Imaging Biomarkers for Monitoring the Inflammatory Redox Landscape in the Brain

Fernandes, Eduardo Felipe Alves; Özcelik, Dennis

doi:10.3390/antiox10040528

Cited by 9 publications

(5 citation statements)

References 193 publications

(116 reference statements)

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“…The lead, cadmium, and nickel in the blood cause inflammatory changes and affect the balance of neurotransmitters. MAO can be used to assist in the diagnosis of brain abnormalities in combination with brain imaging [64]. The MOA-B analysis identifies changes from the molecular level to the effect of altered behavior.…”

Section: Multivariate Covariance Analysis Of the Monoamine Oxidase (M...mentioning

confidence: 99%

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Harasarn

Phatrabuddha

Kaewkaen

et al. 2022

Rocz Panstw Zakl Hig

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Background. E-waste sorting workers usually separate electronic waste. Therefore, they can be exposed to heavy metals. Objectives. This study compared monoamine oxidase (MAO) levels affected by the levels of lead (Pb), cadmium (Cd), and nickel (Ni) in the blood and their workplace among e-waste sorting workers (EWSW). Material and methods. The exposed group included 76 EWSW, and the non-exposed group included 49 village health volunteers. An interview form was used to assess the risk factors. We measured Pb, Cd, and Ni on the work surfaces and in the blood, and MAO levels as a neurological enzymes. Results. Among the EWSW, 42 were males (55.3%), and the mean age (SD) 48.0 (12.64) years, and income were 156.37 ± 88.08 USD. In the work areas of the exposed group, the concentration of Pb, Cd, and Ni were 245.042 (± 613.910), 0.375 (± 0.662), and 46.115 (± 75.740) μg/100 cm2, respectively, while the non-exposed group, the concentration of Pb, Cd, and Ni were 0.609 (± 0.934), 0.167 (± 1.171) and 1.020 (± 0.142) μg/100 cm2. Pb and Ni concentrations in the workplace of the exposed groups were statistically different from that of the non-exposed group. Pb, Cd, and Ni concentrations in serum were 6.411 ± 1.492 μg/dL, 0.9480 ± 0.350 μg/L, 2.568 ± 0.468 μg/L, respectively, while in the non-exposed group, the heavy metal concentrations were 6.411 ± 1.620 μg/dL, 0.909 ± 0.277 μg/L, 2.527 ± 0.457 μg/L. The MAO in the exposed group was 362.060 ± 97.981 U/L, while that in the non-exposed group was 369.771 ± 86.752 U/L. Moreover, MAO concentration was significantly different from Ni concentration (p < 0.05). Conclusion. The electronic waste sorting workers should clean their work areas to reduce the Pb, Cd, and Ni levels on the working surfaces, and health surveillance should be performed.

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Section: Multivariate Covariance Analysis Of the Monoamine Oxidase (M...mentioning

confidence: 99%

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Harasarn

Phatrabuddha

Kaewkaen

et al. 2022

Rocz Panstw Zakl Hig

View full text Add to dashboard Cite

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“…On the other hand, oxidative stress can interact with individual signalling pathways, which may be more closely related to the detrimental effect and specificity of outer stimuli. In the nervous system, for example, the glial fibrillary acidic protein (GFAP) is known as a neurotoxicity biomarker (Shiyntum et al, 2017;Abdel Salam, 2021) which is obviously connected with the ROS production (Gasso et al, 2020a;Fernandes & Özcelik, 2021). On the other hand, the inflammation is an important part of innate defence against infectious agents as well as xenobiotic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Low doses of imidacloprid induce disruption of intercellular adhesion and initiate proinflammatory changes in Caco-2 cells

Nedzvetsky

Масюк

Gasso

et al. 2021

Regul. Mech. Biosyst.

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Imidacloprid is the most widely used pesticide of the neonicotinoid class. Neonicotinoid toxicities against various insects are well known. Nevertheless, there are rising evidences that neonicotinoids exert cytotoxic effects on different non-target organisms including mammals, fish, birds etc. Besides, depending on pesticide application, the exposed plants absorb some part of used neonicotinoids and their residues are detected in agricultural products worldwide. Thus, the continuous consumption of fruits and vegetables contaminated with neonicotinoids is a high risk factor for humans despite the low doses. Intestine epithelial cells are the first targets of the neonicotinoid cytotoxicity in humans because of its direct way of administration. The epithelial cells provide the barrier function of the intestinal system via specialized intercellular adhesion. The effects of imidacloprid on the intestine barrier function and inflammatory cytokines production are still unknown. In the present study, we exposed the human Caucasian colon adenocarcinoma (Caco-2) epithelial cells to low doses (0.10–0.75 µg/mL) of imidacloprid in order to assess the expression of tight and adherens junctions proteins, occludin and E-cadherin, and production of proinflammatory cytokine TNF α and iNOS. Imidacloprid induced dose-dependent decline in both occludin and E-cadherin levels. By contrast, TNF-α and iNOS contents were upregulated in imidacloprid-exposed Caco-2 cells. Decrease in tight and adherens junctions proteins indicates that the barrier function of intestine epithelial cells could be damaged by imidacloprid administration. In addition, TNF-α and iNOS upregulation indicates that imidacloprid is potent to activate proinflammatory response in enterocytes. Thus, imidacloprid can affect intestine barrier function through the increase of proinflammatory cytokine production and decrease in adhesiveness of enterocytes. The further assessment of the role of adhesion proteins and inflammatory cytokines in neonicotinoid pesticide cytotoxicity as it affects enterocyte barrier function is required to highlight the risk factor of use of neonicotinoids.

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“…As known, oxidative stress and inflammation are mutually dependent and connected [ 79 , 80 ]. The change of ROS also can reflect inflammatory conditions of the body [ 81 ]. Oxidative stress is a harmful process that can negatively affect several cellular structures, such as membranes, lipids, proteins, lipoproteins and DNA [ 82 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice

Cao

Peng

et al. 2023

BMC Microbiol

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Probiotics are defined as live microbial food elements that are beneficial to human health. Lacticaseibacillus casei T1 was considered to have potential as a bioactive ingredient in functional foods, which was isolated from kurut. Previous research by our group proved that L. casei T1 could prevent inflammatory responses caused by Helicobacter pylori. This study aimed to investigate whether treatment with L. casei T1 resulted in a suppressive effect on H. pylori-induced oxidative stress and inflammatory responses. The results showed that treatment with L. casei T1 could relieve H. pylori-induced overexpression of inflammatory cytokines in GES-1 cells. Experiments in animals suggested that taking long-term L. casei T1 could reduce oxidative stress and inflammatory cytokines and improve H. pylori-induced gastric mucosal damage. Furthermore, taking L. casei T1 could increase the relative abundance of beneficial intestinal bacterium (Lachnospiraceae and Odoribacter) of H. pylori-infected mice and help in maintaining the balance of intestinal microflora.Collectively, L. casei T1 had certain degrees of therapeutic effect against H. pylori. In the future, it combined with antibiotics for H. pylori eradication deserves further study.

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Imaging Biomarkers for Monitoring the Inflammatory Redox Landscape in the Brain

Cited by 9 publications

References 193 publications

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Comparison of monoamine oxidase and selected heavy metal levels in the blood and the workplace among e-waste sorting workers in Ubon Ratchathani Province, Thailand

Low doses of imidacloprid induce disruption of intercellular adhesion and initiate proinflammatory changes in Caco-2 cells

Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice

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