Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Rosli, Nur Afikah Khairi; Adib, Mohd Azrul Hisham Mohd; Hasni, Nur Hazreen Mohd; Abdullah, M.J.

doi:10.37934/arfmts.74.1.1934

Cited by 5 publications

(3 citation statements)

References 24 publications

(48 reference statements)

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“…Hemodynamics refers to the physical study of flowing blood and all the solid structures (such as arteries) through which it flows. It plays an interactive role in physiological and pathological conditions, especially in angiogenesis (Wiewiora et al, 2019) and cardiovascular disease (Rosli et al, 2020). The cardiovascular system is a complex, regulated physiological system critically involved in essential life-support functions that maintain metabolic homeostasis.…”

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confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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Angiogenesis and hemodynamic instability created by the irregular blood vessels causes hypoperfusion and angiogenesis‐mediated diseases. Therefore, therapies focusing on controlling angiogenesis will be a valuable approach to treat a broad spectrum of diseases. In this study, we explored the anti‐angiogenic potential of berberine (BBR) and also analyzed blood flow hemodynamics using zebrafish embryos. Zebrafish embryos treated with BBR (0.01–0.75 mM) at various doses at 1 hour post‐fertilization (hpf) developed a variety of phenotypic variations including aberrant blood vessels, tail bending, edema, and hemorrhage. Survival rates were much lower at higher dosages, and hatching rates were almost 99%, whereas control group appeared normal. Heart rate is an essential measure that has a strong association with hemodynamics. We used ImageJ software to study the heart rate of embryos treated with BBR, preceded by video processing. The resultant graph shows a significant decrease in heart rate of embryos treated with BBR in dose‐dependent manner. Also, RBC staining using o‐Dianisidine confirms the anti‐angiogenic potential of BBR by indicating the decrease in the intersegmental vessels at 0.5 and 0.75 mM treated embryos. Further, the gene expression study determined that the transcripts (vegf, vegfr2, nrp1a, hif‐1α, nos2a, nos2b, cox‐2a, and cox‐2b) measured were found to be downregulated by BBR at 0.5 mM concentration, from which we conclude that enos/vegf signaling could play an important role in modulating angiogenesis. Our data imply that BBR may be an effective compound for suppressing angiogenesis in vivo, which might be helpful in the treatment of vascular disorders like cancer and diabetic retinopathy in future.

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confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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“…Using computational fluid dynamics (CFD) simulation to achieve better insight of hemodynamic parameters have been reported to be valuable predictors for aneurysmal rupture [10]. Hemodynamic studied the blood flow and presented as the principles that control the distribution of blood flow and blood pressure in the vascular system [12,24]. It is important to consider hemodynamic in studying flow characteristic on aneurysm as hemodynamic factors, including wall shear stress (WSS) is known as a risk indicator for aneurysm development and rupture [11] Other than that, the geometric structure and mechanical properties of the remodeled vessel also play a major role in disease process including aneurysm [12].…”

Section: Introductionmentioning

confidence: 99%

Flow Characteristics on Carotid Artery Bifurcation of Different Aneurysmal Morphology

Saufi

Roseman²,

Taib³

et al. 2023

CFDL

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Aneurysm is a vascular disorder characterized by abnormal focal dilation of an artery which is considered as a serious and potentially life-threatening condition. An estimated 2%–5% of the general population is affected by intracranial aneurysms. Through computational fluid dynamic (CFD) investigation, this study aims to learn the flow characteristic on aneurysm afflicted common carotid artery (CCA). This study focused on the velocity, wall shear stress (WSS) and sensitivity of blood viscosity of the CCA flow. CFD method was done to 3 simplified model of CCA which were normal, saccular aneurysm, fusiform aneurysm CCA model. The simulation was done with different blood viscosity model which were Newtonian and non-Newtonian. The high velocity area of blood flow has corresponding effect to the increase of the WSS distribution to the wall of the geometry. The results also showed at certain value of low velocity area, WSS distribution for different blood viscosity model was deviated significantly.

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“…In some cases, the aneurysm does not rupture but causes serious health problems such as vomiting, nerve paralysis, and headache because of compression of surrounding brain tissue and nerves [15]. Hemodynamic conditions can influence the growth and rupture of an intracranial aneurysm [19,20]. The factor influencing aneurysm growth at this stage still requires extensive research to fully understand the process [17,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Temperature Variation with Hemodynamic Effect Simulation on Wall Shear Stress in Fusiform Cerebral Aneurysm

Ahmad Faiz Mat Zin,

Ishkrizat Taib,

Muhammad Hanafi Asril Rajo Mantari

et al. 2022

ARFMTS

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A cerebral aneurysm is the dilation of an arterial wall and mostly occurs at the weak point in the arterial circulation in the brain. Approximately 85% of aneurysms are in the anterior circulation, predominately at junctions, or bifurcations along the circle of Willis. Several studies have been conducted by researchers to analyse the blood flow characteristic and flow on the aneurysmal wall, however, there are small numbers of research focus on the fusiform aneurysm and the effect of temperature on the blood flow inside the aneurysm. Thus, this study aims to analyse the body temperature effect on hemodynamic parameters in the fusiform aneurysm. Three different models of the fusiform aneurysm based on patient-specific geometries have been developed and simulated. The computational Fluid Dynamics (CFD) method was imposed in this study to analyse the effect of hemodynamic variables on the different body temperatures by analysing the Wall Shear Stress (WSS) and Oscillatory Shear Index (OSI) at the fusiform aneurysmal wall. The result shows that the WSS values fluctuate with the temperature variations and were observed lowest low at the anterior fusiform aneurysm. The OSI indicates similar results for each physiological condition with the variation of temperature. The high value of WSS and low value of OSI increase the possibility of an aneurysmal wall being ruptured.

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Effect of Hemodynamic Parameters on Physiological Blood Flow through Cardiovascular Disease (CVD) – The Perspective Review

Cited by 5 publications

References 24 publications

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Flow Characteristics on Carotid Artery Bifurcation of Different Aneurysmal Morphology

Temperature Variation with Hemodynamic Effect Simulation on Wall Shear Stress in Fusiform Cerebral Aneurysm

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