IL-8 Is an Important Contributor to Both the Progression of Systematic Inflammation and Increasing Severity of Non-Alcoholic Fatty Liver Disease (NAFLD)

Birerdinc, Aybike; Keaton, Maria; Doyle, Katherine; Younoszai, Zahra; Wang, Lei; Goodman, Zachary; Baranova, Ancha; Younossi, Zobair

doi:10.14309/00000434-201410002-00575

Cited by 1 publication

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“…Birerdinc et al [ 57 ], in a cohort of 241 morbidly obese patients, showed that IL-8 positively correlates with several cytokines (e.g., IL-10, IL-12, IL-13, IL-17, and TNF-α). Liver damage indicators (e.g., such as ballooning, bridging, infiltrating Kupffer cells, polymorphonuclear neutrophils, pericellular fibrosis, portal fibrosis, and portal inflammation) showed positive correlations with IL-8, suggesting that IL-8 plays a crucial role in systemic inflammation progression and, more importantly, contributes significantly to the escalating severity of liver disease in NAFLD [ 57 ].…”

Section: Pathophysiological Aspects Of Interleukins In Nafldmentioning

confidence: 99%

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Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease

Rafaqat,

Gluscevic,

Mercantepe

et al. 2024

Metabolites

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Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.

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Section: Pathophysiological Aspects Of Interleukins In Nafldmentioning

confidence: 99%

“…IL-8 plays a crucial role in systemic inflammation progression and, more importantly, contributes significantly to the escalating severity of liver disease in NAFLD [57].…”

mentioning

confidence: 99%