Imaging in chronic spinal cord injury—indications and benefits

Bodley, R

doi:10.1016/s0720-048x(02)00046-3

Cited by 42 publications

(30 citation statements)

References 74 publications

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“…No radiological investigations were done. The role of radiological investigations in pressure sore is significant in ruling out bone infection (11,12). Studies done by Esposito and Ziccardo (13) demonstrated validity of modern CT scanning as a main diagnostic method.…”

Section: Resultsmentioning

confidence: 99%

Pressure ulcers presentations and management at Kenyatta National Hospital and Spinal Injury Hospital

Nangole¹,

Khainga²,

Kiboi³

2010

E Af Med Jrnl

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Objective: To determine the presentation and management of patients with pressure ulcers. Design: A prospective study. Setting: The Kenyatta National Hospital (KNH) and National Spinal Injury Hospital (NSIH). Subjects: One hundred and thirteen patients were evaluated. Ninety six patients from KNH and seventeen from NSIH. Patients admitted at Kenyatta National Hospital and National Spinal Injury Hospital with pressure ulcers during the study period. Results: Of the 113 patients, 77 (68.1%) were male and 36 (31.9%) were female. Mean age of the patients studied was 38.1 years while the range was between 12 and 74 years. Paraplegia was the main associated medical condition accounting for 35.4%, followed by HIV/AIDS with 27.4%. The most common anatomical site for pressure ulcers was tronchanteric region with 43% of the ulcers. Pressure ulcers of grade III and IV accounted for 66.4% of the ulcers. Two hourly turning was the most common method of pressure dispersion used. Gauze dressing was the most common method used in wound care while 67.3% of the patients had their wounds cleaned with povidoneiodine. Fasciocutaneous flaps were the most common surgical procedure performed (81.7%) for closure of pressure ulcers. Overall, 59.3% of surgical procedures had been successful at one month. This was, however, reduced to 48.1% at three months. Conclusion: Majority of patients with pressure ulcers were in a relatively young age group with a mean age of 38 years. Most of the ulcers were located along bony prominence points of the pelvic girdle and the proximal femur. Most of the ulcers in this study were treated conservatively, with only a few ulcers subjected to surgical interventions. For the ulcers treated with surgical interventions the early outcome was good, however studies need to be done to determine long term outcomes.

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Section: Resultsmentioning

confidence: 99%

Pressure ulcers presentations and management at Kenyatta National Hospital and Spinal Injury Hospital

Nangole¹,

Khainga²,

Kiboi³

2010

E Af Med Jrnl

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“…[43][44][45] PROG reduced volume and length of T2 hyperintense signals when compared with SCI rats (Fig. 1A, B, C).…”

Section: Prog Reduced Secondary Damage and Increased Spared Tissuementioning

confidence: 86%

Progesterone Reduces Secondary Damage, Preserves White Matter, and Improves Locomotor Outcome after Spinal Cord Contusion

Garcı́a-Ovejero

GonzálezSusana²,

Paniagua-TorijaBeatriz³

et al. 2014

Journal of Neurotrauma

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Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model of spinal cord lesion (thoracic contusion). Using magnetic resonance imaging, we observed that progesterone reduced both volume and rostrocaudal extension of the lesion at 60 days post-injury. In addition, progesterone increased the number of total mature oligodendrocytes, myelin basic protein immunoreactivity, and the number of axonal profiles at the epicenter of the lesion. Further, progesterone treatment significantly improved motor outcome as assessed using the Basso-Bresnahan-Beattie scale for locomotion and CatWalk gait analysis. These data suggest that progesterone could be considered a promising therapeutical candidate for spinal cord injury.

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“…Forty percent of patients with SCI have complete loss of function below the level of injury and no functioning neural tissue at the level of the injury. 1,2 Proposed methods for bypassing this damaged area of spinal cord include robotic or electronic connections or replacing the scar and cystic areas with either a nervous tissue bridge or a synthetic bridge. 3,4 Biodegradable polymer scaffolds serve to form a structural support to bridge the injury site and guide axonal regeneration.…”

Section: Introductionmentioning

confidence: 99%

Neural Stem Cell– and Schwann Cell–Loaded Biodegradable Polymer Scaffolds Support Axonal Regeneration in the Transected Spinal Cord

Olson

Rooney

Gross

et al. 2009

Tissue Engineering Part A

152

143

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Biodegradable polymer scaffolds provide an excellent approach to quantifying critical factors necessary for restoration of function after a transection spinal cord injury. Neural stem cells (NSCs) and Schwann cells (SCs) support axonal regeneration. This study examines the compatibility of NSCs and SCs with the poly-lacticco-glycolic acid polymer scaffold and quantitatively assesses their potential to promote regeneration after a spinal cord transection injury in rats. NSCs were cultured as neurospheres and characterized by immunostaining for nestin (NSCs), glial fibrillary acidic protein (GFAP) (astrocytes), bIII-tubulin (immature neurons), oligodendrocyte-4 (immature oligodendrocytes), and myelin oligodendrocyte (mature oligodendrocytes), while SCs were characterized by immunostaining for S-100. Rats with transection injuries received scaffold implants containing NSCs (n ¼ 17), SCs (n ¼ 17), and no cells (control) (n ¼ 8). The degree of axonal regeneration was determined by counting neurofilament-stained axons through the scaffold channels 1 month after transplantation. Serial sectioning through the scaffold channels in NSC-and SC-treated groups revealed the presence of nestin, neurofilament, S-100, and bIII tubulin-positive cells. GFAP-positive cells were only seen at the spinal cord-scaffold border. There were significantly more axons in the NSC-and SC-treated groups compared to the control group. In conclusion, biodegradable scaffolds with aligned columns seeded with NSCs or SCs facilitate regeneration across the transected spinal cord. Further, these multichannel biodegradable polymer scaffolds effectively serve as platforms for quantitative analysis of axonal regeneration.

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Imaging in chronic spinal cord injury—indications and benefits

Cited by 42 publications

References 74 publications

Pressure ulcers presentations and management at Kenyatta National Hospital and Spinal Injury Hospital

Pressure ulcers presentations and management at Kenyatta National Hospital and Spinal Injury Hospital

Progesterone Reduces Secondary Damage, Preserves White Matter, and Improves Locomotor Outcome after Spinal Cord Contusion

Neural Stem Cell– and Schwann Cell–Loaded Biodegradable Polymer Scaffolds Support Axonal Regeneration in the Transected Spinal Cord

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