IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

Španko, Michal; Strnadová, Karolína; Pavlíček, A.; Szabó, Pavol; Kodet, Ondřej; Valach, Jaroslav; Dvořánková, Barbora; Smetana, Karel; Lacina, Lukáš

doi:10.3390/ijms222011027

Cited by 18 publications

(20 citation statements)

References 222 publications

(251 reference statements)

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“…CAFs produce numerous bioactive factors, which have been reviewed extensively in numerous articles [10,[108][109][110][111][112]. When comparing different tumour types, IL-6 seems to be widely expressed by CAFs in many, if not in virtually all, cancer types [51,113].…”

Section: Production Of Bioactive Factors With Emphasis On Il-6mentioning

confidence: 99%

“…Nevertheless, current cancer therapy is frequently based on combinations, and the simultaneous targeting of several mechanisms can be beneficial and affordable. Therefore, the targeting of IL-6 along with the targeting of other molecules seems to be worthy of attention [111,113,120]. We can hypothesise as to which factors should be hit along with IL-6.…”

Section: Production Of Bioactive Factors With Emphasis On Il-6mentioning

confidence: 99%

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Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Vokurka

Lacina

Brábek

et al. 2022

IJMS

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Cancer-associated fibroblasts (CAFs) are an essential component of the tumour microenvironment. They represent a heterogeneous group of cells that are under the control of cancer cells and can reversely influence the cancer cell population. They affect the cancer cell differentiation status, and the migration and formation of metastases. This is achieved through the production of the extracellular matrix and numerous bioactive factors. IL-6 seems to play the central role in the communication of noncancerous and cancer cells in the tumour. This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts. Available data on the exosomal cargo, which can significantly intensify interactions in the tumour, are summarised. The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance. The functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.

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Section: Production Of Bioactive Factors With Emphasis On Il-6mentioning

confidence: 99%

Section: Production Of Bioactive Factors With Emphasis On Il-6mentioning

confidence: 99%

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Vokurka

Lacina

Brábek

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

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“…Our previous papers deal in detail with the mechanisms and cellular sources of the pleiotropic cytokine IL-6 (Lacina et al 2019(Lacina et al , 2021Brábek et al 2020;Čoma et al 2021;Španko et al 2021). Almost all cells in the human body can produce IL-6.…”

Section: Role Of Il-6 and Other Inflammation-supporting Factorsmentioning

confidence: 99%

“…Targeting the IL-6 signalling represents a plausible therapeutic strategy for several autoimmune diseases and cancers (Brábek et al 2020;Španko et al 2021) (Fig. 5).…”

Section: The Therapeutic Consequences Of Covid-19mentioning

confidence: 99%

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

Gál

Brábek

Holub

et al. 2022

Histochem Cell Biol

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Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19.

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“…Some biomarkers, for example, IL-6, could be used in oral health screening, especially for early stage oral precancer lesions [ 14 ]. Pro-inflammatory cytokine (IL-1, IL-6, IL-8 and TNF- Alpha) and anti-inflammatory cytokine (IL-4, IL-10 and IL-13) levels are higher in individuals with oral cancer [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Correlation of Swedish Snus, Nicotine Pouches and Other Tobacco Products with Oral Mucosal Health and Salivary Biomarkers

et al. 2022

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In society, tobacco products, such as e-cigarettes, and smokeless tobacco products, such as snus and nicotine pouches, are becoming more attractive. There is still a lack of information regarding the effects of these products on the oral mucosa and oral saliva biomarkers. The aim of this study is to evaluate oral mucosa and the presence of inflammatory biomarkers IL-6, IL-1, IL-8, TNF alpha and LRG-1 in saliva. Respondents were divided in four groups based on their tobacco product usage. Oral examination was carried out, saliva samples were taken, and the detection of IL-6, IL-8, IL-1, TNF alpha and LRG-1 levels in saliva was carried out. Out of the tobacco users, 30.8% were snus users, 48.7% were cigarette users and 20.5% were e-cigarette users. The control group was composed of respondents who did not use any tobacco products. E-cigarettes were used more by women, but snus was used more by men. Mucosal changes were seen in the group of snus users, and mucosal changes were only seen in men who had used 5–10 tobacco units per day for 5–10 years. Increased IL-6 levels in saliva were detected in respondents who also experienced mucosal changes. Mucosal changes were white, leathery and localized at the site where snus sachets were placed. Saliva, as an easily available biofluid, could be used as a first tool to detect potentially precancerous signs, but the LRG1 marker cannot be used as a prognostic marker.

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IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

Cited by 18 publications

References 222 publications

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production

Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

The Correlation of Swedish Snus, Nicotine Pouches and Other Tobacco Products with Oral Mucosal Health and Salivary Biomarkers

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