IMA and IMAR in serum and saliva of preeclampsia – a preliminary study

D’souza, Jyothi M. P.; Pai, Vidya; Harish, Sindhu; Shriyan, Chitra; Dsouza, Neevan

doi:10.3109/10641955.2014.931418

Cited by 19 publications

(16 citation statements)

References 29 publications

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“…22–24 Hence serum IMA a marker of oxidative stress and hypoxia is elevated in preeclampsia. Our study is in accordance with the studies done by Ustan Y et al, 11 Gafsou et al, 12 Jyothi et al 10 and Jyotirmayee et al 9 who observed elevated levels of serum IMA in preeclampsia in third trimester and Papageoghiour AT et al 3 who observed changes in first trimester.…”

Section: Discussionsupporting

confidence: 93%

“…The elevated levels of serum IMA continued till delivery. Jyotirmayee et al 9 and Jyothi et al 10 in their studies done on pregnant women at 30 ± 4 weeks and 34 ± 4 weeks of gestation respectively, found an elevated levels of serum IMA in preeclampsia.…”

Section: Discussionmentioning

confidence: 89%

“…9,10 Very few studies have demonstrated the correlation of serum IMA with severity of preeclampsia. 11,12 Contradiction to these studies also exists.…”

Section: Introductionmentioning

confidence: 99%

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Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study

Vyakaranam

Bhongir

Patlolla

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Background Hypoxia driven oxidative stress of the placenta contributes to the pathogenesis of preeclampsia. Serum Ischemia Modified Albumin (IMA) has recently emerged as an oxidative stress marker, used in diagnosis of cardiac ischemia. Aim: To determine the efficiency of serum IMA in differentiating hypertensive disorders of pregnancy (pregnancy induced hypertension, preeclampsia) from normal pregnancy. Methods It was a case control study. Pregnant women ≥32 weeks of gestation. Study population were included 3 groups, 19 Normotensive Pregnant (NP) women as controls, 18 pregnant women with Pregnancy Induced Hypertension (PIH) and 19 with preeclampsia (PE). Serum IMA was estimated by Enzyme Linked Immune Sorbent Assay (ELISA). Results were analyzed by student ‘t’test. Critical values for serum IMA were obtained by Receiver Operation Characteristics (ROC) curves. Results Serum IMA levels were significantly elevated in PE (56.84 ± 21.57 ng/ml) when compared with PIH (36.24 ± 14.51 ng/ml) and NP (35.47 ± 11.58 ng/ml) (P value <0.001). With a cutoff of 38.33 ng/ml, sensitivity and specificity for preeclampsia was 88.9% and 73.7% respectively. Conclusions Our study demonstrated that serum IMA, an oxidative stress marker is elevated in PE & PIH. Hence serum IMA can undergo further evaluation as a marker of PE.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 89%

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Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study

Vyakaranam

Bhongir

Patlolla

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…Proteinuria ≥0.3 g in a 24 h urine specimen, protein/creatinine ratio ≥0.3, or urine dipstick protein 1+ was also required for PE diagnosis. Additionally, in a woman with new‐onset hypertension without proteinuria, the new onset of any of the following was considered diagnostic of PE: platelet count <100 000/μL; serum creatinine >1.1 mg/dL or doubling of serum creatinine in the absence of other renal disease; liver transaminase more than twofold the normal level, pulmonary edema; cerebral or visual symptoms …”

Section: Methodsmentioning

confidence: 99%

“…Additionally, in a woman with new-onset hypertension without proteinuria, the new onset of any of the following was considered diagnostic of PE: platelet count <100 000/lL; serum creatinine >1.1 mg/dL or doubling of serum creatinine in the absence of other renal disease; liver transaminase more than twofold the normal level, pulmonary edema; cerebral or visual symptoms. 16,17 The mothers fulfilled the criteria for PE and their premature newborns were included in this study as the PE group. The PE mothers underwent cesarean section due to hypertension and prematurity.…”

Section: Methodsmentioning

confidence: 99%

Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Özdemir

Enli

et al. 2018

Pediatrics International

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Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

et al. 2016

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Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

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IMA and IMAR in serum and saliva of preeclampsia – a preliminary study

Abstract: This study is an evidence for involvement of oxidative stress in the pathogenesis of preeclampsia, which is reflected in serum and saliva. Salivary IMAR could be a better marker for early prediction of preeclampsia.

Cited by 19 publications

References 29 publications

Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study

Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study

Ischemia‐modified albumin in preterm infants born to mothers with pre‐eclampsia

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

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