Polyostotic Fibrous Dysplasia of Maxillofacial Region: A Case Report

Abstract

Conditions in which normal bone is replaced with fibrous tissue containing abnormal bone or cementum constitute group of pathologies bone dysplasias. These pathologies should be differentiated from tumours, because the treatments of these pathologies are very different. Types of Fibrous dysplasia are monostotic, polyostotic or may occur as a component of McCune-Albright syndrome and Mazabraud syndrome. The most commonly affected bones are long bones, skull bones and ribs are. We present a case of polyostotic fibrous dysplasia in a 25 years old male patient.

Maxillofacial fibrous dysplasia—diagnosis, treatment and reconstruction with a personalized, 3D-printed titanium implant: a case report

“…The etiology of FD is not fully explained, but today, the most popular idea is that it might be connected with a mutation in the GNAS1 gene that is responsible for coding the subunit Gsα of the stimulatory G protein, and its locus is on chromosome 20q13.2-13.3 [43,44]. As a result of these postzygotic mutations, the arginine residue amino acid is replaced with either a cysteine or a histidine amino acid [45,46]. Dysplastic features are revealed in all cells affected by this mutation.…”