Image-based computational simulation of sub-endothelial LDL accumulation in a human right coronary artery

Nouri, Mohammad; Jalali, Farhang; Karimi, Gholamreza; Zarrabi, Khalil

doi:10.1016/j.compbiomed.2015.04.013

Cited by 16 publications

(11 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Newtonian and non-Newtonian blood models are also compared in Thanapong Chaicana et al, [12] paper, where there are almost similar values for WSS in both blood models, representing huge similarities in WSS values although having different blood models. Based on the [11,12,8,18,19,21] papers, we can find a mutual agreement of the authors regarding hemodynamic parameters related significantly to the physiological blood flow. Details of the studies can be observed in Table 1 and Table 2.…”

Section: Principle Outcome: Comparison Of Methods Equations and Finmentioning

confidence: 74%

“…CFD is a tool that has been used for decades in simulation and fluid flow processes. Many researchers consider this method while underwent experimental and simulation investigation for their research as it is time-consuming and low in cost [8,11,12,[18][19][20]. This CFD method not only limited to the selective field such as the mechanical and fluid field but also brings a great contribution to medical fields.…”

Section: Methodology 21 Data Extraction and Analysismentioning

confidence: 99%

“…The results show that the flow velocity increased significantly due to the resultant lumen stenosis with WSS contour values ranged from 0 Pa to 3.50 Pa observed in both Newtonian and non-Newtonian fluid models. Mohammad Nouri et al, [8] in his research suggested that low-density lipoproteins (LDL) in the vessel walls as the initiator of atherosclerosis and CAD problems. Simulated Non-Newtonian blood flow through normal and hypertensive conditions was reconstructed from CT images.…”

Section: Materials and Specificationsmentioning

confidence: 99%

“…To understand the effect of the plaque distribution whether in physiological blood flow or hemodynamically, we refer to the computational fluid dynamics (CFD) methods that have been used widely for the research of CVDs. CFD is a feasible method that has been used for ages [1,5,[8][9][10][11][12] in determining fluid flow and 3D model of coronary arteries. Besides studying about factors stimulating CAD such as bifurcations of coronary artery angles [5,9,11,12], image segmentation [8] and using finite element simulations [10], CFD can simulate an accurate flow of coronary arteries based on any parameter given.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Rosli¹,

Adib²,

Hasni³

et al. 2020

ARFMTS

View full text Add to dashboard Cite

Section: Principle Outcome: Comparison Of Methods Equations and Finmentioning

confidence: 74%

Section: Methodology 21 Data Extraction and Analysismentioning

confidence: 99%

Section: Materials and Specificationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Rosli¹,

Adib²,

Hasni³

et al. 2020

ARFMTS

View full text Add to dashboard Cite

“…One condition that is associated with atherosclerosis is the accumulation of LDL-c in the intima-media layer of the artery, together with endothelial dysfunction. The latter, in turn, may result in structural modifications with the accumulation of LDL-c in the arterial intima and, consequently, lead to the formation of atheroma plaques [ 59 , 60 ]. Thereafter, this accumulation of LDL-c may be oxidized and lead to the formation of oxLDL, which results in an increase of adhesion molecules and the secretion of proinflammatory cytokines by endothelial cells with consequent infiltration of monocytes and macrophages within the intima.…”

Section: Common Brazilian Cerrado Campomanesia mentioning

confidence: 99%

Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions

et al. 2018

View full text Add to dashboard Cite

Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome.

show abstract

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

Vuong,

Bartolf‐Kopp,

Andelovic

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality, elevated healthcare costs, diminished productivity, and reduced quality of life for individuals and their communities. This is exacerbated by the limited understanding of its underlying causes and limitations in current therapeutic interventions, highlighting the need for sophisticated models of atherosclerosis. This review critically evaluates the computational and biological models of atherosclerosis, focusing on the study of hemodynamics in atherosclerotic coronary arteries. Computational models account for the geometrical complexities and hemodynamics of the blood vessels and stenoses, but they fail to capture the complex biological processes involved in atherosclerosis. Different in vitro and in vivo biological models can capture aspects of the biological complexity of healthy and stenosed vessels, but rarely mimic the human anatomy and physiological hemodynamics, and require significantly more time, cost, and resources. Therefore, emerging strategies are examined that integrate computational and biological models, and the potential of advances in imaging, biofabrication, and machine learning is explored in developing more effective models of atherosclerosis.

show abstract

Image-based computational simulation of sub-endothelial LDL accumulation in a human right coronary artery

Cited by 16 publications

References 48 publications

Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

Contact Info

Product

Resources

About