Image Quality and Potential Dose Reduction Using Advanced Modeled Iterative Reconstruction (Admire) in Abdominal Ct - A Review

Kataria, Bharti; Althén, Jonas Nilsson; Smedby, Örjan; Persson, Anders; Sökjer, H.; Sandborg, Michael

doi:10.1093/rpd/ncab020

Cited by 18 publications

(12 citation statements)

References 19 publications

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“…However, this level has shown benefits in abdominal imaging. 27,28 Finally, we did not compare PCD-CT with other CT scanners of different vendors.…”

Section: Discussionmentioning

confidence: 99%

Photon-Counting Detector CT With Quantum Iterative Reconstruction

et al. 2022

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ObjectivesTo assess image noise, diagnostic performance, and potential for radiation dose reduction of photon-counting detector (PCD) computed tomography (CT) with quantum iterative reconstruction (QIR) in the detection of hypoattenuating and hyperattenuating focal liver lesions compared with energy-integrating detector (EID) CT.Materials and MethodsA medium-sized anthropomorphic abdominal phantom with liver parenchyma and lesions (diameter, 5–10 mm; hypoattenuating and hyperattenuating from −30 HU to +90 HU at 120 kVp) was used. The phantom was imaged on (a) a third-generation dual-source EID-CT (SOMATOM Force, Siemens Healthineers) in the dual-energy mode at 100 and 150 kVp with tin filtration and (b) a clinical dual-source PCD-CT at 120 kVp (NAEOTOM Alpha, Siemens). Scans were repeated 10 times for each of 3 different radiation doses of 5, 2.5, and 1.25 mGy. Datasets were reconstructed as virtual monoenergetic images (VMIs) at 60 keV for both scanners and as linear-blended images (LBIs) for EID-CT. For PCD-CT, VMIs were reconstructed with different strength levels of QIR (QIR 1–4) and without QIR (QIR-off). For EID-CT, VMIs and LBIs were reconstructed using advanced modeled iterative reconstruction at a strength level of 3. Noise power spectrum was measured to compare image noise magnitude and texture. A channelized Hotelling model observer was used to assess diagnostic accuracy for lesion detection. The potential for radiation dose reduction using PCD-CT was estimated for the QIR strength level with the highest area under the curve compared with EID-CT for each radiation dose.ResultsImage noise decreased with increasing QIR level at all radiation doses. Using QIR-4, noise reduction was 41%, 45%, and 59% compared with EID-CT VMIs and 12%, 18%, and 33% compared with EID-CT LBIs at 5, 2.5, and 1.25 mGy, respectively. The peak spatial frequency shifted slightly to lower frequencies at higher QIR levels. Lesion detection accuracy increased at higher QIR levels and was higher for PCD-CT compared with EID-CT VMIs. The improvement in detection with PCD-CT was strongest at the lowest radiation dose, with an area under the receiver operating curve of 0.917 for QIR-4 versus 0.677 for EID-CT VMIs for hyperattenuating lesions, and 0.900 for QIR-4 versus 0.726 for EID-CT VMIs for hypoattenuating lesions. Compared with EID-CT LBIs, detection was higher for QIR 1–4 at 2.5 mGy and for QIR 2–4 at 1.25 mGy (eg, 0.900 for QIR-4 compared with 0.854 for EID-CT LBIs at 1.25 mGy). Radiation dose reduction potential of PCD-CT with QIR-4 was 54% at 5 mGy compared with VMIs and 39% at 2.5 mGy compared with LBIs.ConclusionsCompared with EID-CT, PCD-CT with QIR substantially improved focal liver lesion detection, especially at low radiation dose. This enables substantial radiation dose reduction while maintaining diagnostic accuracy.

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“…However, this level has shown benefits in abdominal imaging. 27,28 Finally, we did not compare PCD-CT with other CT scanners of different vendors.…”

Section: Discussionmentioning

confidence: 99%

Photon-Counting Detector CT With Quantum Iterative Reconstruction

et al. 2022

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“…Many studies have demonstrated that the MBIR algorithms can substantially improve CTP image quality compared with the filtered back-projection (FBP) (Kataria et al 2021). Meanwhile, there are some disadvantages in them.…”

Section: Mbir Methodsmentioning

confidence: 99%

Basis and current state of computed tomography perfusion imaging: a review

Zeng¹,

Zeng²,

Sui³

et al. 2022

Phys. Med. Biol.

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Computed tomography perfusion (CTP) is a functional imaging that allows for providing capillary-level hemodynamics information of the desired tissue in clinics. In this paper, we aim to offer insight into CTP imaging which covers the basics and current state of CTP imaging, then summarize the technical applications in the CTP imaging as well as the future technological potential. At first, we focus on the fundamentals of CTP imaging including systematically summarized CTP image acquisition and hemodynamic parameter map estimation techniques. A short assessment is presented to outline the clinical applications with CTP imaging, and then a review of radiation dose effect of the CTP imaging on the different applications is presented. We present a categorized methodology review on known and potential solvable challenges of radiation dose reduction in CTP imaging. To evaluate the quality of CTP images, we list various standardized performance metrics. Moreover, we present a review on the determination of infarct and penumbra. Finally, we reveal the popularity and future trend of CTP imaging.

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“…The increasing awareness of risks associated with radiation exposure triggered a variety of dose-reduction techniques, such as tube current or tube voltage modulation, automatic exposure control, and low-kilovolt scanning [26], where a dose reduction between 10% and 30% is possible, depending on examination type. Compared to the real-time analytical reconstruction method, filtered back projection (FBP) [27], which has reached its limitation and does not allow for further dose reductions, vendor-specific iterative reconstruction algorithms were introduced, which allow further dose reductions [28,29].…”

Section: Gan Manufacture and Ganificationmentioning

confidence: 99%

GaN Heterostructures as Innovative X-ray Imaging Sensors—Change of Paradigm

et al. 2022

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Direct conversion of X-ray irradiation using a semiconductor material is an emerging technology in medical and material sciences. Existing technologies face problems, such as sensitivity or resilience. Here, we describe a novel class of X-ray sensors based on GaN thin film and GaN/AlGaN high-electron-mobility transistors (HEMTs), a promising enabling technology in the modern world of GaN devices for high power, high temperature, high frequency, optoelectronic, and military/space applications. The GaN/AlGaN HEMT-based X-ray sensors offer superior performance, as evidenced by higher sensitivity due to intensification of electrons in the two-dimensional electron gas (2DEG), by ionizing radiation. This increase in detector sensitivity, by a factor of 104 compared to GaN thin film, now offers the opportunity to reduce health risks associated with the steady increase in CT scans in today’s medicine, and the associated increase in exposure to harmful ionizing radiation, by introducing GaN/AlGaN sensors into X-ray imaging devices, for the benefit of the patient.

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Image Quality and Potential Dose Reduction Using Advanced Modeled Iterative Reconstruction (Admire) in Abdominal Ct - A Review

Cited by 18 publications

References 19 publications

Photon-Counting Detector CT With Quantum Iterative Reconstruction

Photon-Counting Detector CT With Quantum Iterative Reconstruction

Basis and current state of computed tomography perfusion imaging: a review

GaN Heterostructures as Innovative X-ray Imaging Sensors—Change of Paradigm

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