Illiteracy and the incidence of Alzheimer's disease in the Yonchon County survey, Korea

Lee, Jun-Young; Chang, Sung Man; Jang, Hye Sook; Chang, Jae Seung; Suh, Guk-Hee; Jung, Hee-Yeon; Jeon, Hong-Jin; Cho, Maeng Je

doi:10.1017/s1041610208007333

Cited by 29 publications

(24 citation statements)

References 17 publications

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“…In a previous study on the incidence of AD in elderly Korean subjects living in Yonchon, a rural agricultural area, the incidence rate of AD was estimated to be much higher than that found in the current study (12.6 cases per 1,000 person-years in the rural subsample vs. 7.9 cases per 1,000 person-years in the total sample), with 15.8 (95% CI 12.9-17.3) cases per 1,000 person-years at the 3.5-year follow-up [5] and 21.0 (95% CI 16.5-26.4) cases per 1,000 person-years at the 5.5-year follow-up [6]. This difference in the estimated incidence may be attributed to the difference in the educational level of the participants between the 2 studies.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of MCI has never before been investigated in Asian countries, including Korea. Although one study has previously been published on the incidence of AD in Korea [5,6], the estimate may not represent the incidence of AD in the elderly Korean population and requires verification as the study was conducted in a rural population and the estimated incidence of AD was much higher than that of other Asian and Western countries [7,8,9]. Many potential risk factors for AD reported in previous prevalence studies [2,10,11,12] have never been verified by prospective incidence studies in Korea.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Bae

Kim

Han

et al. 2014

Dement Geriatr Cogn Disord

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Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD. © 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Bae

Kim

Han

et al. 2014

Dement Geriatr Cogn Disord

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“…3,4 Illiteracy is the extreme end of low education, which was not uncommon in aged population of our country due to the specific historical situation. 5 It was reported to increase the To understand the clinical characteristics of dementia depending on the educational level, we performed a cross-sectional study comparing the two contrasting groups, illiterate patients vs. highly educated (more than 9 years of formal education) individuals, within the same clinical stage of mild AD dementia.…”

Section: Introductionmentioning

confidence: 99%

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

Shin

Lee

et al. 2015

Dement Neurocognitive Disord

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Background and Purpose Cognitive reserve is important for the individual susceptibility to dementia. Among the various determinants of cognitive reserve, the number of years of formal education would be of prime importance. We performed this study to explore its contribution to the clinical characteristics of dementia. Methods We included consecutive mild Alzheimer's disease (AD) dementia patients (clinical dementia rating, CDR=0.5 or 1) who visited our memory clinic and were older than 70 years at the evaluation from October 2013 to September 2015. According to the number of years of education, the corresponding subjects was grouped into two extreme educational groups, low education (illiterate or partially illiterate, LE, n=43) vs. high education (more than 9 years of education, HE, n=34). Among these patients, we compared various demographic, neuropsychological and neuroimaging characteristics. Results The groups were comparable in terms of age, frequency of hypertension and diabetes, and CDR and its sum of box. However, female gender was more frequent in the LE group (p=0.000). Also this group showed a more depressive mood on the geriatric depression scale (p=0.007). The raw scores on Korean Version of Mini-Mental State Examination and well-validated neuropsychological tests were lower in the LE group. However, the cognitive performance was found to be more preserved in the LE group than in the HE group when assessed using the z-score in certain specified tests on univariate and multivariate analyses (p<0.05). The Schelten's grade of medial temporal atrophy was similar between the two educational groups. Also, the degree of combined ischemic burden did not differ between the two groups. Conclusions We identified that the prevalence of depressive mood and the extent of decline from the corresponding norm in a particular neuropsychological performance differ according to the educational level of mild AD patients.

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“…Uma nova forma de acesso à informação se torna disponível, o que amplia consideravelmente as possibilidades de desenvolvimento do indivíduo, seja no âmbito social, emocional, cognitivo ou cerebral. Sabe-se hoje que não saber ler e escrever é um fator de risco para o desenvolvimento de demências (Brucki, 2010) e que a doença de Alzheimer progride mais rapidamente entre as pessoas que não leem do que entre as pessoas que leem (Lee et al, 2008). …”

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Tarefas de Nomeação Seriada Rápida: Rastreando a Dificuldade de Leitura

Justi

Paula

2016

Psic.: Teor. e Pesq.

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RESUMO -Este estudo analisou a precisão de medidas de nomeação seriada rápida (NSR) em identificar os estudantes em risco/sem risco de dificuldade de leitura. Tarefas de NSR requerem a nomeação rápida de diferentes estímulos visuais apresentados em um cartão. Duzentas e treze crianças realizaram as tarefas de NSR quando estavam na Educação Infantil e, dessas, 174 realizaram uma tarefa de leitura quando estavam no 1º ano do Ensino Fundamental. Análises da curva ROC (Receiver Operating Characteristic) indicaram que as medidas de NSR (objetos, cores, números e letras) são razoáveis em identificar o risco/não risco de dificuldade de leitura (área sob a curva ≥ 0,70), sendo a NSR de números a medida com melhores índices de sensibilidade (88%) e especificidade (50%).Palavras-chave: nomeação seriada rápida, rastreamento, leitura, distúrbios da leitura Rapid Automatized Naming Tasks: Screening Reading DifficultyABSTRACT -The aim of this study was to analyze the rapid automatized naming (RAN)'s accuracy for identifying students at risk/not at risk for reading difficulty. Two hundred and thirteen children performed the RAN tasks when they were in the last year of Kindergarten and 174 among them, accomplished the reading task when they were in the first grade of Elementary School. Analyses based on the ROC curve (Receiver Operating Characteristic) indicated that all the RAN measures (objects, colors, numbers, and letters) had a fair accuracy for identifying students at risk/not at risk for reading difficulty (AUC ≥ 0.70). RAN numbers had the best classification accuracy presenting sensitivity and specificity indexes of 88% and 50%, respectively. O aprendizado da leitura representa um marco muito importante no desenvolvimento do ser humano. Uma nova forma de acesso à informação se torna disponível, o que amplia consideravelmente as possibilidades de desenvolvimento do indivíduo, seja no âmbito social, emocional, cognitivo ou cerebral. Sabe-se hoje que não saber ler e escrever é um fator de risco para o desenvolvimento de demências (Brucki, 2010) e que a doença de Alzheimer progride mais rapidamente entre as pessoas que não leem do que entre as pessoas que leem (Lee et al., 2008). Keywords

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Illiteracy and the incidence of Alzheimer's disease in the Yonchon County survey, Korea

Abstract: Illiteracy is associated with a higher risk of AD and the risk increases with age.

Cited by 29 publications

References 17 publications

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

Incidence of and Risk Factors for Alzheimer's Disease and Mild Cognitive Impairment in Korean Elderly

The Clinical Characteristics according to the Educational Level in the Elderly Patients with Mild Alzheimer's Disease Dementia

Tarefas de Nomeação Seriada Rápida: Rastreando a Dificuldade de Leitura

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