IL-6 and its role in IgA nephropathy development

Groza, Yaroslava; Jemelkova, Jana; Kafková, Leona Rašková; Malý, Petr; Raška, Milan

doi:10.1016/j.cytogfr.2022.04.001

Cited by 22 publications

(9 citation statements)

References 134 publications

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“…IL‐6‐activated pathways are involved in B‐cell, plasma cell, and Th17 cell activation and differentiation 6 . Dysfunctional IL‐6 production or enhanced receptor responses to IL‐6 signaling are associated with several autoimmune diseases, including IgA nephropathy (IgAN), where increased plasma concentrations of IL‐6 are directly associated with increased plasma concentration of aberrantly galactosylated IgA and disease activity 7 . In our patient we noted that tocilizumab also decreased serum IgA levels (666 mg/dL–>434 mg/dL).…”

Section: Discussionmentioning

confidence: 99%

Linear IgA bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with Anti‐IL‐6 receptor monoclonals

Jordan

Balzer

Nast

et al. 2023

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Linear IgA bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with Anti‐IL‐6 receptor monoclonals

Jordan

Balzer

Nast

et al. 2023

Clinical Case Reports

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“…We found that B cells present in the submucosal lymphoid tissue mainly express IL-6 mRNA in the epipharyngeal mucosa of patients with chronic epipharyngitis ( Figure 2 ). IL6 secretion from B cells correlates with the severity of humoral autoimmune disease [ 30 ], and IL6 is involved in the pathogenesis of IgAN by promoting IgA production [ 17 , 31 ]. In addition, sustained IL-6 activity also affects the development of ME/CFS and neuropsychiatric symptoms of Long COVID [ 14 , 18 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory cytokine IL-6 is highly expressed in various chronic inflammatory diseases and is a therapeutic target in inflammatory diseases [ 12 , 13 ]. In fact, the high expression level of IL-6 in serum or plasma has been reported to be involved in the development of IgA nephropathy, ME/CFS, and Long COVID [ 14 , 15 , 16 , 17 , 18 ]. The purpose of this study was to clarify the mechanism of effectiveness for systemic diseases of EAT by analyzing the expression pattern of IL-6 in the epipharyngeal mucosa of patients with chronic epipharyngitis before and after EAT.…”

Section: Introductionmentioning

confidence: 99%

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis

Nishi

Yoshimoto

Nishi

et al. 2022

IJMS

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The epipharynx, located behind the nasal cavity, is responsible for upper respiratory tract immunity; however, it is also the site of frequent acute and chronic inflammation. Previous reports have suggested that chronic epipharyngitis is involved not only in local symptoms such as cough and postnasal drip, but also in systemic inflammatory diseases such as IgA nephropathy and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID. Epipharyngeal Abrasive Therapy (EAT), which is an effective treatment for chronic epipharyngitis in Japan, is reported to be effective for these intractable diseases. The sedation of chronic epipharyngitis by EAT induces suppression of the inflammatory cytokines and improves systemic symptoms, which is considered to be one of the mechanisms, but there is no report that has proved this hypothesis. The purpose of this study was to clarify the anti-inflammatory effect of EAT histologically. The study subjects were 8 patients who were not treated with EAT and 11 patients who were treated with EAT for chronic epipharyngitis for 1 month or more. For immunohistochemical assessment, the expression pattern of IL-6 mRNA, which plays a central role in the human cytokine network, was analyzed using in situ hybridization. The expression of IL-6 in the EAT-treated group was significantly lower than those in the EAT nontreated group (p = 0.0015). In addition, EAT suppressed the expression of tumor necrosis factor alpha (TNFα), a crucial proinflammatory cytokine. As a result, continuous EAT suppressed submucosal cell aggregation and reduced inflammatory cytokines. Thus, EAT may contribute to the improvement of systemic inflammatory diseases through the suppression of IL-6 expression.

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“…A variety of cytokines participate in the coordination of the immune system and respond to endogenous or exogenous stimuli ( 34 – 36 ). Previous studies have showed that CP derived from enzymatic hydrolysate of Salmo salar skin had anti-inflammatory effects in LPS-induced Raw264.7 cell model ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

Cui²,

Feng³

et al. 2022

Front. Nutr.

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Ulcerative colitis (UC) is an inflammatory bowel disease caused by mucosal immune system disorder, which has increased steadily all over the world. Previous studies have shown that collagen peptide (CP) has various beneficial biological activities, it is not clear whether the effect of CP on UC is positive or negative. In this study, 2.5% dextran sulfate sodium (DSS) was used to establish acute colitis in mice. Our results suggested that CP supplementation (200, 400 mg/kg/day) promoted the progression of colitis, increased the expression of inflammatory factors and the infiltration of colonic lamina propria macrophages. Gut microbiota analysis showed the composition changed significantly and inflammation promoted bacteria was after CP treatment. Meanwhile, the effect of CP on macrophage polarization was further determined in Raw264.7 cell line. The results showed that CP treatment could increase the polarization of M1 macrophages and promote the expression of inflammatory factors. In conclusion, our results showed that CP treatment could disrupt the gut microbiota of host, promote macrophage activation and aggravate DSS-induced colitis. This may suggest that patients with intestinal inflammation should not take marine derived CP.

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IL-6 and its role in IgA nephropathy development

Cited by 22 publications

References 134 publications

Linear IgA bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with Anti‐IL‐6 receptor monoclonals

Linear IgA bullous dermatosis and elevated bullous interleukin‐6 levels: Responsive to treatment with Anti‐IL‐6 receptor monoclonals

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

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