Iliac Vein Compression Syndrome in an Active and Healthy Young Female

Cerquozzi, Sonia; Pineo, Graham F.; Wong, Jason; Valentine, Karen

doi:10.1155/2012/786876

“…9 Similarly, other investigators reported three to eight times higher frequency of iliac vein compression of the left LL than that of right-side among asymptomatic patients. 23,24 Kibbe et al., 24 observed that one-fourth of the asymptomatic patients that underwent CT scans for other medical reasons identified to have >50% compression of the left iliac vein.…”

Section: Discussionmentioning

confidence: 99%

Clinical implications of the anatomical variation of deep venous thrombosis

El‐Menyar

¹

,

Asim

²

,

Jabbour

³

et al. 2017

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Introduction Little is known about the anatomic variation and its implication in patients with lower limb deep venous thrombosis (DVT). We studied the clinical presentation, site of thrombosis and risk factors based on the anatomic distribution of lower limb DVT. Methods A retrospective analysis of clinically suspected DVT cases was conducted between 2008 and 2012. DVT was categorized by the location of the thrombosed segment and limb involved. The DVT anatomic segments were assessed according to left-to-right ratio, predisposing factors and clinical presentations. Results A total of 637 patients with DVT were included with a mean age of 50 ± 17 years (51%; females). The most frequently thrombosed segments were popliteal, posterior tibial and profunda femoris veins. DVT was more common at the left side, with a left-to-right ratio of 1.5:1. Bilateral DVT cases (38.5%) had more prior history of DVT as compared to left- (20.3%) and right-sided DVTs (22.6%); p = 0.01. Bilateral DVT was complicated more with post-thrombotic syndrome (leg ulcer) ( p = 0.02). The rates of pulmonary embolism (25%) and mortality (23.1%) were significantly higher for bilateral DVT in comparison to left- and right-sided DVT. Abnormal coagulation profile was significantly associated with posterior tibial DVT (81% vs. 71.4%; p = 0.01) as compared to patients with normal coagulation profile. Conclusion Lower limb DVTs are more common at the left side; however, patients with bilateral DVT have higher frequency of recurrence, post-thrombotic syndrome, pulmonary embolism and mortality. The anatomic segments of DVT show specific distribution depending on the predisposing factors. These findings could improve our understanding of the pathophysiology and management of DVT patients.

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“…There are 3 published reports of otherwise‐healthy female patients presenting after running with left lower limb DVT with associated MTS [8‐10]. All had known risk factors, including oral contraceptive use; one patient also had a family history of DVT [8], whereas a second patient was found to be heterozygous for the Leiden V mutation [9].…”

Section: Discussionmentioning

confidence: 99%

“…There are 3 published reports of otherwise‐healthy female patients presenting after running with left lower limb DVT with associated MTS [8‐10]. All had known risk factors, including oral contraceptive use; one patient also had a family history of DVT [8], whereas a second patient was found to be heterozygous for the Leiden V mutation [9]. An additional case report describes a female with lower extremity swelling and discomfort during running associated with iliac vein compression on venography but no finding of thrombosis [11].…”

Section: Discussionmentioning

confidence: 99%