ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery

Jakob, Manuel O.; Spari, Daniel; Sánchez-Taltavull, Daniel; Salm, Lilian; Yılmaz, Bahtiyar; Ladevèze, Rémi Doucet; Mooser, Catherine; Pereyra, David; Ouyang, Ye; Schmidt, Theresa; Mattiola, Irene; Starlinger, Patrick; Stroka, Deborah; Tschan, Franziska; Candinas, Daniel; Gasteiger, Georg; Klose, Christoph S. N.; Diefenbach, Andreas; Agüero, Mercedes Gomez de; Beldi, Guido

doi:10.1016/j.celrep.2023.112269

Cited by 5 publications

(2 citation statements)

References 91 publications

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“…They also induce angiogenesis, promote wound healing, inhibit pro-inflammatory reactions, modulate adaptive cellular immune responses, and act as chemoattractants for immune cells [ 34 , 35 , 36 , 37 , 50 , 51 , 52 , 53 ]. Therefore, AMPs play a role in controlling infections [ 66 ] and may have therapeutic potential even in mixed infections or biofilm-associated infections [ 67 ]. However, bacteriocins (AMPs derived from bacteria), often have a limited spectrum of antimicrobial activity against other bacteria that are phylogenetically related [ 68 ].…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics

Marissen,

Reichert,

Härtel

et al. 2024

IJMS

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Antimicrobial peptides (AMPs) are crucial components of the innate immune system in various organisms, including humans. Beyond their direct antimicrobial effects, AMPs play essential roles in various physiological processes. They induce angiogenesis, promote wound healing, modulate immune responses, and serve as chemoattractants for immune cells. AMPs regulate the microbiome and combat microbial infections on the skin, lungs, and gastrointestinal tract. Produced in response to microbial signals, AMPs help maintain a balanced microbial community and provide a first line of defense against infection. In preterm infants, alterations in microbiome composition have been linked to various health outcomes, including sepsis, necrotizing enterocolitis, atopic dermatitis, and respiratory infections. Dysbiosis, or an imbalance in the microbiome, can alter AMP profiles and potentially lead to inflammation-mediated diseases such as chronic lung disease and obesity. In the following review, we summarize what is known about the vital role of AMPs as multifunctional peptides in protecting newborn infants against infections and modulating the microbiome and immune response. Understanding their roles in preterm infants and high-risk populations offers the potential for innovative approaches to disease prevention and treatment.

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Section: Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics

Marissen,

Reichert,

Härtel

et al. 2024

IJMS

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“…This initiates release of chemokines and cytokines such as TNF-α, IL-1β and IL-23, some of which induce subsequent production of additional cytokines including IFNγ and IL-22 by lymphoid cells (8). IL-22, which is primarily produced by type 3 innate lymphoid cells (ILCs), γδ T cells and Th17 cells, is a mediator of immune defense against extracellular pathogens at mucosal organs (9)(10)(11)(12)(13). During pulmonary infections, IL-22 induces expression of antimicrobial peptides, tight junction proteins and complement factors by lung epithelial cells and hepatocytes, respectively (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

Röwekamp,

Maschirow,

Rabes

et al. 2023

Preprint

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IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals, and that single nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect of IL-33 on S. pneumoniae infection was mediated by negative regulation of IL-22 production in innate lymphoid cells (ILCs), but independent of ILC2s as well as IL-4 and IL-13 signaling. Moreover, IL-33's influence on antibacterial defense was dependent on housing conditions of the mice, and mediated by the modulatory effect of IL-33 on the microbiota. Collectively, we provide insight into the bidirectional crosstalk between the innate immune system and the microbiota. We identify a mechanism, dependent on both genetic and environmental factors, that impacts the efficacy of antibacterial immune defense and thus susceptibility to pneumonia.

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Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

Rodrigues,

van der Merwe,

Krag

et al. 2024

Seminars in Immunology

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ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery

Cited by 5 publications

References 91 publications

Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics

Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

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