Illness Experience and Quality of Life in Sjögren Syndrome Patients

Alcayaga, Gonzalo Rojas; Herrera, Andrea; Espinoza, Iris; Rios-Erazo, Matías; Aguilar, Jacqueline; Leiva, Loreto; Shakhtur, Nailah; Wurmann, Pamela; Geenen, Rinie

doi:10.3390/ijerph191710969

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…It revealed a significant increase in their OHIP-14 scores compared to the initial assessment, especially in relation to the physical pain and psychological discomfort subscales [ 7 ]. Similarly, the findings of a recent study showed that OHRQoL in pSS seemed to be frequently impaired, with physical pain and psychological discomfort being the most affected OHIP-14 dimensions, which coincided with our results [ 23 ].…”

Section: Discussionsupporting

confidence: 93%

Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjögren’s Syndrome

et al. 2023

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Background and Objectives: Oral disorders, frequently observed in patients with primary Sjögren’s syndrome, can profoundly affect patients’ daily lives and well-being, as oral health represents a fundamental part of general health. Saliva plays an essential part in maintaining and protecting oral health, so the decrease in its quantity and quality leads to chronic oral discomfort alongside a broad spectrum of problems. The objective of the present study was to evaluate the oral health of patients with primary Sjögren’s syndrome and establish its effect on the different domains of their oral health-related quality of life (OHRQoL). Materials and Methods: The research was designed as an observational case–control study with prospective data collection. Eighty patients, divided into two groups based on their oral status, participated in the study. All subjects underwent a complete oral examination. The OHRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Results: The most prevalent oral manifestation was exfoliative cheilitis, while 30% of subjects complained of chewing and swallowing difficulties. The OHIP-14 summary score was significantly higher in the patients with oral lesions (26.0 (5.0) vs. 17.0 (4.0), respectively; p < 0.001). Oral manifestations, systemic involvement, medication, and periodontal indexes were significantly associated with OHIP-14 scores. Conclusions: Patients with oral alterations had a substantially decreased OHRQoL. These findings emphasize the importance of oral diseases for patients’ well-being. Therefore, it is essential for dentists to be included in the multidisciplinary teams managing primary Sjögren’s syndrome, as improving patients’ oral status would lead to better oral health and enhanced OHRQoL.

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Section: Discussionsupporting

confidence: 93%

Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjögren’s Syndrome

et al. 2023

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“…Sjogren's syndrome (SS) is a high-rate, common, and harmful global disease with higher potential morbidity and is an essential menopausal and aging disease [34][35][36]. The disease is characterized by xerostomia with dysfunction of salivary gland secretion as the initiating factor, which affects the whole body's health [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

The Critical Biomarkers Identification of Insulin Signaling Involved in Initiating cAMP Signaling Mediated Salivary Secretion in Sjogren Syndrome: Transcriptome Sequencing in NOD Mice Model

et al. 2022

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Background Sjogren’s syndrome (SS) is an autoimmune disorder characterized by the destruction of exocrine glands, resulting in dry mouth and eyes. Currently, there is no effective treatment for SS, and the mechanisms associated with inadequate salivary secretion are poorly understood. Methods In this study, we used NOD mice model to monitor changes in mice’s salivary secretion and water consumption. Tissue morphology of the submandibular glands was examined by H&E staining, and Immunohistochemical detected the expression of AQP5 (an essential protein in salivary secretion). Global gene expression profiling was performed on submandibular gland tissue of extracted NOD mice model using RNA-seq. Subsequently, a series of bioinformatics analyses of transcriptome sequencing was performed, including differentially expressed genes (DEGs) identification, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, PPI network construction, hub gene identification, and the validity of diagnostic indicators using the dataset GSE40611. Finally, IFN-γ was used to treat the cells, the submandibular gland tissue of NOD mice model was extracted, and RT-qPCR was applied to verify the expression of hub genes. Results We found that NOD mice model had reduced salivary secretion and increased water consumption. H&E staining suggests acinar destruction and basement membrane changes in glandular tissue. Immunohistochemistry detects a decrease in AQP5 immunostaining within acinar. In transcriptome sequencing, 42 overlapping DEGs were identified, and hub genes (REN, A2M, SNCA, KLK3, TTR, and AZGP1) were identified as initiating targets for insulin signaling. In addition, insulin signaling and cAMP signaling are potential pathways for regulating salivary secretion and constructing a regulatory relationship between target-cAMP signaling-salivary secretion. Conclusion The new potential targets and signal axes for regulating salivary secretion provide a strategy for SS therapy in a clinical setting.

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“…Current limitations in robust screening tools and definitive protocols for DED assessment exacerbate the challenge. Additionally, the profound impact of SS on a patient's quality of life may often be underestimated by clinicians, leading to reduced referrals for comprehensive evaluations [6].…”

Section: Prevalencementioning

confidence: 99%

Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms

Wu,

Serhan,

Faucher

et al. 2024

Biomolecules

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Sjögren’s syndrome dry eye (SSDE) is a subset of Sjögren’s syndrome marked by dry eye symptoms that is distinct from non-Sjögren’s syndrome dry eye (NSSDE). As SSDE can lead to severe complications, its early detection is imperative. However, the differentiation between SSDE and NSSDE remains challenging due to overlapping clinical manifestations. This review endeavors to give a concise overview of the classification, pathophysiology, clinical features and presentation, ocular and systemic complications, clinical diagnosis, and management of SSDE. Despite advancements, limitations in current diagnostic methods underscore the need for novel diagnostic modalities. Thus, the current review examines various diagnostic biomarkers utilized for SSDE identification, encompassing serum, salivary, and tear analyses. Recent advancements in proteomic research and exosomal biomarkers offer promising diagnostic potential. Through a comprehensive literature review spanning from 2016 to 2023, we highlight molecular insights and advanced diagnostic modalities that have the potential to enhance our understanding and diagnosis of SSDE.

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Illness Experience and Quality of Life in Sjögren Syndrome Patients

Cited by 9 publications

References 33 publications

Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjögren’s Syndrome

Oral Health and Oral Health-Related Quality of Life in Patients with Primary Sjögren’s Syndrome

The Critical Biomarkers Identification of Insulin Signaling Involved in Initiating cAMP Signaling Mediated Salivary Secretion in Sjogren Syndrome: Transcriptome Sequencing in NOD Mice Model

Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms

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