Imaging and Clinical Features of COVID-19 Breakthrough Infections: A                     Multicenter Study

Lee, Jong Eun; Hwang, Minhee; Kim, Yun‐Hyeon; Chung, Myung Jin; Sim, Byeong Hak; Chae, Kum Ju; Yoo, Jin Young; Jeong, Yohan

doi:10.1148/radiol.213072

Cited by 57 publications

(86 citation statements)

References 26 publications

(14 reference statements)

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“…Compared with previous studies on the imaging performance of patients with immune breakthrough in Table 3, CT scores in the unvaccinated group and fully vaccinated group were similar in Omicron and other type variant. In partially vaccinated group, the proportion of patients with negative CT performance in this study (54%) was larger than that in other type variant (30%), the proportion of patients with CT score 1 in Omicron variant (32%) was less than that in other type (53%) (P=0.005), and the proportion of patients with CT score 2 showed no signi cant different [14](Figure 3). [14].…”

Section: Proportions Of Chest Ct Scores By Vaccination Status and Vir...mentioning

confidence: 54%

“…In partially vaccinated group, the proportion of patients with negative CT performance in this study (54%) was larger than that in other type variant (30%), the proportion of patients with CT score 1 in Omicron variant (32%) was less than that in other type (53%) (P=0.005), and the proportion of patients with CT score 2 showed no signi cant different [14](Figure 3). [14]. Each subscript indicates a subset of the virus type categories, and at the 0.05 level, the column proportions of these categories do not differ signi cantly from each other.…”

Section: Proportions Of Chest Ct Scores By Vaccination Status and Vir...mentioning

confidence: 54%

“…To compare the imaging ndings and clinical characteristics of the immune breakthrough, we compared them with a published multicenter research that included 761 patients from July to August 2021 [14]. But the study did not mention the type of SARS-CoV-2.…”

Section: Clinical and Laboratory Datamentioning

confidence: 99%

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The imaging and clinical characteristics of patients with immune breakthrough Omicron-variant infected patients, Tianjin China: Is the vaccine effective?

Chang

Wang

et al. 2022

Preprint

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Background The protective effect of the inactivated vaccine against the omicron variant of COVID-19 is unclear. The purpose of this study was to investigate the protective effect of different vaccination status on omicron infection. Methods In this retrospective study, we analyzed patients over 14 years old, and were diagnosed with immune breakthrough Omicron-variant infection between December 2021 and February 2022 in Tianjin, China, as well as data from several previous study infected by other types of SARS-CoV-2. The data were subdivided into three groups: patients with fully, partially and unvaccine. Differences of clinical and imaging characteristics were compared based on the different vaccination status using Pearson Chi-square test, Fisher's accuracy test and non-parametric test. All of the data were also compared with other types of SARS-CoV-2. Logistic regression and mediation effect analysis were used to assess the association between vaccination status and pneumonia progression during hospitalization. Results Among the 314 cases of immune breakthrough Omicron-variant infected patients, 21(7%) patients were unvaccinated, 134 (43%) were partially vaccinated, and 159 (50%) were full vaccinated. Among fully vaccinated patients, the proportion of patients with positive CT findings (32%) and CT score 2 (6%) was significantly lower than that of partially vaccinated (46%, 14%) and unvaccinated patients (67%, 19%) (P < 0.05). CT score by vaccination status are similar between Omicron and other types, only partially vaccinated group of Omicron infected patients show lower CT score than other types infected patients (P = 0.005). Increased age and lower IgG levels were associated with the risk of disease progression. IgG level had a complete mediating effect between vaccination status/ days after vaccination and disease progression. Conclusion The inactivated vaccine provided similar protection against Omicron infection of SARS-CoV-2, compared to the patients who received other types vaccines. Compared with partially vaccinated and unvaccinated patients, fully vaccinated patients had a higher CT negative rate and a lower rate of severe pneumonia. Vaccination status and days after vaccination affect disease progression through IgG levels.

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Section: Proportions Of Chest Ct Scores By Vaccination Status and Vir...mentioning

confidence: 54%

Section: Proportions Of Chest Ct Scores By Vaccination Status and Vir...mentioning

confidence: 54%

See 1 more Smart Citation

The imaging and clinical characteristics of patients with immune breakthrough Omicron-variant infected patients, Tianjin China: Is the vaccine effective?

Chang

Wang

et al. 2022

Preprint

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“…We read with great interest the article by Dr. Lee and colleagues published online in Radiology on February 1, 2022 ( 1 ). In their large cohort of 716 hospitalized patients with coronavirus disease (COVID-19), vaccinated patients exhibited fewer chest computed tomography findings of COVID- 19 pneumonia than unvaccinated patients.…”

Section: Editormentioning

confidence: 99%

“…In their large cohort of 716 hospitalized patients with coronavirus disease (COVID-19), vaccinated patients exhibited fewer chest computed tomography findings of COVID- 19 pneumonia than unvaccinated patients. Additionally, the need for ventilatory support and the frequency of intensive care unit admission were significantly lower in the vaccinated group than in the unvaccinated group ( 1 ).…”

Section: Editormentioning

confidence: 99%

Vaccination and Reduced Severity of COVID-19 Pneumonia Viewed at Chest Radiography

Borghesi

Maroldi

2022

Radiology

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Chest CT features of COVID-19 in vaccinated versus unvaccinated patients: use of CT severity score and outcome analysis

Masci,

Izzo,

Bonito

et al. 2023

Radiol med

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Objectives To evaluate the impact of vaccination on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and moreover on coronavirus disease 2019 (COVID-19) pneumonia, by assessing the extent of lung disease using the CT severity score (CTSS). Methods Between September 2021 and February 2022, SARS-CoV-2 positive patients who underwent chest CT were retrospectively enrolled. Anamnestic and clinical data, including vaccination status, were obtained. All CT scans were evaluated by two readers using the CTSS, based on a 25-point scale. Univariate and multivariate logistic regression analyses were performed to evaluate the associations between CTSS and clinical or demographic variables. An outcome analysis was used to differentiate clinical outcome between vaccinated and unvaccinated patients. Results Of the 1040 patients (537 males, 503 females; median age 58 years), 678 (65.2%) were vaccinated and 362 (34.8%) unvaccinated. Vaccinated patients showed significantly lower CTSS compared to unvaccinated patients (p < 0.001), also when patients without lung involvement (CTSS = 0) were excluded (p < 0.001). Older age, male gender and lower number of doses administered were associated with higher CTSS, however, in the multivariate analysis, vaccination status resulted to be the variable with the strongest association with CTSS. Clinical outcomes were significantly worse in unvaccinated patients, including higher number of ICU admissions and higher mortality rates. Conclusions Lung involvement during COVID-19 was significantly less severe in vaccinated patients compared with unvaccinated patients, who also showed worse clinical outcomes. Vaccination status was the strongest variable associated to the severity of COVID-related, more than age, gender, and number of doses administered.

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Imaging and Clinical Features of COVID-19 Breakthrough Infections: A Multicenter Study

Cited by 57 publications

References 26 publications

The imaging and clinical characteristics of patients with immune breakthrough Omicron-variant infected patients, Tianjin China: Is the vaccine effective?

The imaging and clinical characteristics of patients with immune breakthrough Omicron-variant infected patients, Tianjin China: Is the vaccine effective?

Vaccination and Reduced Severity of COVID-19 Pneumonia Viewed at Chest Radiography

Chest CT features of COVID-19 in vaccinated versus unvaccinated patients: use of CT severity score and outcome analysis

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