IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity

Phu, Tuan Anh; Ng, M.; Vu, Ngan K; Bouchareychas, Laura; Raffaı̈, Robert L.

doi:10.1016/j.ymthe.2022.03.008

Cited by 39 publications

(34 citation statements)

References 68 publications

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“…Intercellular communication through either cell‐to‐cell contact or paracrine effects is believed to be a key process in vascular remodeling 34,35 . Exosomes, which are newly identified natural nanocarriers and intercellular messengers, play a pivotal role in regulating cell‐to‐cell communication and have emerged as important mediators in the pathogenesis of vascular diseases, including atherosclerosis, neointima formation (and vascular repair), primary hypertension, pulmonary artery hypertension, and aortic aneurysm 33,36–39 . Exosomes show excellent prognostic and therapeutic potential for vascular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…34,35 Exosomes, which are newly identified natural aneurysm. 33,[36][37][38][39] Exosomes show excellent prognostic and therapeutic potential for vascular diseases. Our study suggests that in addition to somatic KRAS mutations, EC-EC communication also contributes to the pathogenesis and development of bAVMs.…”

Section: Discussionmentioning

confidence: 99%

“… 34 , 35 Exosomes, which are newly identified natural nanocarriers and intercellular messengers, play a pivotal role in regulating cell‐to‐cell communication and have emerged as important mediators in the pathogenesis of vascular diseases, including atherosclerosis, neointima formation (and vascular repair), primary hypertension, pulmonary artery hypertension, and aortic aneurysm. 33 , 36 , 37 , 38 , 39 Exosomes show excellent prognostic and therapeutic potential for vascular diseases. Our study suggests that in addition to somatic KRAS mutations, EC–EC communication also contributes to the pathogenesis and development of bAVMs.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Exosomal miR‐3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations

Huo

Wang

et al. 2023

CNS Neurosci Ther

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exosomal miR‐3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations

Huo

Wang

et al. 2023

CNS Neurosci Ther

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show abstract

“…Another study by the same team demonstrated that BMDM-exos contain the anti-inflammatory microRNA 99a/146b/378a, which inhibits inflammation by targeting the NF-κB and TNF-α signaling pathways, providing a new direction for anti-inflammatory therapy for atherosclerosis 101 . THP1-IL-4-exo regulates energy metabolism by regulating microRNA levels, and in vivo injection of THP1-IL-4-exo into two different mice with lipid metabolism disorders has been shown to reduce hemopoiesis and myelopoiesis 113 .…”

Section: Macrophage-associated Exosomes In Arteriosclerosismentioning

confidence: 99%

Exosomes in atherosclerosis: Convergence on macrophages

Yang¹,

Xiao²,

Niu³

et al. 2022

Int. J. Biol. Sci.

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As the primary cells of atherosclerotic plaques, macrophages play a central role in the occurrence and progression of atherosclerosis (AS). In recent years, macrophages have received extensive attention as therapeutic targets. Exosomes, as natural nanoparticles, have high biocompatibility and strong targeting ability and have been widely studied as imaging agents and drug carriers. Studies on the relationship between atherosclerotic macrophages and exosomes have been focused on for the past few years. Nevertheless, no complex review has been undertaken in this area. In this review, we summarize in detail the role of macrophages in atherosclerosis, especially their plasticity and phenotypic and distributional heterogeneity. Based on the high correlation between macrophages and the pathological process of atherosclerosis, as well as the targeting of exosomes, we further review the clinical application of targeting macrophage-associated exosomes. We focus on the role of macrophage-associated exosomes in the phenotypic transformation of cells in atherosclerosis, providing a new idea for the clinical application of targeting macrophage-associated exosomes. Finally, we specifically summarize and prospect the diagnosis of macrophage-associated exosomes, such as imaging agent delivery, biomarkers and therapeutic strategies.

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“…Exosomes from different sources can produce effects against different diseases. For example, macrophages produce exosomes that contribute to cellular signaling in many pathologies, especially in cardiovascular diseases ( Phu et al, 2022 ).…”

Section: Production Process Of Exosomesmentioning

confidence: 99%

The status of industrialization and development of exosomes as a drug delivery system: A review

Yin

Han

et al. 2022

Front. Pharmacol.

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Exosomes, as natural biomolecular carriers produced by cells, have the potential and advantage of delivering drugs to target organs or cells in vivo. The steps to improve exosomes as a drug delivery system can be divided into three steps:large-scale preparation of exosomes, loading of drugs and targeted delivery of exosomes. Based on the existing production process and technology, there is still much room for improvement. This review highlights the research progress in three aspects and proposes new technologies and innovative approaches to improve the efficiency of exosome delivery.

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IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity

Cited by 39 publications

References 68 publications

Exosomal miR‐3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations

Exosomal miR‐3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations

Exosomes in atherosclerosis: Convergence on macrophages

The status of industrialization and development of exosomes as a drug delivery system: A review

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