Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice

Abstract

Probiotics are defined as live microbial food elements that are beneficial to human health. Lacticaseibacillus casei T1 was considered to have potential as a bioactive ingredient in functional foods, which was isolated from kurut. Previous research by our group proved that L. casei T1 could prevent inflammatory responses caused by Helicobacter pylori. This study aimed to investigate whether treatment with L. casei T1 resulted in a suppressive effect on H. pylori-induced oxidative stress and inflammatory responses. The results showed that treatment with L. casei T1 could relieve H. pylori-induced overexpression of inflammatory cytokines in GES-1 cells. Experiments in animals suggested that taking long-term L. casei T1 could reduce oxidative stress and inflammatory cytokines and improve H. pylori-induced gastric mucosal damage. Furthermore, taking L. casei T1 could increase the relative abundance of beneficial intestinal bacterium (Lachnospiraceae and Odoribacter) of H. pylori-infected mice and help in maintaining the balance of intestinal microflora.Collectively, L. casei T1 had certain degrees of therapeutic effect against H. pylori. In the future, it combined with antibiotics for H. pylori eradication deserves further study.

Weissella cibaria Relieves Gut Inflammation Caused by Escherichia coli through Inflammation Modulation and Gut Microbiota Regulation

“…As intestinal pathogens have shown increased drug resistance, gastrointestinal discomfort and liver damage in humans and animals has been a hot topic. Probiotics not only provide resistance to gastrointestinal pathogens and improve immunity but also improve the gastrointestinal flora [30]. In this study, W. cibaria P-8 showed excellent inhibition against Pseudomonas aeruginosa Z1, Salmonella H9812, Acinetobacter baumannii C1, and MRSA, with the highest inhibitory activity against E. coli B2.…”

Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes

“…It has also been suggested that eradicating H. pylori from the body may be an important treatment for type 2 diabetes ( Shi et al., 2018 ; Shi and Chen, 2021 ). Firstly, H. pylori infection can lead to chronic inflammation of the stomach lining and abnormal secretion of gastric acid, which can affect the digestion of food and absorption of nutrients, which in turn affects metabolism and insulin secretion ( Pachathundikandi et al., 2023 ; Yu et al., 2023 ). Secondly, H. pylori infection can also affect the internal environment of the gastrointestinal tract and promote chronic low-grade inflammation, thereby inducing an inflammatory and immune response in the body, which further affects insulin sensitivity ( Azami et al., 2021 ).…”