Image-Based, Fiber Guiding Scaffolds: A Platform for Regenerating Tissue Interfaces

Park, Chan Ho; Ríos, Héctor F.; Taut, Andrei D.; Padial‐Molina, Miguel; Flanagan, Colleen L.; Pilipchuk, Sophia P.; Hollister, Scott J.; Giannobile, William V.

doi:10.1089/ten.tec.2013.0619

Cited by 100 publications

(103 citation statements)

References 42 publications

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“…Dentin blocks wrapped in the PDLSC sheet showed the potential to develop well-organized PDL tissues with perpendicular and oblique orientation of collagen fibers on the dentin surfaces [23]. In another study, PDLSC transplanted into fenestration defects with fiber-guiding scaffolds produced by the rapid prototyping technique induced the regeneration of PDL-like tissues that showed angulations similar to healthy and mature ligamentous tissues [24]. Moreover, injection of autologous PDLSC with bone grafting materials into the intrabony defects of deep periodontal pockets in 3 periodontitis patients significantly improved the value of clinical index including probing depth, gingival recession, and attachment level, and attachment gain, which persisted for up to 72 months [25].…”

Section: Potential Of Pdlsc To Regenerate Periodontal Structuresmentioning

confidence: 99%

Periodontal Ligament Stem Cells in Regenerative Dentistry for Periodontal Tissues

Tomokiyo¹

2016

JSRT

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The ideal periodontal treatment is regenerating functional periodontal tissues destroyed by severe periodontitis. The tissue engineering triad includes stem cells, biological signals, and cell-seeded scaffold that are considered to be essential for tissue regeneration. Periodontal ligament (PDL) tissue contains a stem cell population, periodontal ligament stem cells (PDLSC), that is derived the neural crest tissue. PDLSC demonstrate high proliferative capacity and multipotency that make them a highly promising stem cell population for use in the regeneration of damaged periodontal tissues. Here, we review the current understanding of the features and functions of PDLSC. Keywords: Periodontal ligament; Regeneration; Stem cells; Periodontal tissues;Biological signals of the periodontium and around 50% of adults suffer from its moderate and severe generalized form [2] Severe generalized form of periodontitis induces the destruction of PDL tissues including the loss of collagen fiber attachment between alveolar bones to the cementum surface and the progression of alveolar bone resorption, which is a principal cause for tooth loss [3]. Therefore, the regeneration of PDL tissues damaged by advanced periodontitis would be important to maintain healthy teeth for a lifetime. Stem cells are self-sustaining by replicating themselves and show the potential to differentiate into various cell types. Many researchers believe that these features of stem cells may offer benefits in the field of cell-based regenerative therapy. PDL stem cells (PDLSC) are a kind of dental stem cells identified in PDL tissues and originate from the neural crest tissue. They also have the potential to differentiate into a variety of PDL cells including fibroblasts, osteoblasts, cementoblasts, enthothelial cells, neural cells [4,5]. The aim of this review is to summarize the key topics of PDLSC including their properties, characteristics, current research, and future potential for PDLSC-based regenerative periodontal therapies. Characteristic of periodontal ligament stem cellsThe stem/progenitor cell populations have been revealed to be derived from endosteal spaces that are enriched immmature cells [6]. These cells have the potential to differentiate into multipule PDL cell including fibroblasts, osteoblasts, and cementoblasts that are principal for maintainance and homeostasis of PDL tissues [7]. Seo et al. [8] first isolated PDLSC from the PDL tissue of extracted human third molar teeth [8]. Many types of MSCrelated cell surface markers such as CD10, CD13, CD26, CD29, CD44, CD71, CD73, CD90, CD105, CD106, CD146, CD166, CD349, STRO-1, STRO-3, and TNAP/MSCA-1 have been identified in PDLSC [9]. PDLSC formed mineralized nodules with the increase of bone-related gene expression when they were cultured in osteogenic medium [8]. Additionally, PDLSC injected into calvarial defect model mice demonstrated the new bone formation within the defects [10], suggesting that PDLSC have the capacity to differentiate into osteoblasts. PDLSC was also induced...

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Section: Potential Of Pdlsc To Regenerate Periodontal Structuresmentioning

confidence: 99%

Periodontal Ligament Stem Cells in Regenerative Dentistry for Periodontal Tissues

Tomokiyo¹

2016

JSRT

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“…24–31,126 Ivanovski and colleagues 25 provided a comprehensive perspective regarding the association between scaffolds with cells and/or GFs to engineer 3D structures capable of influencing a spatiotemporal wound-healing cascade to encourage predictable regeneration. Notably, the ability to form highly complex 3D multiphasic scaffolds with tissue compartmentalization properties to encourage: (i) bone and periodontal attachment formation and integration, (ii) promotion of cementum formation onto the root surface, and (iii) the establishment of suitably oriented PDL fibers that attach to regenerated bone and cementum, have significantly advanced the field of periodontal tissue engineering.…”

Section: Advanced Biomaterials For Periodontal Regenerationmentioning

confidence: 99%

“…The work reported in the literature has not only included antimicrobials and inorganic particles (e.g., calcium phosphates), but also biomolecules (e.g., growth factors), in the fabrication of membranes with therapeutic functions. 21,23 More recently, the combination of known materials and biomolecules with advanced technologies 24–31 , particularly 3D printing, have permitted translation of the first patient-specific scaffold modified with platelet-derived growth factor (rhPDGF-BB) for treating large periodontal defects. 26 …”

Section: Introductionmentioning

confidence: 99%

Advanced Scaffolds for Dental Pulp and Periodontal Regeneration

Bottino

Pankajakshan

Nör

2017

Dental Clinics of North America

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“…PDLSC sheet combined with a dentin block scaffold has also been shown to develop cementum-like mineralized tissues and PDL-like collagen fibers [68]. In another study, fenestration defects were surgically created in nude rats, and then architectural scaffolds were designed to correspond with the defects containing perpendicular and oblique orientation of the PDL [69]. These constructs were implanted into the defects and resulted in the generation of new bone, cementum, and specific oriented fibrous bundles that were attached and anchored in a manner similar to mature, healthy periodontal complexes.…”

Section: Periodontal Ligament Stem Cellsmentioning

confidence: 99%