IL1 Gene Cluster Polymorphisms and Its Haplotypes may Predict the Risk to Develop Invasive Pulmonary Aspergillosis and Modulate C-reactive Protein Level

Abstract

These findings indicate a critical role of IL1 gene cluster polymorphisms in the susceptibility to IPA infection and CRP production.

Heritability ofIL-1AGene Promoter Polymorphism in Patients With Coronary Artery Disease: A Trio-Family Study

“…Variations in the minor allele frequency from healthy individuals have been reported from China at 34.6% 12 and among whites at 31.08%. 20 The minor T allele frequency in healthy subjects of our population was consistent with other reports. Our findings show a significant difference in the IL-1A-889 C/T genotype distribution between patients with CAD and healthy controls.…”

Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates

“…Additionally, single-nucleotide polymorphisms in the IL-1 gene cluster have been shown to be associated with greater risks of patients developing IA (28,29), while polymorphisms in the NLRP3 gene were associated with recurrent vulvovaginal candidiasis in a subset of women (30). The IL-1 gene cluster codes for IL-1␣, IL-1␤, as well as the IL-1 receptor antagonist (IL-1ra), all of which can bind to IL-1 receptor type I (IL-1RI) (31).…”

Host genetics of invasive Aspergillus and Candida infections

“…Cytokines, chemokines, and their receptors A series of relatively small studies associated SNPs in genes encoding cytokines and chemokines such as IL10 [62], IL1B [63], IL1A [63], Fig. 1 Candidate gene polymorphisms associated with invasive Aspergillus and/or Candida infections.…”

“…1 Candidate gene polymorphisms associated with invasive Aspergillus and/or Candida infections. ASC apoptosis-associated specklike protein containing a CARD; BCL10 B cell CLL/lymphoma 10; CARD9 caspase recruitment domain-9; CCL8 chemokine C-C motif ligand 8; CXCL10 CXC chemokine ligand-10; DC-SIGN dendritic cellspecific intercellular adhesion molecule-3-grabbing non-integrin; DEFB1 β-defensin 1; IL interleukin; IL1RN interleukin-1 receptor antagonist; IL23R interleukin 23 receptor; MASP2 mannan-binding lectin serine peptidase 2; MBL mannose-binding lectin; MYD88 myeloid differentiation primary response protein; NALP3 NACHT, LRR, and PYD domains-containing protein 3; NF-κB nuclear factor-κB; PLG plasminogen; PTX3 pentraxin 3; RAGE advanced glycosylation endproduct-specific receptor; S100B S100 calcium-binding protein B; STAT1 signal transducer and activator of transcription 1; TNFA tumor necrosis factor alpha; TNFR tumor necrosis factor receptor; TRIF TIRdomain-containing adapter-inducing interferon-β; TLR Toll-like receptor and CXCL10 [64], as well as their receptors (IL23R [65], TNFR1, and TNFR2 [66,67]) or antagonists (interleukin-1 receptor antagonist, IL1RA [63]) with susceptibility to IA. Among them, only the association with IL10 has been validated by independent researchers, yet without biological clarification (Table 2).…”