Imaging Diagnosis of Central Nervous System Damage in Patients with T2DM

Zhang, Weiting; Zhao, Weina; Wang, Jialiang; Xu, Qing; Li, Siou; Yin, Changhao

doi:10.1016/j.neulet.2020.135092

Cited by 5 publications

(11 citation statements)

References 4 publications

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“…Fisher's Z transformation was used to obtain the Z score matrix of 116 × 116 in order to bring the function matrix closer to the normal distribution. Furthermore, because the small world network is sparse, this study set the sparsity range to 0.05–0.5 and the step size to 0.01, resulting in the construction of a weighted brain functional network for each subject (Zhang et al, 2020 ). The GretnaV2.0.0 software ( https://www.nitrc.org/projects/gretna/ ) was used to calculate the commonly used global and node attribute indicators in the NCs and LLD functional brain networks (including the LLD baseline and follow-up groups).…”

Section: Methodsmentioning

confidence: 99%

Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment

Liu

Li²,

Pan³

et al. 2023

Front. Aging Neurosci.

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ObjectivesTo preliminarily explore the functional activity and information integration of the brains under resting state based on graph theory in patients with first-episode, late-life depression (LLD) before and after antidepressant treatment.MethodsA total of 50 patients with first-episode LLD and 40 non-depressed controls (NCs) were recruited for the present research. Participants underwent the RBANS test, the 17-item Hamilton depression rating scale (HAMD-17) test, and resting-state functional MRI scans (rs-fMRI). The RBANS test consists of 12 sub-tests that contribute to a total score and index scores across the five domains: immediate memory, visuospatial/constructional, language, attention, and delayed memory. Escitalopram or sertraline was adopted for treating depression, and the dosage of the drug was adjusted by the experienced psychiatrists. Of the 50 LLD patients, 27 cases who completed 6-month follow-ups and 27 NCs matched with age, sex, and education level were included for the final statistical analysis.ResultsThere were significant differences in RBANS total score, immediate memory, visuospatial/constructional, language, attention, and delayed memory between LLD baseline group and NCs group (P < 0.05). Considering the global attribute indicators, the clustering coefficient of global indicators was lower in the LLD baseline group than in the NCs group, and the small-world attribute of functional brain networks existed in all three groups. The degree centrality and node efficiency of some brains were lower in the LLD baseline group than in the NCs group. After 6 months of antidepressant therapy, the scores of HAMD-17, immediate memory, language, and delayed memory in the LLD follow-up group were higher than those in the LLD baseline group. Compared with the LLD baseline group, the degree centrality and node efficiency of some brains in the cognitive control network were decreased in the LLD follow-up group.ConclusionsThe ability to integrate and divide labor of functional brain networks declines in LLD patients and linked with the depression severity. After the relief of depressive symptoms, the small-world attribute of functional brain networks in LLD patients persists. However, the information transmission efficiency and centrality of some brain regions continue to decline over time, perhaps related to their progressive cognitive impairment.

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Section: Methodsmentioning

confidence: 99%

Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment

Liu

Li²,

Pan³

et al. 2023

Front. Aging Neurosci.

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show abstract

“…The results of the present study show that whole‐brain networks in both patients with DON and HC subjects showed efficient small‐world topology, consistent with previous reports. 28 , 29 Nonetheless, there were differences between the 2 groups in small‐world parameters and nodal properties. Changes in global network properties in DON patients suggested a breakdown of the normal balance in functional networks caused by a decrease in long‐distance functional connections mainly involving the auditory network and DMN.…”

Section: Discussionmentioning

confidence: 96%

“…DC reflects the significance of nodes in the brain network, whereas NE and NLE are related to local information integration and transmission capacity. 29 , 30 …”

Section: Discussionmentioning

confidence: 99%

“…27 The results of the present study show that whole-brain networks in both patients with DON and HC subjects showed efficient small-world topology, consistent with previous reports. 28,29 Nonetheless, there were differences between the 2 groups in small-world parameters and nodal properties.…”

Section: Comparative Graph Theoretical Analysismentioning

confidence: 95%

“…reflects the significance of nodes in the brain network, whereas NE and NLE are related to local information integration and transmission capacity. 29,30 The thalamus has structural and functional connections with multiple cortical regions and participates in the filtering of sensory information from receptors, which is then projected to target cortical regions. In this manner, the thalamus plays an important role in language, emotion processing, and executive functions.…”

Section: F I G U R Ementioning

confidence: 99%

See 2 more Smart Citations

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Wei,

Lin,

et al. 2024

CNS Neurosci Ther

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AimsThis study aimed to investigate the resting‐state functional connectivity and topologic characteristics of brain networks in patients with diabetic optic neuropathy (DON).MethodsResting‐state functional magnetic resonance imaging scans were performed on 23 patients and 41 healthy control (HC) subjects. We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.ResultsCompared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN‐L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.ConclusionDON patients altered node properties and connectivity in the DMN, auditory network, FPN‐L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.

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Altered topological properties and their relationship to cognitive functions in unilateral temporal lobe epilepsy

Ma¹,

Zhang²,

Song³

et al. 2023

Epilepsy & Behavior

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Imaging Diagnosis of Central Nervous System Damage in Patients with T2DM

Cited by 5 publications

References 4 publications

Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment

Altered topological properties of functional brain networks in patients with first episode, late-life depression before and after antidepressant treatment

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Altered topological properties and their relationship to cognitive functions in unilateral temporal lobe epilepsy

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