Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Brooksby, Ben; Pogue, Brian W.; Jiang, Shudong; Dehghani, Hamid; Srinivasan, Subhadra; Kogel, Christine; Tosteson, Tor D.; Weaver, John B.; Poplack, Steven P.; Paulsen, Keith D.

doi:10.1073/pnas.0509636103

Cited by 224 publications

(220 citation statements)

References 39 publications

(45 reference statements)

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“…To enhance the DOT reconstruction, anatomical priors were introduced. 25 33, 35 Zhu and colleagues used ultrasound imaging to guide the DOT imaging. 18,36 These studies have shown substantial improvements in quality and accuracy of DOT imaging with structural priors.…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

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Abstract. Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as hemoglobin, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer imaging. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at the wavelength of 650 nm and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements and width of measurement patch, have been investigated. Our results indicate that an air-cooling EMCCD camera is good enough for the transmission mode DOT imaging. We have also found that measurements at six angular projections are sufficient for DOT to reconstruct the optical targets with 2 and 4 times absorption contrast when the CT guidance is applied. Finally, we have described our future research plan on integration of a multispectral DOT imaging system into a breast CT scanner.

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Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Baikejiang

Zhang

2017

XST

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“…However, the image quality is inherently low, because the problem is usually nonlinear, ill-posed and underdetermined because of the diffusive nature of the photon migration. In addition to improving the forward and inverse models, recently, combining DOT with a highresolution structure-oriented imaging modality, such as MRI or ultrasound, has been reported to successfully improve image resolution and accuracy [83][84][85]. Although the development of DOT is extremely difficult, recent technological and methodological advances are encouraging.…”

Section: (B) Time-resolved Domain Diffuse Optical Tomographymentioning

confidence: 99%

Towards the next generation of near-infrared spectroscopy

Hoshi

2011

Phil. Trans. R. Soc. A.

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Although near-infrared spectroscopy (NIRS) was originally designed for clinical monitoring of tissue oxygenation, it has also been developing into a useful tool for neuroimaging studies (functional NIRS). Over the past 30 years, technology has developed and NIRS has found a wide range of applications. However, the accuracy and reliability of NIRS have not yet been widely accepted, mainly because of the difficulties in selective and quantitative detection of signals arising in cerebral tissue, which subject the use of NIRS to a number of practical restrictions. This review summarizes the strengths and advantages of NIRS over other neuroimaging modalities and demonstrates specific examples. The issues of selective quantitative measurement of cerebral haemoglobin during brain activation are also discussed, together with the problems of applying the methods of functional magnetic resonance imaging data analysis to NIRS data analysis. Finally, near-infrared optical tomography-the next generation of NIRS-is described as a potential technique to overcome the limitations of NIRS.

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“…10 Tomography-based systems, in comparison, are able to provide deeper three-dimensional ͑3D͒ volumetric maps of the Fl distribution and provide a modest amount of spatial resolution, with improved sensitivity to quantify lower contrasts. 11,12 In this study a new Fl tomography ͑FT͒ system that couples with microCT x-ray imaging is presented and its functionality is demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…In this work, the customized instrumentation was designed to allow fully noncontact parallel detection of the Fl and Tr measurements to resolve these data acquisition issues. Studies of a priori approaches to diffuse tomography have been ongoing for sometime, 12,20,21 with promising results shown for imaging of breast cancers [22][23][24] and small animals. 25 Yet diffuse imaging is plagued by low resolution recovery of the interior because the reconstruction problem is an ill-posed inversion problem.…”

Section: Introductionmentioning

confidence: 99%

A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging

Kepshire

Mincu²,

Hutchins³

et al. 2009

Review of Scientific Instruments

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A prototype small animal imaging system was created for coupling fluorescence tomography ͑FT͒ with x-ray microcomputed tomography ͑microCT͒. The FT system has the potential to provide synergistic information content resultant from using microCT images as prior spatial information and then allows overlay of the FT image onto the original microCT image. The FT system was designed to use single photon counting to provide maximal sensitivity measurements in a noncontact geometry. Five parallel detector locations are used, each allowing simultaneous sampling of the fluorescence and transmitted excitation signals through the tissue. The calibration and linearity range performance of the system are outlined in a series of basic performance tests and phantom studies. The ability to image protoporphyrin IX in mouse phantoms was assessed and the system is ready for in vivo use to study biological production of this endogenous marker of tumors. This multimodality imaging system will have a wide range of applications in preclinical cancer research ranging from studies of the tumor microenvironment and treatment efficacy for emerging cancer therapeutics.

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Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Cited by 224 publications

References 39 publications

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Diffuse optical tomography for breast cancer imaging guided by computed tomography: A feasibility study

Towards the next generation of near-infrared spectroscopy

A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging

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