IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years

Raedler, Diana; Illi, Sabina; Pinto, Leonardo Araújo; Mutius, Erika von; Illig, Thomas; Kabesch, Michael; Schaub, Bianca

doi:10.1016/j.jaci.2012.08.008

Cited by 35 publications

(32 citation statements)

References 48 publications

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“…In addition to the detection of specific IgE to mites as an outcome, the genetic influences on the immune response to mites have been supported by cell assays showing that upon stimulation with mite allergens, the peripheral blood mononuclear cells produce different cytokine levels depending on the carrier status of risk genotypes [82, 83]. Besides, recent studies revealed that epigenetic changes might influence the susceptibility to mite sensitization by modifying DNA methylation in B cells [84], and the hypomethylation of the interleukin 13 gene [85].…”

Section: Genetics Of Ige Responses To Mite Allergensmentioning

confidence: 99%

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Sánchez‐Borges

Fernández-Caldas

Thomas

et al. 2017

World Allergy Organization Journal

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Since mite allergens are the most relevant inducers of allergic diseases worldwide, resulting in significant morbidity and increased burden on health services, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), formed by the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI), the European Academy of Allergy and Clinical Immunology (EAACI), and the World Allergy Organization (WAO), has proposed to issue an International Consensus (ICON) on the clinical consequences of mite hypersensitivity. The objectives of this document are to highlight aspects of mite biology that are clinically relevant, to update the current knowledge on mite allergens, routes of sensitization, the genetics of IgE responses to mites, the epidemiologic aspects of mite hypersensitivity, the clinical pictures induced by mites, the diagnosis, specific immunotherapeutic approaches, and prevention.

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Section: Genetics Of Ige Responses To Mite Allergensmentioning

confidence: 99%

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Sánchez‐Borges

Fernández-Caldas

Thomas

et al. 2017

World Allergy Organization Journal

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“…91 The skin barrier abnormality caused by FLG mutations is also associated with increased serum 25-hydroxy vitamin D concentrations. 92 Polymorphisms located within the overlapping anoctamin 3 (ANO3) and mucin 15 (MUC15) genes, 93 as well as the IL10 gene, 94 have been associated with AD.…”

Section: Genetic Influences In Admentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

Sicherer

Leung

2013

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012. Studies support an increase in peanut allergy prevalence in children and exposure to the antibacterial agent triclosan and having filaggrin (FLG) loss-of-function mutations as risk factors for food sensitization. The role of specific foods in causing eosinophilic esophagitis is elucidated by several studies, and microRNA analysis is identified as a possible noninvasive disease biomarker. Studies on food allergy diagnosis emphasize the utility of component testing and the possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinformatics. Treatment studies of food allergy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional therapies are under study. Studies on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the need for prompt treatment with epinephrine. Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. Numerous studies support influenza vaccination of persons with egg allergy using modest precautions. Evidence continues to mount that there is cross-talk between skin barrier defects and immune responses in patients with atopic dermatitis. Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease.

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“…Therefore, our findings suggest that some impairment of the TLR2 downstream signaling pathway may exist at birth in the monocytes of infants who are susceptible to developing AD. Genetic polymorphisms of IL-10 may also play a role in reducing the release of IL-10 [17, 18], although IL-10 polymorphisms were not examined in this study.…”

Section: Discussionmentioning

confidence: 99%

Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with <b><i>Bifidobacterium</i></b> Colonization

Suzuki

Campos-Alberto

Morita

et al. 2018

Int Arch Allergy Immunol

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Background: Altered regulatory immune responses to microbial stimuli and intestinal colonization of beneficial bacteria early in life may contribute to the development of allergic diseases (e.g., atopic dermatitis [AD]). However, few reports have investigated these factors simultaneously. The purpose of this study was to analyze neonatal immune responses to microbial stimuli as well as intestinal colonization of beneficial bacteria, in relation to the development of AD in a birth cohort. Methods: Pregnant women were recruited, and their infants were followed up until 7 months of age. Levels of interleukin (IL)-10 released from cord-blood mononuclear cells (CBMCs) stimulated with heat-killed gram-positive bacteria (Bifidobacterium bifidum and Lactobacillus rhamnosus GG) and Lactobacillus-derived peptidoglycan were measured. Fecal Bifidobacterium counts at 4 days and 1 month were quantified using real-time polymerase chain reaction. The development of AD was determined by means of a questionnaire at 7 months of age. Results: The levels of released IL-10 were significantly lower in infants with AD (n = 17) than in infants without AD (n = 53) for all stimuli. In infants with fecal Bifidobacterium, the incidence of AD was inversely associated with the release of IL-10 from cord blood mononuclear cells. Conclusion: Our findings suggest that impaired IL-10 production in response to microbial stimuli at birth may be associated with an increased risk of developing infantile AD, even in infants with early colonization of intestinal bifidobacteria.

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IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years

Cited by 35 publications

References 48 publications

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with <b><i>Bifidobacterium</i></b> Colonization

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