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“…16 The use of paramagnetic contrast agents (gadolinium compounds) is formally indicated in patients with RA, potentiating the detection of synovial thickening and anomalously enhanced areas, indicative of infl ammatory activity in both soft tissues and bone; enhanced areas in medullary bone are seen even prior to the appearance of erosions and indicate increased risk for their development. 16 Erosions and the tenosynovial component of RA are also properly demonstrated on MRI, even with virtually normal radiographies. The CIMESTRA study has shown that the detection of bone edema on MRI in initial RA is the best predictor of radiographic progression of bone erosion after a two-year follow-up.…”

Section: Magnetic Resonancementioning

confidence: 99%

“…14,15 However, it is examiner dependent, has low reproducibility, and has not been completely standardized to assess initial RA. 16 It does not allow assessing changes deeply located in the joints. In addition, the ultrasound beam does not penetrate bone, and, thus, bone assessment is restricted to the cortical surface and available acoustic windows.…”

mentioning

confidence: 99%

Diagnóstico por imagem da artrite reumatoide inicial

Mota¹,

Laurindo²,

Neto³

et al. 2012

Rev. Bras. Reumatol.

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Early diagnosis of rheumatoid arthritis is essential for its proper management. Currently, the initial phase of rheumatoid arthritis is known to provide a window of therapeutic opportunity. Although the diagnosis is primarily clinical, the development and improvement of laboratory and imaging methods have contributed to earlier diagnosis and determination of procedures in early rheumatoid arthritis. In this article, the authors review the role of the major imaging methods used for assessing early rheumatoid arthritis, especially conventional radiography, ultrasonography, and magnetic resonance imaging.

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Imaging in rheumatoid arthritis – status and recent advances for magnetic resonance imaging, ultrasonography, computed tomography and conventional radiography

Cited by 135 publications

References 117 publications

A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

Comparative study of the detection of joint injury in early‐stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination

Diagnóstico por imagem da artrite reumatoide inicial

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