IL-6-6331 (T/C, rs10499563) is Associated with Decreased Risk of Gastric Cancer in Northern Chinese

Li, Yang; Sun, Mingjun; Liu, Jingwei; Xu, Qian; Yuan, Yuan

doi:10.7314/apjcp.2013.14.12.7467

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…Interestingly, this finding could not be associated with Helicobacter pylori infection, implying that other cellular mechanisms could contribute to the increased susceptibility of A allele carriers for the development of intestinal type of GC. In another study, it has been shown that the TC or CC genotypes of IL‐6 rs10499563 were associated with a reduced risk of diffuse type GC [Yang et al, ]. In a study evaluating HMGB1 rs1045411, it was observed that AG/AA genotypes conferred more favorable prognosis.…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility

Mesic

Markocic

Rogar

et al. 2017

Environ and Mol Mutagen

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Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility

Mesic

Markocic

Rogar

et al. 2017

Environ and Mol Mutagen

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“…Although genetic and environmental factors in addition to Helicobacter pylori infections have been identified to play important roles in the development of gastric cancer (Houghton and Wang, 2005;Merchant, 2005;Dong et al, 2008), the precise etiology of the disease remains unclear. Notably, more and more studies have indicated that genetic variants of interleukin (IL) family genes may be involved in the development of gastric cancer (El-Omar et al, 2000;Xue et al, 2012;Yang et al, 2013;Pan et al, 2014;Zhu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Sun

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have indicated that single nucleotide polymorphisms (SNPs) of the interleukin-17 (IL-17) gene are associated with an increased risk of gastric cancer. However, the findings were inconsistent. Materials and Methods: To provide a more reliable estimation of the association between SNPs in the IL-17 gene and the susceptibility to gastric cancer, we searched PubMed, CNKI, and Wan Fang databases and selected finally six studies covering 2,366 cases and 3,205 controls to perform a meta-analysis. Results: Statistical analyses showed that an rs2275913 polymorphism within the IL-17A gene was significantly associated with an increased risk of gastric cancer using a generalized odds ratio (ORG, a model-free approach). Moreover, we also found that the 'A' allele carriers of IL-17A rs2275913 had a significant link with clinicopathological features. However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively. Conclusions: Despite some limitations, the present meta-analysis provided a more precise estimation of the relationship between the IL-17 gene SNPs and gastric cancer risk compared with individual studies.

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“…It was stated that IL-6 rs10499563 was a functional polymorphism site in the promoter region of IL-6 and could transcriptionally regulate the expression of IL-6 [15]. Recently, several researchers found that IL-6 rs10499563 polymorphism was linked to gastric cancer risk [16,17]. However, the relationship of IL-6 rs10499563 and the progression of HBVrelated liver cirrhosis has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis

Xia

Zhu

Huang

et al. 2019

Preprint

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Background Interleukin-6 (IL-6) plays an important role in chronic inflammation. Thus, we aimed to investigate the effects of IL-6 polymorphisms in predicting the progression of hepatitis B virus (HBV) -related liver cirrhosis. Methods A cross-sectional study was conducted to analysis IL-6 polymorphisms and serum levels of IL-6 in HBV-infected patients of different clinical phases and in healthy controls. IL-6 polymorphisms were detected by Taqman PCR method and plasma IL-6 levels were assessed by ELISA. Results Our analysis included 182 chronic hepatitis B (CHB) patients, 190 HBV-infected liver cirrhosis cases, 125 inactive HBsAg carriers, and 246 healthy controls. Seven SNPs in IL-6 including rs10499563, rs17147230, rs1800796, rs2069837, rs1524107, rs2066992, rs2069852 were analyzed. In haplotype analysis between HBV-infected liver cirrhosis cases with CHB patients, inactive HBV-carriers or healthy controls, haplotype CT in block 1 and haplotype GGCGG in block 2 were associated with liver cirrhosis (P<0.05). What’s more, the genotype or allele frequencies were significantly different in IL-6 rs10499563 and rs2069837 when HBV-infected liver cirrhosis patients compared with CHB patients, inactive HBV-carriers or healthy controls. A further study found that compared with the controls or CHB patients, plasma IL-6 was elevated in HBV-infected liver cirrhosis patients (P<0.05). Conclusion In conclusion, the polymorphisms of the IL-6 rs10499563 and rs2069837 are associated with the susceptibility of liver cirrhosis may through their effects on IL-6 expressions and these two single nucleotide polymorphisms can be used as potential predicting markers for prognosis of HBV-infected liver cirrhosis.

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IL-6-6331 (T/C, rs10499563) is Associated with Decreased Risk of Gastric Cancer in Northern Chinese

Abstract: Background: Polymorphisms of genes encoding cytokines could be potential biomarkers to predict risk of gastric cancer (GC). Here, we investigated the association between the IL-6 -6331 (T/C, rs10499563) polymorphism in its promoter region and GC risk.

Cited by 14 publications

References 22 publications

Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility

Single nucleotide polymorphisms rs911160 in AURKA and rs2289590 in AURKB mitotic checkpoint genes contribute to gastric cancer susceptibility

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis

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