Ileal nutritional function after one-stage orthotopic ileum transplantation in the growing pig: Reversal of lethal short bowel syndrome

Pakarinen, Mikko P.; Kuusanmãki, Pekka; Halttunen, Jorma

doi:10.1016/s0022-3468(96)90675-2

Cited by 14 publications

(22 citation statements)

References 30 publications

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“…The majority of studies used domestic pigs or piglets [5,13,16,17,18,19] mainly of female gender [10,13,16,18,20,21,22,23,24,25,26,27,28,29]. Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used.…”

Section: Resultsmentioning

confidence: 99%

“…The age as well as the weight [7,10,18,25,27,28,30,31,36] of the pigs at the time of surgery varied widely. In some cases, the pigs were younger than 7 days [21,29,34,37], but in most cases they were between 3 and 8 weeks [13,16,18,20,24,26,27,28,32,33].…”

Section: Resultsmentioning

confidence: 99%

“…Seventy-three percent of the authors performed a resection of 75% [10,13,16,18,21,22,24,26,27,28,32,33,34] or 80% of the small bowel [5,29,30,35,37], and in 8 and 19% of the articles, 90% [19,23] and 95-100% [7,25,30,31,36] of the small bowel was resected, respectively. The bowel was resected in two main areas: most of the authors described a mid-intestinal resection in which the remaining small bowel consists of equal parts of the jejunum and ileum [5,10,18,21,22,27,28,29,30,31,34,35]; other authors used a 75% resection model in which the jejunum was resected 0.5 [24,26,32] to 1 m [20,33] distal of the ligament of Treitz proximally and the ileum up to 2.5 m proximal to the ileocecal valve distally [13,16,20,24,26,32,33].…”

Section: Resultsmentioning

confidence: 99%

“…In those publications that described the surgical technique in detail, only end-to-end anastomoses were reported [5,21,22,24,26,29,32,34,35,37]; the anastomoses were mainly performed in a single-layer technique [5,10,19,25,26,27,28,32] with interrupted sutures [21,22,24,26,27,28,32,34,35,37]. Running sutures were rarely observed [10,18,25]. While the use of 4-0, 5-0 and 8-0 silk sutures was reported, other nonabsorbable sutures such as 4-0 polypropylene were also described [19,27,28,35,37].…”

Section: Resultsmentioning

confidence: 99%

“…However, the material was predominantly nonmonofilament absorbable sutures such as 5-0 Dexon [24,26,32] or 4-0 Polysorb [21,22]. Anastomoses with monofilament absorbable sutures such as 5-0 polyglyconate [25] or 3-0 polydioxanone [10] were also performed. …”

Section: Resultsmentioning

confidence: 99%

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Models of Short Bowel Syndrome in Pigs: A Technical Review

Weih

Nickkholgh²,

Keßler³

et al. 2013

Eur Surg Res

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Background: Short bowel syndrome (SBS) is still a life-threatening disease in both children and adults. Although the therapeutic options are improving, challenges still remain, and to overcome these challenges is a major focus of SBS research today. In order to simulate anatomical and physiological conditions similar to those in humans for research, porcine models of SBS are often used. Various approaches for generating SBS models have been described in the literature. Methods/Results: In this work, we present a review of different types of porcine models of SBS and outline the differences between those models regarding types of animals, surgical procedures, monitoring, and methods of assessment. Conclusion: The aim of this study was to select the most suitable SBS model regarding the purpose of the research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Models of Short Bowel Syndrome in Pigs: A Technical Review

Weih

Nickkholgh²,

Keßler³

et al. 2013

Eur Surg Res

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Effect of orthotopic small bowel transplantation on mineral metabolism in an experimental model

Kastl

Müller

Kotschenreuther

et al. 2005

British Journal of Surgery

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Effect of ileal autotransplantation on cholesterol, bile acids, and biliary lipids in pigs with proximal small bowel resection

et al. 1997

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Small bowel transplantation (SBT) has recently been apOur major aim was to investigate the consequences plied to clinical use among patients with short bowel synof ileal autotransplantation in pigs with proximal small drome or end-stage intestinal failure. 1 Despite advances in intestinal resection on biliary lipids and metabolism of immunosuppression and patient survival, 1 the effects of SBT bile acids. Biliary lipid secretion rates and bile acid abon many aspects of enteric and hepatic physiology remain sorption were assessed by measuring dietary and biliary unknown. 2 Although SBT impairs intestinal absorption and lipids, fractional cholesterol absorption, and fecal excremotility, 2,3 even segmental grafts may provide adequate abtion of cholesterol and bile acids. In addition, serum bile sorptive function in adult recipients. 1,4 Furthermore, a signifacids and cholesterol, biliary and fecal bile acid species, icant component of the potential patient population for SBT and ileal villus height were determined after resection is comprised of children, 1,5 and segmental grafts harvested of the proximal 75% of the jejunoileum (n Å 15) and autofrom living, related adult donors could, in theory, be transtransplantation of the remaining ileum with systemic planted to pediatric recipients. For this reason, and because venous drainage (n Å 15) or transection (n Å 5). Autoileum possesses unique absorptive functions such as active transplantation further increased fecal excretion of neuuptake of bile acids, cobalamin, and sodium, we have develtral and acidic steroids and serum concentration of bile oped a model of autotransplantation in growing pigs to assess acids after proximal resection (P õ .05 for all); autotranschanges in enteric and hepatic function after resection of the plantation significantly decreased serum cholesterol, ilproximal 75% of the jejunoileum and autotransplantation of eal villus height, fractional bile acid and cholesterol abthe remaining ileum.6 sorption, and biliary molar percentage of total and Normally, conjugated bile acids solubilize products of lipid primary bile acids, whereas biliary secretion of bile digestion along the proximal small bowel, but these are not acids, enriched by secondary bile acids, and cholesterol efficiently absorbed until in the distal ileum. The absorbed remained unchanged. At 14 weeks, ileal villus height, bile acids are readily extracted from portal venous and hefractional bile acid and cholesterol absorption, biliary patic arterial blood by hepatocytes, where they exert negative molar percentage of bile acids, and proportion of secondfeedback on their own synthesis. Biliary secretion completes ary biliary bile acids were altered by transplantation enterohepatic circulation of bile acids and also induces secrefrom the respective postresection values of 864 { 22 mm, tion of cholesterol and phospholipids. During enterohepatic 97.9 { 0.6%, 26.9 { 3.9%, 91.8 { 1.2% and 9.2 { 1.3% to 428 circulation, bile acids undergo bacterial modifications that { 21 mm, 91.1 { 1.5%,...

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Ileal nutritional function after one-stage orthotopic ileum transplantation in the growing pig: Reversal of lethal short bowel syndrome

Cited by 14 publications

References 30 publications

Models of Short Bowel Syndrome in Pigs: A Technical Review

Models of Short Bowel Syndrome in Pigs: A Technical Review

Effect of orthotopic small bowel transplantation on mineral metabolism in an experimental model

Effect of ileal autotransplantation on cholesterol, bile acids, and biliary lipids in pigs with proximal small bowel resection

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