Imaging behavioural complications of Parkinson’s disease

Valli, Mikaeel; Mihaescu, Alexander; Strafella, Antonio P.

doi:10.1007/s11682-017-9764-1

Cited by 19 publications

(16 citation statements)

References 96 publications

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“…The results showed a significant upregulation of TLR7 and TLR8, validating their involvement in the pathological process. It is well known that PD is characterized by a variety of behavioral deficits [43,44], resulting in a variety of symptoms concerning motor control, such as bradykinesia, rigidity, and tremor [45]. Anxiety symptoms are also very common in PD patients, and some authors state that anxiety in PD can be manifested even before the emergence of the first motor symptoms [46,47].…”

Section: Discussionmentioning

confidence: 99%

TLR7/8 in the Pathogenesis of Parkinson’s Disease

Campolo

Filippone

Biondo

et al. 2020

IJMS

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Neuroinflammation and autoimmune mechanisms have a key part in the pathogenesis of Parkinson’s disease (PD). Therefore, we evaluated the role of Toll-like receptors (TLRs) as a link between inflammation and autoimmunity in PD. An in vivo model of PD was performed by administration of 1-metil 4-fenil 1,2,3,6-tetraidro-piridina (MPTP) at the dose of 20 mg/kg every 2 h for a total administration of 80/kg, both in single Knock Out (KO) mice for TLR7, TLR 8, and TLR9 and in double KO mice for TLR 7/8-/-. All animals were compared with WT animals used as a control group. All animals were sacrificed after 7 days form the first administration of MPTP. The genetic absence of TLR 7 and 8 modified the PD pathway, increasing the immunoreactivity for TH and DAT compared to PD groups and decreasing microglia and astrocytes activation. Moreover, the deletion of TLR7 and TLR8 significantly reduced T-cell infiltration in the substantia nigra and lymph nodes, suggesting a reduction of T-cell activation. Therefore, our result highlights a possibility that an immunotherapy approach, by using a dual antagonist of TLR 7 and 8, could be considered as a possible target to develop new therapies for Parkinson diseases.

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Section: Discussionmentioning

confidence: 99%

TLR7/8 in the Pathogenesis of Parkinson’s Disease

Campolo

Filippone

Biondo

et al. 2020

IJMS

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“…In addition, several anatomical and functional MRI studies in patients with Parkinson's disease with ICDs have shown dysfunctions in limbic and cortico-subcortical circuits engaged in risk-taking, reward-learning, reducing punishment learning and outcome evaluation as well as cognitive control difficulties (Santangelo et al, 2017). These abnormalities mostly consist of dysfunctions of the ventral striatum and cortico-limbic areas as well as abnormal connectivity between the mesolimbic and meso-cortical regions (Cilia et al, 2010;Rao et al, 2010;van Eimeren et al, 2010;Voon et al, 2011b;Politis et al, 2013;Cerasa et al, 2014;Piray et al, 2014;Biundo et al, 2015;Carriere et al, 2015;Claassen et al, 2017;Tessitore et al, 2017;Valli et al, 2017;Petersen et al, 2018). However, most of these studies have enrolled pa-tients with Parkinson's disease with either various forms of ICDS or only pathological gambling (Steeves et al, 2009;Cilia et al, 2010Cilia et al, , 2011Rao et al, 2010;van Eimeren et al, 2010;O'Sullivan et al, 2011;Voon et al, 2011bVoon et al, , 2014Joutsa et al, 2012;Ray et al, 2012;Politis et al, 2013;Cerasa et al, 2014;Piray et al, 2014;Vriend et al, 2014;Biundo et al, 2015;Carriere et al, 2015;Tessitore et al, 2017;Petersen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Wait and you shall see: sexual delay discounting in hypersexual Parkinson’s disease

