Imaging in Metastatic Renal Cell Carcinoma

Griffin, Nyree; Gore, Martin; Sohaib, S.A.

doi:10.2214/ajr.07.2077

Cited by 108 publications

(67 citation statements)

References 68 publications

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“…The detection of a normal adrenal gland at MDCT in patients with RCC has been associated with 100% negative predictive value for metastasis [90,91] .…”

Section: Stagingmentioning

confidence: 99%

“…Contrast-enhanced MDCT is more accurate than chest radiography to detect pulmonary metastasis early and is very sensitive for abdominal metastasis or retroperitoneal recurrences [90] .…”

Section: Stagingmentioning

confidence: 99%

“…MRI has been shown to be highly sensitive and specific in diagnosing bone metastasis, more than bone scintigraphy [90] . MRI is also more sensitive than CT for the detection of small cerebral metastases that can be treated by surgery or focal radiation therapy [5] .…”

Section: Diagnosis Of Primary Tumormentioning

confidence: 99%

“…In their largest series, Kang et al [134] reported that FDG-PET was less sensitive than CT in the detection of retroperitoneal lymph nodes and/or renal bed recurrence (75 vs FDG-PET showed higher diagnostic sensitivity and accuracy (100 and 100%, respectively) to detect bone metastases in patients with RCC when compared with bone scan (77.5 and 59.6%, respectively) [144] . Nevertheless, correlation with cross-sectional imaging is recommended because of a significant rate of false-negative results for both techniques [5,90] .…”

Section: Stagingmentioning

confidence: 99%

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Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Sacco¹,

Pinto²,

Totaro³

et al. 2010

Urol Int

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Background and Aim: Renal cell carcinoma (RCC) is the 13th most common cancer worldwide and accounts for 4% of all adult malignancies. Herein the state of the art and recent advances in cross-sectional radiological imaging applied to RCC are reviewed, including ultrasonography, computed tomography, magnetic resonance imaging, and positron emission tomography. Methods: Literature search of peer-reviewed papers published by October 2010. Results: In front of more conventional and widespread imaging tools, such as ultrasonography and computed tomography, an array of newer and attractive radiological modalities are under investigation and show promise to improve our ability to noninvasively detect renal tumors and its recurrences, accurately assess the extent of the disease, and reliably evaluate treatment response, particularly in the era of antiangiogenetic therapy. Conclusions: Recent major advances in radiological imaging techniques have considerably improved our ability to diagnose, stage and follow-up RCC. Further studies are needed to evaluate the potential of most recent and still investigational imaging tools.

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“…The detection of a normal adrenal gland at MDCT in patients with RCC has been associated with 100% negative predictive value for metastasis [90,91] .…”

Section: Stagingmentioning

confidence: 99%

“…Contrast-enhanced MDCT is more accurate than chest radiography to detect pulmonary metastasis early and is very sensitive for abdominal metastasis or retroperitoneal recurrences [90] .…”

Section: Stagingmentioning

confidence: 99%

Section: Diagnosis Of Primary Tumormentioning

confidence: 99%

Section: Stagingmentioning

confidence: 99%

See 2 more Smart Citations

Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Sacco¹,

Pinto²,

Totaro³

et al. 2010

Urol Int

View full text Add to dashboard Cite

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“…1 Several small series have noted the association between metastasectomy and prolonged survival 2,3 independent of other known risk factors, 4 although patients with a good performance status and a solitary site of metastasis or low volume disease appear to be ideal candidates for metastasectomy. Therefore, surgery may be recommended to patients with metachronous ipsilateral adrenal metastasis 5,6 either with or in the absence of systemic therapy.…”

mentioning

confidence: 99%

Laparoscopic Adrenalectomy for Metachronous Metastases After Ipsilateral Nephrectomy for Renal-Cell Carcinoma

Abel

Karam²,

Carrasco

et al. 2011

Journal of Endourology

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Background and Purpose: While laparoscopic adrenalectomy (LA) is considered the standard of care for removal of small adrenal masses, there are minimal data describing the feasibility and outcomes of LA after previous ipsilateral nephrectomy (PIN). The purpose of the study was to describe the perioperative outcomes in a series of patients who were undergoing LA after PIN. Patients and Methods: Using an institutional database, we identified patients who underwent LA since 2002 by a single surgeon. Clinical and pathologic data were collected and analyzed. To evaluate outcomes, patients undergoing LA after PIN were compared with patients undergoing LA without PIN. Results: Of 54 consecutive patients undergoing LA, 8 had PIN for renal-cell carcinoma (RCC). Estimated blood loss was not significantly greater in patients with PIN: 50 mL vs 100 mL, P = 0.109. Operative time was longer in patients with PIN: 120 minutes vs 156 minutes, P = 0.015. There was no difference in length of hospital stay between groups: Median 2 days for both groups, P = 0.635. One patient in the PIN group had a conversion to open adrenalectomy and needed blood transfusion. Perioperative complications were seen in 5/46 (10.6%) patients without and in 1/8 (12.5%) patients with PIN. Surgical margins were negative in all patients. Conclusions: To the authors' knowledge, this study represents the largest experience with adrenalectomy in the reoperative setting. LA after PIN is associated with a longer operative time. While the potential for conversion is possible, it is technically feasible in selected patients and thus far appears to be associated with similar perioperative outcomes compared with patients without PIN.

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