Altered topological properties and their relationship to cognitive functions in unilateral temporal lobe epilepsy

Ma, Keran; Zhang, Xiaonan; Song, Chengru; Han, Shaoqiang; Li, Wenbin; Wang, Kefan; Mao, Xinyue; Zhang, Yihe; Cheng, Jingliang

doi:10.1016/j.yebeh.2023.109247

Cited by 1 publication

(1 citation statement)

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“…And then, to enhance our understanding, we employed graph theory analysis to assess task-state fMRI, a powerful tool that quantitatively examines functional brain networks’ nodes and edges. 16 While graph theory analysis has primarily been applied to resting-state fMRI data, 17 its utility in task-fMRI is promising and reliable. Deuker et al demonstrated the high reliability of graph theory during working memory tasks using magnetoencephalography data.…”

Section: Introductionmentioning

confidence: 99%

Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease

Guo,

Wu,

Zheng

et al. 2024

JIR

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Background Inflammatory Bowel Disease (IBD) patients may experience cognitive impairments in Visuospatial Working Memory (VSWM), significantly impacting their quality of life. However, the mechanisms underlying these impairments remain poorly understood. Methods We studied functional MRI and graph theory analysis to investigate changes in functional connectivity networks during the Mental Rotation Task (MRT) in IBD patients. Twenty IBD patients (13 males, 7 females; mean age = 34.95 ± 13.80 years; mean disease duration = 2.43 ± 2.37 years) participated in the study. Exclusion criteria encompassed recent use of analgesics, 5-Aminosalicylate, corticosteroids, or immunosuppressants within the past three months. Additionally, we recruited 20 age-, gender-, and education-matched healthy controls for comparison. Results Compared to a control group, IBD patients exhibited significantly longer reaction times and reduced accuracy during the MRT. Our analysis revealed abnormalities in multiple nodal attributes within the functional connectivity network, particularly in regions such as the bilateral orbitofrontal cortex, right supplementary motor area, bilateral parahippocampal gyrus, and bilateral anterior temporal lobe. We observed that the nodal efficiency in the left temporal pole is negatively correlated with Red Blood Cell Distribution Width (RDW) and positively correlated with response time of MRT. Conclusion Our findings revealed notable abnormalities in multiple node attributes among IBD patients during MRT, providing evidence of cognitive impairments in VSWM in IBD patients. This study found RDW maybe can serve as a clinical indicator for predicting early VSWM impairment in patients with IBD.

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Section: Introductionmentioning

confidence: 99%