Imaging characteristics of primary intracranial teratoma

Liu, Zhenyin; Lv, Xiaofei; Wang, Wensheng; An, Jie; Fuhong, Duan; Feng, Xiaoyuan; Chen, Xinjian; Ouyang, Bing; Songtao, Li; Singh, Satyakam; Qiu, Shuqing

doi:10.1177/0284185113507824

Cited by 42 publications

(33 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Criteria for inclusion in the iGM group were: 1) Pathologically confirmed diagnosis of intracranial germinoma; 2) Serum AFP level < 8.1 ng/mL (a common cutoff value for germinomas in the Chinese population [ 32 ]); 3) No intratumor hemorrhage or teratoma on pretreatment MRI and/or CT [ 33 , 34 ]; 4) Serum β-HCG level < 100mIU/mL; 5) Diagnostic radiotherapy with a dose of 20 Gy in the tumor area followed by MRI indicating the tumor size decreased by more than 50% [ 35 ]; and 6) In the case of residual tumor after radiotherapy, the residual tumor resolve during follow-up. Criteria for a pathological diagnosis were 1) and 2), while criteria for a clinical diagnosis were 2), 3), 4), 5), and 6).…”

Section: Methodsmentioning

confidence: 99%

Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas

Zhang

Fan

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundBeta (β)-human chorionic gonadotropin (β-HCG) is used to confirm the diagnosis and plan treatment of intracranial germinomas. However, the cutoff values of serum β-HCG in diagnosis of intracranial germinomas reported in the literature are inconsistent. To establish an appropriate cutoff value of serum β-HCG for diagnosis of intracranial germinomas, we retrospectively reviewed the records of intracranial tumor patients who received serum β-HCG and α-fetoprotein (AFP) tests for diagnostic purposes at our hospital from 2005 to 2014.MethodsA total of 93 intracranial germinomas and 289 intracranial non-germ cell tumors were included in this study. Receiver operating characteristic (ROC) analysis was used to evaluate the sensitivity and specificity of 3 cutoffs (0.1, 0.4, and 0.5 mIU/mL) for diagnosing intracranial germinomas. The serum β-HCG level of intracranial germinoma patients was further analyzed to investigate the effect of metastasis status and tumor location on serum β-HCG level.ResultsThe area under the ROC curve was 0.81 (P < .001), suggesting β-HCG is an effective marker. Of the 3 cutoff values, 0.1 mIU/mL possessed a highest sensitivity (66.67%) and good specificity (91%). Although there was no β-HCG level difference between metastatic and non-metastatic intracranial germinoma patients, the diagnostic rate of metastatic neurohypophyseal germinomas was significantly higher than that of its non-metastatic counterpart (P < .05), implying that the location of the germinoma might need to be considered when β-HCG is used as a marker to predict metastasis.ConclusionsDetermining an optimal cutoff of serum β-HCG is helpful for assisting the diagnosis of intracranial germinoma.

show abstract

Section: Methodsmentioning

confidence: 99%

Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas

Zhang

Fan

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…enhanced ring of PTMC nodular is incomplete), incomplete thyroid capsule (i.e. defined as the imaging findings of PTMC invasion outside the thyroid capsule), microcalcification (calcification with diameter < 2.0 mm), and enhanced degree of the region of interest (ROI) in arterial phase (mild and moderate enhancement when the net increased CT value was ≤ 40 HU, and significant enhancement when it was > 40 HU) (10).…”

Section: Analysis Of Morphological Features and Quantitative Parametementioning

confidence: 99%

Diagnostic Value of Dual-Energy CT Iodine for Characterization of Papillary Thyroid Microcarcinoma and Better Prediction of Metastatic Cervical Lymph Nodes

et al. 2020

View full text Add to dashboard Cite

Background: The preoperative assessment of cervical lymph node metastasis (LNM) is considered a challenging clinical problem in papillary thyroid microcarcinoma (PTMC) patients. Ultrasonic examination is significant for the cervical LNM in PTMC patients, but there are difficulties and limitations in observing lymph nodes in the cervical central region. Objectives: To investigate the diagnostic value of dual-energy CT iodine for characterization of PTMC and better prediction of metastatic cervical lymph nodes of PTMC. Patients and Methods: Ninety-five patients with PTMC who underwent dual energy (DE) CT examinations were retrospectively enrolled in the study. The iodine image morphological features of primary tumor were analyzed in the arterial phase and quantitative DECT parameters of the primary tumor were recorded in the arterial and venous phase. Chi-square test and independent-sample t test were performed to compare the differences of morphological features and quantitative parameters of tumors between LNM and non-LNM groups. Receiver operating characteristic curves were generated to assess the diagnostic performance of each DECT parameter and their combinations. Results: Six primary tumor morphological features of the LNM group demonstrated significant differences compared with the non-LNM group (all p < 0.05). Normalized iodine concentration (NIC) and normalized CT value in the LNM group were significantly higher than those of the non-LNM group in both arterial and venous phase, respectively (all p < 0.001). The area under the curve (AUC) was improved from 0.814 to 0.843 after adding maximum diameter compared with incomplete thyroid capsule alone. In addition, the combination of NICs in arterial and venous phases had higher AUC than other quantitative parameters. Conclusions: Morphological features and quantitative parameters of DECT are valuable for predicting cervical LNM in patients with PTMC.

show abstract

“…The second most common type of germ cell tumour behind a germinoma. They occur in children, with a greater frequency in boys, accounting for 0.5-1.5 % of all childhood brain tumours, and >50 % of intracranial tumours in infants less than 2 months [ 54 , 55 ]. Histologically, they demonstrate benign or malignant types, composed of derivatives of ectoderm, mesoderm and/or endoderm.…”

Section: Juxtasellar Lesionsmentioning

confidence: 99%

“…Marked enhancement of the solid portions of the tumour is a key feature in distinguishing a mature versus a malignant teratoma, with malignant tumours demonstrating enhancement. Additionally, they typically present without perilesional high T2 signal due to intact capsules and an undamaged blood-brain barrier [ 55 ]. They may contain calcifications with low signal on T1WI and T2WI.…”

Section: Juxtasellar Lesionsmentioning

confidence: 99%

Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review

et al. 2015

View full text Add to dashboard Cite

The sellar and juxtasellar regions in the paediatric population are complex both anatomically and pathologically, with magnetic resonance imaging (MRI) being the “gold standard” imaging modality due to the high contrast of detail. Assessment requires a detailed understanding of the anatomy, embryology, pathophysiology and normal signal characteristics of the pituitary gland and surrounding structures in order to appropriately characterise abnormalities. This article aims to provide an overview of the imaging characteristics of developmental/congenital and acquired disease processes which affect the sellar and juxtasellar region in the paediatric population.Main Messages• The sellar region is anatomically complex and covers a wide pathology spectrum.• MRI is the key imaging modality to assess sellar and juxtasellar pathology.• Numerous developmental anomalies may not be discovered until adulthood.• Knowledge of pathology alerts and guides the clinician towards appropriate management.

show abstract

Imaging characteristics of primary intracranial teratoma

Cited by 42 publications

References 19 publications

Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas

Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas

Diagnostic Value of Dual-Energy CT Iodine for Characterization of Papillary Thyroid Microcarcinoma and Better Prediction of Metastatic Cervical Lymph Nodes

Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review

Contact Info

Product

Resources

About