Girard

Obeso

Thobois

et al. 2018

Brain

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Patients with Parkinson's disease may develop impulse control disorders under dopaminergic treatments. Impulse control disorders include a wide spectrum of behaviours, such as hypersexuality, pathological gambling or compulsive shopping. Yet, the neural systems engaged in specific impulse control disorders remain poorly characterized. Here, using model-based functional MRI, we aimed to determine the brain systems involved during delay-discounting of erotic rewards in hypersexual patients with Parkinson's disease (PD+HS), patients with Parkinson's disease without hypersexuality (PD-HS) and controls. Patients with Parkinson's disease were evaluated ON and OFF levodopa (counterbalanced). Participants had to decide between two options: (i) wait for 1.5 s to briefly view an erotic image; or (ii) wait longer to see the erotic image for a longer period of time. At the time of decision-making, we investigated which brain regions were engaged with the subjective valuation of the delaye d erotic reward. At the time of the rewarded outcome, we searched for the brain regions responding more robustly after waiting longer to view the erotic image. PD+HS patients showed reduced discounting of erotic delayed rewards, compared to both patients with Parkinson's disease and controls, suggesting that they accepted waiting longer to view erotic images for a longer period of time. Thus, when using erotic stimuli that motivate PD+HS, these patients were less impulsive for th e immediate reward. At the brain system level, this effect was paralleled by the fact that PD+HS, as compared to controls and PD-HS, showed a negative correlation between subjective value of the delayed reward and activity of medial prefrontal cortex and ventral striatum. Consistent with the incentive salience hypothesis combining learned cue-reward associations with current relevant physiological state, dopaminergic treatment in PD+HS boosted excessive 'wanting' of rewards and heightened activity in the anterior medial prefrontal cortex and the posterior cingulate cortex, as reflected by higher correlation with subjective value of the option associated to the delayed reward when ON medication as compared to the OFF medication state. At the time of outcome, the anterior medial prefrontal/rostral anterior cingulate cortex showed an interaction between group (PD+HS versus PD-HS) and medication (ON versus OFF), suggesting that dopaminergic treatment boosted activity of this brain region in PD+HS when viewing erotic images after waiting for longer periods of time. Our findings point to reduced delay discounting of erotic rewards in PD+HS, both at the behavioural and brain system levels, and abnormal reinforcing effect of levodopa when PD+HS patients are confronted with erotic stimuli.

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“…According to the results of epidemiological studies, patients with PD are more prone to developing anxiety disorders and taking anxiolytic drugs before a diagnosis of PD [48]. The prevalence of anxiety disorders in patients with PD is up to 60%, however, anxiety remains unrecognized due to the similarity of symptoms with a neurological disease and comorbidity with depressive disorders -92% of patients with PD with diagnosed anxiety showed a depressive disorder, and 62% of depressed patients with PD -Anxiety Disorder [11,30,49,50]. Such overlap of symptoms is explained by a common neurobiological substrate: degeneration of the subcortical nuclei, dopamine, noradrenergic and serotonin pathways in the circuits, involving the fronto-basal ganglia, with a specific loss of dopaminergic and noradrenergic innervation in the locus coeruleus and limbic system of the brain [51].…”

Section: Anxiety and The Spectrum Of Anxiety Disordersmentioning

confidence: 99%

Affective and personality disorders in Parkinson's disease premotor phase. Pilot study.

Samushiya¹,

Ragimova²,

Смоленцева³

et al. 2020

Cogn. Remediat. J.

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Neuropsychiatric symptoms are one of the factors determining quality of life among Parkinson's disease patients, but often remain underestimated by clinicians, especially in early disease stage. Objective: to study the clinical features of affective disorders and comorbid personality traits in prodrome of Parkinson's disease (PD) and their effect on treatment adherence. Materials and methods: 29 patients with PD were studied with questionnaires (Toronto alexithymia scale (TAS); Minimult personal questionnaire; DSM-IV criteria (SCID-II); Hospital anxiety and depression scale (HADS); Hamilton Scale for the Assessment of Depression (HAM-D)), and clinical-psychopathological method with objective information collection, neurological examination and neuropsychological testing. Results: Among the patients with PD, personality premorbid features cluster C were most prominent (48% patients). Affective disorders in the prodromal period of PD are dysthymia (13.7%); cyclothymia (6.8%); recurrent depressive disorder (34.4%); and single depressive episode (44.8%). Affective disorders in PD are characterized by late onset, the prevalence of anxiety, asthenic-apathetic symptoms, as well as a high level of alexithymia and somatization. We found the relationship of personality traits and adherence to therapy: the least compliant are histrionic n = 3 (10.3%) and schizotypal n = 2 (6.9%) patients. A high prevalence of dissociative reactions (55%) was noted in response to a diagnosis of PD, which is similar to cancer patients.

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Imaging behavioural complications of Parkinson’s disease

Cited by 19 publications

References 96 publications

TLR7/8 in the Pathogenesis of Parkinson’s Disease

TLR7/8 in the Pathogenesis of Parkinson’s Disease

Wait and you shall see: sexual delay discounting in hypersexual Parkinson’s disease

Affective and personality disorders in Parkinson's disease premotor phase. Pilot study.

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