Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles

Zhao, Changhong; Song, Xuebin; Jin, Weiguang; Wu, Fan; Zhang, Qicheng; Zhang, Ming; Zhou, Ninglin; Shen, Jian

doi:10.1016/j.aca.2018.12.045

Cited by 46 publications

(21 citation statements)

References 36 publications

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“…Even though they are not considered strictly as polymeric nanoparticles, polymer-modified superparamagnetic iron oxide NPs (also called SPIONPs or Fe 3 O 4 NPs) are remarkable contrast agents which are used in cancer imaging, thus deserving a special mention in this section [ 111 , 112 , 113 ]. Among their features, their capability to be surface-modified, in order to add polymeric agents that improve their imaging properties, as well as granting active targeting features, is a very powerful tool used in current investigations on developing new imaging agents [ 114 , 115 , 116 , 117 ].…”

Section: Polymeric Nanoparticles In Cancer Diagnosis and Imagingmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

et al. 2020

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The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.

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Section: Polymeric Nanoparticles In Cancer Diagnosis and Imagingmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

et al. 2020

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“…Zhao et al used Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) as the carrier to load DOX to realize combined chemotherapy/PTT. A carbon layer was applied to cover the magnetite to improve its stability and photothermal conversion efficiency [ 108 ]. To improve the targeting of Fe 3 O 4 /carbon/DOX nanoparticles (Fe 3 O 4 /C/DOX NPs), the aptamers (sgc8) were modified on the surface of Fe 3 O 4 /C/DOX NPs.…”

Section: Aptamer-bound Nanomaterials Used In Different Cancer Therapiesmentioning

confidence: 99%

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

et al. 2021

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Cancer is still a major disease that threatens human life. Although traditional cancer treatment methods are widely used, they still have many disadvantages. Aptamers, owing to their small size, low toxicity, good specificity, and excellent biocompatibility, have been widely applied in biomedical areas. Therefore, the combination of nanomaterials with aptamers offers a new method for cancer treatment. First, we briefly introduce the situation of cancer treatment and aptamers. Then, we discuss the application of aptamers in breast cancer treatment, lung cancer treatment, and other cancer treatment methods. Finally, perspectives on challenges and future applications of aptamers in cancer therapy are discussed.

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“…The results revealed that PEG- b -(PR- r -ICG), when irradiated with 808 nm NIR, produced maximum thermal (T max ) heat of 51.9–53.1 °C, which completely eliminated the tumor. Zhao et al [ 105 ] used an sgc8c aptamer-functionalized Fe 3 O 4 @carbon@doxorubicin NP (Apt-Fe 3 O 4 @C@DOX), where the sgc8c aptamer served as an active tumor-targeting ligand by endocytosis, Fe 3 O 4 allowed for MR imaging and PTT with a T max of 55.6 °C for the optimal delivery of DOX, as a synergetic enabled nanotheranostic for monitoring of the therapeutic responses of tumor [ 106 ]. Moreover, work by Gong and colleagues [ 107 ] developed a macrophage-cancer cell hybrid membrane-coated doxorubicin (Dox)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticle (DPLGA@[RAW-4T1] NPs) for targeting and treating breast cancer-derived lung metastases.…”

Section: Targeting Strategiesmentioning

confidence: 99%

The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers

et al. 2021

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The synthesis and engineering of nanomaterials offer more robust systems for the treatment of cancer, with technologies that combine therapy with imaging diagnostic tools in the so-called nanotheranostics. Among the most studied systems, there are quantum dots, liposomes, polymeric nanoparticles, inorganic nanoparticles, magnetic nanoparticles, dendrimers, and gold nanoparticles. Most of the advantages of nanomaterials over the classic anticancer therapies come from their optimal size, which prevents the elimination by the kidneys and enhances their permeation in the tumor due to the abnormal blood vessels present in cancer tissues. Furthermore, the drug delivery and the contrast efficiency for imaging are enhanced, especially due to the increased surface area and the selective accumulation in the desired tissues. This property leads to the reduced drug dose necessary to exert the desired effect and for a longer action within the tumor. Finally, they are made so that there is no degradation into toxic byproducts and have a lower immune response triggering. In this article, we intend to review and discuss the state-of-the-art regarding the use of nanomaterials as therapeutic and diagnostic tools for lung, breast, and prostate cancer, as they are among the most prevalent worldwide.

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Image-guided cancer therapy using aptamer-functionalized cross-linked magnetic-responsive Fe3O4@carbon nanoparticles

Cited by 46 publications

References 36 publications

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

The State of the Art of Theranostic Nanomaterials for Lung, Breast, and Prostate Cancers

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