Imaging Findings of Fibrous Dysplasia with Histopathologic and Intraoperative Correlation

Fitzpatrick, Kimberly A.; Taljanovic, Mihra S.; Speer, Donald P.; Graham, Anna R.; Jacobson, Jon A.; Barnes, George; Hunter, Tim B.

doi:10.2214/ajr.182.6.1821389

Cited by 218 publications

(173 citation statements)

References 7 publications

(7 reference statements)

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“…Lesions of fibrous dysplasia associated with McCune-Albright syndrome tend to be more disabling than those of pure polyostotic disease. 9 The abnormal pigmentation often found in the skin overlying the lesions of fibrous dysplasia is a consequence of the development of melanotic macules. 5 These cutaneous lesions are flat pigmented macules, often referred to as café au lait spots and likened to the coast of Maine because of their irregular contour.…”

Section: Syndromes and Malignant Transformationsmentioning

confidence: 99%

Fibrous dysplasia of bone: a clinicopathologic review

Mohan¹

2011

PLMI

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Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gsα and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.

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Section: Syndromes and Malignant Transformationsmentioning

confidence: 99%

Fibrous dysplasia of bone: a clinicopathologic review

Mohan¹

2011

PLMI

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“…Degree of haziness shown radiographically in given fibrous dysplasia lesion directly correlates with its underlying histopathologic condition. The areas with more radiolucent lesions were composed of predominantly fibrous tissue; on the other hand more radiopaque lesions contain greater proportion of woven bone [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes bone lesions particularly in skull regions are not accessible to biopsy. So in those cases the diagnosis rests on classical radiological findings [14].…”

Section: Discussionmentioning

confidence: 99%

Polyostotic Fibrous Dysplasia of Maxillofacial Region: A Case Report

Agarwal¹

2017

J Interdiscipl Med Dent Sci

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Conditions in which normal bone is replaced with fibrous tissue containing abnormal bone or cementum constitute group of pathologies bone dysplasias. These pathologies should be differentiated from tumours, because the treatments of these pathologies are very different. Types of Fibrous dysplasia are monostotic, polyostotic or may occur as a component of McCune-Albright syndrome and Mazabraud syndrome. The most commonly affected bones are long bones, skull bones and ribs are. We present a case of polyostotic fibrous dysplasia in a 25 years old male patient.

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“…Fibrous dysplasia (FD) is a developmental skeletal anomaly in which osteoblasts do not undergo normal morphological differentiation and maturation, leading to the replacement of normal marrow and cancellous bone by immature bone and fibrous stroma (4,5). Between 6 and 20% of monostotic FD occurs in the ribs, with the second rib being most commonly affected (6).…”

Section: Introductionmentioning

confidence: 99%

Thoracoscopy-assisted first rib resection for the treatment of thoracic outlet syndrome caused by fibrous dysplasia: A report of two cases

Rehemutula

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. This study reports two rare cases of thoracic outlet syndrome (TOS) caused by fibrous dysplasia of the first rib. Two patients, aged 19 and 29 years old, were admitted with TOS in the lower trunk of the brachial plexus caused by an inflated first rib. In these two cases symptoms included hypoesthesia of the anterior medial aspect of the forearm and two fingers in the ulnar side, and progressive weakness of the upper limbs. Surgery was required to resect the first rib. Transaxillary and supraclavicular excisions were challenging to perform due to the involvement of the subclavian vasculature and brachial plexus. Thoracoscopy was used in these cases in order to peel the pleura off the first rib and facilitate resection by the supraclavicular approach. None of the patients exhibited nerve or vascular complications following the surgery.

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Imaging Findings of Fibrous Dysplasia with Histopathologic and Intraoperative Correlation

Cited by 218 publications

References 7 publications

Fibrous dysplasia of bone: a clinicopathologic review

Fibrous dysplasia of bone: a clinicopathologic review

Polyostotic Fibrous Dysplasia of Maxillofacial Region: A Case Report

Thoracoscopy-assisted first rib resection for the treatment of thoracic outlet syndrome caused by fibrous dysplasia: A report of two cases

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