IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis

Abstract

BackgroundInterleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.MethodsWe examined 422 RA patients and 337 subjects as a control group. Single nucleotide polymorphism (SNP) in the IL17A (rs2275913) and IL17F (rs763780, rs11465553, rs2397084) genes were genotyped using TaqMan genotyping assays from Life Technologies Genomic.ResultsThere were no significant differences in distribution of IL17A and IL17F genotypes and alleles between RA patients and control group. There were no significant associations between IL17A and IL17F genotypes and age of disease diagnosis rheumatoid factor, erosive disease as well as extra-articular manifestations.ConclusionsThe results of this study suggest, that IL17A and IL17F gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of RA in a Polish population.

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

“…Finally, seven studies including 1,409 RA patients and 1,303 controls were eligible for the present study. [13][14][15][16][17][18][19] The flow chart of the literature research and study selection is shown in Figure 1. Among the included studies, all seven investigated the correlation between 7488A/G and RA susceptibility, but only four (containing 1,093 cases and 969 controls) researched 7383A/G and RA risk.…”

“…Among the included studies, all seven investigated the correlation between 7488A/G and RA susceptibility, but only four (containing 1,093 cases and 969 controls) researched 7383A/G and RA risk. 13,14,16,19 Moreover, in the study of Louahchi et al, 19 only allele data could be extracted. The main characteristics of these studies are shown in Table 1.…”

“…26,27 Recently, three polymorphisms of IL-17F in RA have been studied. 14,16 In the present study, we focused on the association of the two variants IL-17F 7488A/G, which changes amino acid 161 in exon 3 from histidine (A allele) to arginine (G allele), and 7383A/G, which leads to the changes of amino from glutamic acid (A allele) to glycine (G allele), with RA risk. Both variants might influence molecular structure and biological function of the protein.…”

“…14,15 However, it is undeniable that the results remained inconsistent among studies due to the instability of trend in different publications. For instance, the positive relationship between IL-17F 7488A/G and RA risk reported by Bogunia-Kubik et al 15 could not be replicated by Pawlik et al 16 even in the same population. It is necessary to carry out a comprehensive study to summarize those inconsistent results.…”

Association of IL-17A -197G/A (rs2275913) Single Nucleotide Polymorphism and Rheumatoid Arthritis in Sudanese Patients

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by a chronic in ammatory response that affects various part of the human body. At late stages, RA leads to deformities of the joints and bones causing severe pain [1][2][3][4][5]. Certain factors were hypothesized to be involved in the induction and the development of RA; however, the most acceptable theory for the development of the disease is a multifactorial theory that involve the interaction of environmental and genetic background of patients and render them more susceptible to RA [6].…”