Ileal intussusception secondary to small bowel metastases from melanoma

Butte, Jean M.; Meneses, Manuel; Waugh, Enrique; Parada, Hugo; Fuente, Hernán De La

doi:10.1016/j.amjsurg.2008.09.018

Cited by 17 publications

(14 citation statements)

References 3 publications

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“…Superficial spreading melanoma is the most common type of melanoma (70-80%) and therefore responsible for most gastrointestinal metastases, which can develop even more than 10 years after resection of the primary cutaneous lesion. 4,7,8 Around 60% of the patients who suffer from melanoma have small bowel metastases at the moment of death, but in only 1-4% of the cases they are detected as complications occur. 4 These include abdominal pain, intestinal obstruction, weight loss or anemia due to chronic enterorrhagia.…”

Section: Discussionmentioning

confidence: 99%

Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature

Alvarez

Nicolás

Goransky

et al. 2011

International Journal of Surgery Case Reports

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The small intestine is a frequent site of melanoma metastases and the most common cause of secondary intestinal tumors. Even though, its presentation with intestinal obstruction due to intussusception is very rare. We present a 47-year-old woman with a medical history of facial melanoma operated 17 years ago and recently diagnosed of cervical recurrence who complained of abdominal pain of one week duration accompanied with vomiting and abdominal distension. Computed tomography (CT) scan revealed marked distension of the small intestine with features suggesting intussusception of the distal ileum. At laparoscopic exploration a massive ileocolic intussusception was found with invagination of the last 60 cm of ileum inside the cecum and ascending colon. Surgical reduction revealed a tumor of approximately 2 cm in the distal end of the intussuscepted intestine acting as the lead point. Resection of non-viable ileum along with the tumor and end-to-end anastomosis was performed. Many other lesions of smaller size were found distantly in the proximal small bowel but were not treated. The patient had a full recovery and was discharged three days after surgery. Pathological examination showed metastatic melanoma and a positron emission tomography (PET) scan confirmed disseminated disease with brain metastasis. The patient died three months after surgery. Intestinal occlusion due to metastatic disease is a rare condition but should be taken into account particularly in patients with history of cancer. Surgical intervention with a mini-invasive laparoscopic approach is feasible. Intestinal resection and anastomosis is mandatory for either curative or palliative intentions providing a satisfactory treatment.

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Section: Discussionmentioning

confidence: 99%

Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature

Alvarez

Nicolás

Goransky

et al. 2011

International Journal of Surgery Case Reports

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“…The most common site of metastasis of melanoma gastrointestinal tract described in literature is the small intestine [1][2][3][4][5][6][7][8]. In our case, unlike other, we described simultaneous metastasis of melanoma in the stomach, small and large intestine.…”

Section: Discusionmentioning

confidence: 40%

Multiple Simultaneos Metastases of Malignant Melanoma in the Stomach, Small and Large Intestine

Vukmirović

2013

Maced J Med Sci

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“…The time between primary melanoma diagnosis and the development of digestive system metastases varies between 2 and 180 months (8). In the case of small intestinal malignant melanoma, surgical resection is the first-line treatment option, due to acceptable mortality and morbidity rates and the beneficial effect over the course of the disease (9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

Intestinal obstruction due to primary intestinal melanoma in a patient with a history of rectal cancer resectioning: A case report

Tang

et al. 2013

Molecular and Clinical Oncology

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Abstract. The vast majority of the cases of intestinal melanomas are metastatic lesions, originating from an occult primary cutaneous or ocular lesion, whereas primary small intestinal melanomas are extremely rare. This is a rare case of primary small intestinal malignant melanoma with intestinal obstruction in a patient with a prior history of rectal cancer resection. The patient was admitted for abdominal pain and obstipation. Following an overall inspection, the patient was subjected to surgical treatment and a small intestinal tumor was removed. The histopathological examination of the lesion revealed a diffuse neoplastic infiltration involving the entire thickness of the intestinal mucosa. The neoplastic cells exhibited marked atypia, pleomorphism and immunoreactivity to S-100, anti-melanoma antibody (HMB-45) and melanocyte̸melanoma tumor antigen (Melan-A). The diagnosis of primary small intestinal melanoma was confirmed. The patient underwent an uneventful postoperative recovery and was administered adjuvant therapy. At the 3-month, 6-month and 1-year follow-up, the patient remained alive, with no signs of tumor metastasis and/or recurrence. In this case, the patient was repetitively assessed by abdominal computed tomography (CT) and plain film, confirming that the obstruction was caused by small intestinal melanoma. There was no association between the rectal cancer history and the melanoma. A definitive diagnosis requires detailed clinical, histopathological and immunohistochemical analyses.

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Ileal intussusception secondary to small bowel metastases from melanoma

Cited by 17 publications

References 3 publications

Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature

Ileocolic intussusception due to intestinal metastatic melanoma. Case report and review of the literature

Multiple Simultaneos Metastases of Malignant Melanoma in the Stomach, Small and Large Intestine

Intestinal obstruction due to primary intestinal melanoma in a patient with a history of rectal cancer resectioning: A case report

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