Ilicicolinic acids and ilicicolinal derivatives from the fungus Neonectria discophora SNB-CN63 isolated from the nest of the termite Nasutitermes corniger found in French Guiana show antimicrobial activity

Sorres, Jonathan; Sabri, Abir; Brel, Orianne; Stien, Didier; Éparvier, Véronique

doi:10.1016/j.phytochem.2018.04.003

Cited by 14 publications

(18 citation statements)

References 25 publications

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“…Indeed, the ethyl alcohol extract of Nasutitermes corniger (termites) enhanced the effectiveness of antibiotics, by a significant reduction of antibiotics MIC value against S. aureus and E. coli [ 140 , 141 ]. Two compounds, ilicicolinic acids and ilicicolinal derivatives obtained from Neonectria discophora (isolated from the nest of N. corniger ), depicted significant antibacterial activity (MIC <16 mg/L) against T. rubrum, S. aureus and MRSA [ 142 ].…”

Section: Medicinal Plants: the Main Natural Source For Specific And Pmentioning

confidence: 99%

Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Seukep

Kuete

Nahar

et al. 2020

Journal of Pharmaceutical Analysis

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The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The major factor in MDR is efflux pump-mediated resistance. A unique pump can make bacteria withstand a wide range of structurally diverse compounds. Therefore, their inhibition is a promising route to eliminate resistance phenomenon in bacteria. Phytochemicals are excellent alternatives as resistance-modifying agents. They can directly kill bacteria or interact with the crucial events of pathogenicity, thereby decreasing the ability of bacteria to develop resistance. Numerous botanicals display noteworthy efflux pumps inhibitory activities. Edible plants are of growing interest. Likewise, some plant families would be excellent sources of efflux pump inhibitors (EPIs) including Apocynaceae, Berberidaceae, Convolvulaceae, Cucurbitaceae, Fabaceae, Lamiaceae, and Zingiberaceae. Easily applicable methods for screening plant-derived EPIs include checkerboard synergy test, berberine uptake assay and ethidium bromide test. In silico high-throughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics, thereby improving the selection process and extending the identification of EPIs. To ascertain the efflux activity inhibition, real-time PCR and quantitative mass spectrometry can be applied. This review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification.

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Section: Medicinal Plants: the Main Natural Source For Specific And Pmentioning

confidence: 99%

Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Seukep

Kuete

Nahar

et al. 2020

Journal of Pharmaceutical Analysis

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“…It was determined to have ≥95% purity by analytical HPLC. The chemical structure of ili A was further determined by comparing the spectroscopic data ( Supplementary Figure S3 ) with the literature ( Sorres et al, 2018 ). Other chemicals were purchased from Sigma Aldrich (St. Louis, MO, United States) unless specified otherwise.…”

Section: Methodsmentioning

confidence: 99%

“…Intriguingly, ilicicolin A (Ili-A) is an ascochlorin derivative isolated from theBeibu Gulf coral-derived fungus Acremonium sclerotigenum GXIMD 02501. Ili-A has been reported to be a promising anti-tumor drug in recent studies ( Nirma et al, 2015 ; Sorres et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway

et al. 2021

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The Polycomb protein enhancer of zeste homolog 2 (EZH2) has critical roles in prostate cancer (PCa) progression and drug-resistance, which remains an obstacle for PCa treatment. Enzalutamide (ENZ) is a second-generation androgen receptor antagonist employed for treatment of metastatic castration-resistant prostate cancer A considerable proportion of tumors eventually develop resistance during treatment. Thus, agents that can overcome resistance to PCa are needed urgently. Ilicicolin A (Ili-A), an ascochlorin derivative isolated from the coral-derived fungus Acremonium sclerotigenum GXIMD 02501, shows antiproliferative activity in human PCa cells, but its mechanism of action against Castration-resistant prostate cancer is not known. Herein, RNA-sequencing showed the EZH2 pathway to be involved in PCa proliferation. Ili-A at low doses reduced the protein level of EZH2, leading to transcriptional change. Interestingly, Ili-A suppressed the binding of EZH2 to promoter regions in AR/serine/threonine polo-like kinase-1/aurora kinase A. Moreover, Ili-A could enhance the anticancer activity of enzalutamide in CRPC cancer models. These data suggest that Ili-A could be used in combination with enzalutamide to treat CRPC.

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“…The ITS sequence was deposited in the NCBI GenBank database under the registry number KC692746 corresponding to SNB-TR1 strain. The tests were conducted in accordance to the reference protocols from the European Committee on Antimicrobial Susceptibility Testing [ 23 , 24 , 25 , 26 ]. The standard microdilutions, ranging from 256 to 0.25 μg/mL were made from stock solutions prepared in DMSO (Sigma-Aldrich, France).…”

Section: Methodsmentioning

confidence: 99%

Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island

et al. 2020

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With the occurrence of antibiotic-resistant Staphylococcus aureus strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against S. aureus. Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were first isolated from the ethyl acetate extract of P. mauritianum leaves. Their structures were elucidated from spectroscopic data. Aspidin VB exhibited strong antibacterial activity against standard and methicillin-resistant S. aureus strains, with a minimal inhibition concentration (MIC) of 0.25 μg/mL, and no cytotoxicity was observed at 10−5 M in MRC5 cells. Due to its biological activities, Aspidin VB appears to be a good natural lead in the fight against S. aureus.

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Ilicicolinic acids and ilicicolinal derivatives from the fungus Neonectria discophora SNB-CN63 isolated from the nest of the termite Nasutitermes corniger found in French Guiana show antimicrobial activity

Cited by 14 publications

References 25 publications

Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway

Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island

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