Imaging Gastric Cancer with PET and the Radiotracers 18F-FLT and 18F-FDG: A Comparative Analysis

Herrmann, Ken; Ott, Katja; Buck, Andreas K.; Lordick, Florian; Wilhelm, Dirk; Souvatzoglou, Michael; Becker, Karen; Schuster, Tibor; Wester, Hans‐Jürgen; Siewert, J. R.; Schwaiger, Markus; Krause, Bernd J.

doi:10.2967/jnumed.107.044867

Cited by 116 publications

(107 citation statements)

References 21 publications

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“…To the best of our knowledge, this is the first study to assess the FDG uptake characteristics of the primary tumor according to the WHO, Lauren, Ming and Borrmann histopathologic classifications in the same patients with advanced gastric cancer. Several studies have reported lower FDG uptake in the diffuse type than in the intestinal type according to the Lauren classification [20,29,30]. Although a few studies have reported no significant differences because of different study populations compared with those in the present study, the FDG uptake and detection rate of the diffuse type were lower than those of the intestinal type [31,32].…”

Section: Discussioncontrasting

confidence: 69%

Correlation of Primary Tumor FDG Uptake with Histopathologic Features of Advanced Gastric Cancer

Kim

Won

Song

et al. 2015

Nucl Med Mol Imaging

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Purpose Histopathologic features could affect the FDG uptake of primary gastric cancer and detection rate on FDG PET/CT. The aim of this study was to evaluate the FDG uptake of primary gastric cancer by correlating it with the histopathologic features of the tumors. Methods Fifty patients with locally advanced gastric adenocarcinoma who were referred for preoperative FDG-PET/CT scans were enrolled in this study. The detection rate of PET/ CT and maximum standardized uptake values (SUV max ) of the primary tumor were compared using the WHO, Lauren, Ming and Borrmann classifications and tumor size and location. Results In 45 of the 50 patients (90 %), the primary gastric tumors were detected by FDG PET/CT. On comparison using the WHO classification, the detection rate and SUV max of the tubular type were significantly higher than those of the poorly cohesive type. On comparison using the Lauren and Ming classifications, the SUV max s of the intestinal type and expanding type were significantly higher than those of the diffuse and infiltrative type, respectively. On comparison using the Borrmann classification and tumor size and location, there was no significant difference in the detection rate and SUV max of primary gastric tumors. Conclusion This study demonstrates that the poorly cohesive type according to the WHO classification, diffuse type according to the Lauren classification and infiltrative type according to the Ming classification have low FDG uptake in patients with locally advanced gastric carcinoma. Understanding the relationship between primary tumor FDG uptake and histopathologic features would be helpful in detecting the primary tumor by FDG PET/CT in patients with gastric cancer.

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Section: Discussioncontrasting

confidence: 69%

Correlation of Primary Tumor FDG Uptake with Histopathologic Features of Advanced Gastric Cancer

Kim

Won

Song

et al. 2015

Nucl Med Mol Imaging

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“…Similar to colon and esophageal cancers, gastric cancer has shown lower uptake of 18 F-FLT than of 18 F-FDG (48). In a series of 45 gastric cancer patients, 18 F-FLT and 18 F-FDG PET were performed.…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

PET Imaging of Proliferation with Pyrimidines

Tehrani

Shields

2013

J Nucl Med

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“…Although most GEJ tumors are fluorodeoxyglucose (FDG)-avid, up to 30% of gastric cancers are non-avid and cannot be visualized by FDG-PET [63]. Use of alternative radioisotopes such as fluorothymidine may improve sensitivity of PET-CT in gastric cancer [64].…”

Section: Future Directionsmentioning

confidence: 99%