Imaging Based Methods of Liver Fibrosis Assessment in Viral Hepatitis: A Practical Approach

Khallafi, Hicham; Qureshi, Kamran

doi:10.1155/2015/809289

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…At present, serological indexes are the main clinical methods to assess hepatic fibrosis, although the accuracy needs to be improved[ 9 - 11 ]. The latest research has shown that ultrasound elastography can measure the hardness of liver tissue to determine the degree of hepatic fibrosis with features of non-invasiveness, simplicity, speed and repeatability[ 12 , 13 ]. However, its diagnostic accuracy is not high, and the accuracy of different studies are different[ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

Ningming

Cao

et al. 2018

WJG

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AIMTo investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity.METHODSA total of 338 chronic hepatitis B (CHB) patients were divided into a disease group (patients with hepatic fibrosis) and control group (subjects without hepatic fibrosis). The disease group was further divided into S1-S4 according to the degree of fibrosis. Independent risk factors for hepatic fibrosis were analyzed using multivariate logistic regression. The diagnostic values of hepatic fibrosis from different indicators were compared using receiver operating characteristic (ROC) curves. The combination of elastography and serological indexes was explored to assess the severity of hepatic fibrosis.RESULTSThe multivariate logistic regression analysis results revealed that shear wave velocity (SWV), hyaluronic acid (HA), type IV collagen (CIV) and aspartate aminotransferase-to-platelet ratio index (APRI) significantly affected the occurrence of hepatic fibrosis. The ROC curve revealed that the accuracy of the diagnosis of hepatic fibrosis for SWV and HA were 87.3% and 84.8%, respectively. The accuracy of SWV combined with HA was 88.9%. The multiple linear regression analysis revealed that SWV, aspartate aminotransferase (AST)/alanine aminotransferase (ALT), HA, CIV, APRI and fibrosis index based on the 4 factor (FIB-4) were screened as statistically significant independent factors. The established regression equation was: Fibrosis level = -4.046 + 1.024 × SWV + 1.170 × AST/ALT + 0.011 × HA + 0.020 × CIV + 0.719 × APRI + 0.379 × FIB-4.CONCLUSIONSWV combined with serological indexes can improve the accuracy of diagnosis for CHB hepatic fibrosis. Serum indexes can help diagnose the degree of hepatic fibrosis.

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Section: Introductionmentioning

confidence: 99%

Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

Ningming

Cao

et al. 2018

WJG

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Red cell distribution width-to-lymphocyte ratio

et al. 2020

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To evaluate the diagnostic power of red cell distribution width-to-lymphocyte ratio (RLR) for HBV-related liver cirrhosis via a retrospective cohort study. Seven hundred fifty healthy controls, 327 chronic hepatitis B (CHB) patients, and 410 patients with HBV-related liver cirrhosis (HBV-LC) were enrolled in this study. RLR, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), AST to platelet ratio index (APRI), and fibrosis index based on the 4 factors (FIB-4) were compared between the 3 groups. The predictive powers of RLR and RDW for HBV-related liver cirrhosis and patient prognosis were evaluated using AUROC. Patients with HBV-related liver cirrhosis had higher RLR, FIB-4, NLR, RDW, APRI, and lower LMR compared with the control and CHB groups. RLR in the HBV-LC group was significantly higher than both CHB and control groups (both P < .05). While RLR in the CHB group was also higher than the control group, the difference was not statistically significant (P > .05). The AUROC of RLR for predicting HBV-related liver cirrhosis was 0.87, and was superior to RDW (0.81), FIB-4 (0.79), and APRI (0.60). With an optimized cut-off value (10.87), RLR had the highest sensitivity (0.88) and specificity (0.72), and was superior to RDW (0.86, 0.64), FIB-4 (0.80, 0.65), and APRI (0.85, 0.48) as a biomarker. For all 3 groups, RLR was negatively correlated (all P < .05) with serum platelet (PLT) and was positively correlated (all P < .05) with FIB-4 and APRI. There was no significant statistical difference in RLR for patients in HBV-LC group who had different prognosis (P > .05). The RLR, a routinely available, inexpensive, and easily calculated measure, can be used as a predictor of HBV-related liver cirrhosis, but not as a predictor of prognosis for patients with liver cirrhosis. Use of RLR may reduce the need for frequent liver biopsies in CHB patients.

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Imaging Based Methods of Liver Fibrosis Assessment in Viral Hepatitis: A Practical Approach

Cited by 2 publications

References 67 publications

Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

Red cell distribution width-to-lymphocyte ratio

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